Quantifying the Trainability of Peripheral Nerve Function in Young and Older Adults.

NCT06614556 | Completed

• 1 other identifier: IRB-22-270
• Study Type: interventional
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this project is to identify the effects of hand grip resistance training on nerve speed of the hand muscles and to quantify whether age plays a role in those effects. Two groups (young and older adults) underwent a 4-week resistance training intervention with nerve conduction velocity measured before and after. There were also two control groups (young and older adults) who performed the testing 4 weeks apart, but did not engage in the intervention.

Conditions

Nerve Degeneration; Healthy Aging

Outcome Measures

Primary Outcomes (1)

• Motor nerve conduction velocity (m/s)

  Conduction velocity of the median nerve, via nerve stimulation, as measured through EMG at the Flexor Digitorum Superficialis muscle

  Before and after 4 weeks of training (or just 4 weeks, for controls)

Secondary Outcomes (3)

• Nerve cross-sectional area (mm^2)

  Before and after 4 weeks of training (or just 4 weeks, for controls)

• Maximal strength (kg)

  Before and after 4 weeks of training (or just 4 weeks, for controls)

• Hand motor dexterity (seconds)

  Before and after 4 weeks of training (or just 4 weeks, for controls)

Study Arms (4)

Young Training Group

EXPERIMENTAL

Ages 18-35. Performed 4 weeks of an at-home, hand grip resistance training intervention.

Other: Resistance Training

Young Control Group

NO INTERVENTION

Ages 18-35. Did not perform the training intervention

Older Training Group

EXPERIMENTAL

Ages 60+. Performed 4 weeks of an at-home, hand grip resistance training intervention.

Other: Resistance Training

Older Control Group

NO INTERVENTION

Ages 60+. Did not perform the training intervention

Interventions

Resistance Training OTHER

Participants in the training groups performed bilateral hand grip resistance training three times per week for four weeks using a specialized hand-grip kit provided to them. Participants were provided with pictures and instructions for each exercise upon completion of the initial testing (PRE) session. They were asked to perform 12 training sessions (approximately 30-45 mins) over the 4 weeks according to their schedule. Each participant was asked to keep a training log to assist with accountability. Those assigned to the control groups were asked to maintain their normal daily activities throughout the four weeks.

Also known as: Strength Training, Exercise

Older Training Group; Young Training Group

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Apparently healthy adults 18 - 100 years old.

You may not qualify if:

• If you have been notified by a physician to refrain from exercise due to cardiovascular issues.
• Known orthopedic or neuromuscular limitations or illness of the upper extremities.
• Known neuromuscular disorders.
• Individuals that are experiencing a fever (\> 100.4° F) or have identified as symptomatic on the COVID-19 screening questionnaire may not participate at this time.

Sponsors & Collaborators

• Oklahoma State University: lead
• American College of Sports Medicine - Central States Chapter: collaborator

Study Sites (1)

Applied Neuromuscular Physiology Laboratory

Stillwater, Oklahoma, 74078, United States

Location

MeSH Terms

Conditions

Nerve Degeneration

Interventions

Resistance Training; Exercise

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Jason M DeFreitas, PhD

  Oklahoma State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2024
• First Posted: September 26, 2024
• Study Start: September 20, 2022
• Primary Completion: July 18, 2023
• Study Completion: July 18, 2023
• Last Updated: September 26, 2024

Record last verified: 2024-09

Locations

US (1)