Resistance Training and Sex Hormone Concentrations During the Menstrual Cycle

NCT04163380 | Unknown

• 1 other identifier: 111B
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Although there are numerous studies showing effects of aerobic training on sex hormone concentrations, research analyzing the fluctuation of sex hormones in response to resistance training (RT) is lacking. The objective of this project is to analyze estradiol (E2) and progesterone (P4) responses to an acute resistance training session throughout different phases of the menstrual cycle. This proposed research has strong implications for exercise prescription and for women in general, but more importantly will allow exercise physiologists, coaches, personal trainers, or nutritionists optimize exercise programming around women's menstrual cycle.

Conditions

Women's Health

Keywords

Estrogen; Progesterone; Menstrual Cycle; Resistance Training

Outcome Measures

Primary Outcomes (2)

• Change in estrogen concentrations

  Estrogen concentrations will be obtained from blood samples assessed using through ELISA kits

  through study completion, an average of 5 weeks

• Change in progesterone concentrations

  Progesterone concentrations will be obtained from blood samples assessed using through ELISA kits

  through study completion, an average of 5 weeks

Secondary Outcomes (8)

• Lean body mass (kg)

  At baseline: 1 assessment point

• Fat mass (kg)

  At baseline: 1 assessment point

• Relative body fat (%)

  At baseline: 1 assessment point

• Skeletal muscle mass (kg)

  At baseline: 1 assessment point

• Cardiorespiratory Fitness

  At baseline: 1 assessment point

Study Arms (4)

Early Follicular Phase (EFP)

EXPERIMENTAL

Behavioral: Resistance Training

Late Follicular Phase (LFP)

EXPERIMENTAL

Behavioral: Resistance Training

Early Luteal Phase (ELP)

EXPERIMENTAL

Behavioral: Resistance Training

Late Luteal Phase (LLP)

EXPERIMENTAL

Behavioral: Resistance Training

Interventions

Resistance Training BEHAVIORAL

Participants will exercise at the mid-point of each menstrual cycle phase (EFP- day 4, LFP- day 11, ELP- day 18 and LLP- day 25 for a 28 day menstrual cycle). Training will consist of a warm up. Intensity will be set at 70% of 1RM, and the circuit training will include 7 strength exercises: leg press, rows, back squat, weighted crunches, deadlifts, bench press, and weighted squat jumps. The participant will perform 3 sets f 10 repetitions with 30 seconds of rest

Early Follicular Phase (EFP); Early Luteal Phase (ELP); Late Follicular Phase (LFP); Late Luteal Phase (LLP)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Gender Eligibility Details: Females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Eumenorrheic females
• Age 18-45 years old
• BMI of 18.5-34.99 kg/m2

You may not qualify if:

• Practice exercise more than 2 days/week in the last 3 months.
• Cardiovascular, metabolic, pulmonary or muscular-skeletal condition
• Taking medications that affect metabolism (e.g. oral contraceptives)
• Irregular menstrual cycles

Sponsors & Collaborators

• Southern Illinois University Edwardsville: lead

Study Sites (1)

Southern Illinois University Edwardsville

Edwardsville, Illinois, 62026, United States

RECRUITING

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Maria Fernandez del Valle, PhD

CONTACT

6186505905; marfern@siue.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will be blocked (four participants by block) and then randomized to start in one of the four menstrual cycle phases (EFP, LFP, ELP, or LLP). Their will be complete once they have gone through the four phases.

Study Record Dates

• First Submitted: October 30, 2019
• First Posted: November 14, 2019
• Study Start: November 1, 2019
• Primary Completion: December 1, 2021
• Study Completion: December 1, 2021
• Last Updated: February 18, 2020

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)