Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

NCT05017896 | Unknown

• 1 other identifier: 2020SDUCRCC031
• Study Type: observational
• Target: 242
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Conditions

Aneurysm, Dissecting; Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• Acute kidney injury after operation

  Yes; No

  From date of operation until the date of acute kidney injury or date of death from any cause, whichever came first, assessed up to 30 days.

Study Arms (2)

Normal Perfusion

Diagnostic Test: Normal CT Renal Perfusion imaging indexes

Low Perfusion

Diagnostic Test: Low CT Renal Perfusion imaging indexes

Interventions

Normal CT Renal Perfusion imaging indexes DIAGNOSTIC_TEST

A CT imaging which indicates the status of renal perfusion is normal.

Normal Perfusion

Low CT Renal Perfusion imaging indexes DIAGNOSTIC_TEST

A CT imaging which indicates the status of renal perfusion is low.

Low Perfusion

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients sufferred acute type A aortic dissection.

You may qualify if:

• years old
• Acute type A aortic dissection diagnosed by CT angiography
• Sign informed consent

You may not qualify if:

• History of chronic kidney disease
• History of cardiovascular operation
• Acute kidney injury has occurred before operation
• Pregnancy status

Sponsors & Collaborators

• Qilu Hospital of Shandong University: lead

MeSH Terms

Conditions

Aortic Dissection; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Dissection, Blood Vessel; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Acute Aortic Syndrome; Aortic Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Xin Zhao

  Department of cardiac surgery, Qilu Hospital, Shandong University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Xin Zhao

CONTACT

+8618560086772; zhaoxin3617@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 17, 2021
• First Posted: August 24, 2021
• Study Start: September 1, 2021
• Primary Completion: January 1, 2023
• Study Completion: February 1, 2023
• Last Updated: August 24, 2021

Record last verified: 2021-08