Renal Doppler Ultrasound in Early Detection of Acute Kidney Injury in Critically Ill Patients

NCT03902483 | Unknown DMC

• 1 other identifier: MSA
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acute kidney injury is a common complication of critical illness and is associated with high morbidity and mortality .Acute kidney injury is a syndrome that is characterized by a rapid decline in renal function and urine output, resulting in retention of waste products such as urea, nitrogen, and serum creatinine. Life-threatening consequences include volume overload, hyperkalaemia, and metabolic acidosis . In its severe form, Acute kidney injury requires renal replacement therapy, which is applied in 5±13% of Intensive Care Unit patients

Conditions

Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• Role of Doppler Renal resistative index in early Prediction of acute kidney injury in critically ill patients

  Renal resistive index was measured with ultrasound-Doppler using atransparietal 5MHz pulsed-wave Doppler probe. After visualizing the kidney in ultrasound mode and checking for renal abnormalities, an arcuate or interlobar artery will be localized and three successive Doppler measurements at different positions in the kidney (high, middle and low) will be performed, 3 times in each kidney. So a total number of 9 RRI values will be obtained in each kidney.The median value of each section will be used and the 3 median values of each kidney will be averaged. patients developing AKI would have an AKI of 0.79 with a standard deviation of 0.11

  at one day of the study

Interventions

renal doppler ultrasound DEVICE

renal doppler ultrasound measuring renal resistive index

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

80 patients of critically ill patients including acute ischaemic insults, patients presenting with septicaemia, hypertension, respiratory failure, coagulation/ haemorrhagic disorders, shock, and liver diseasea and shock. This study will be performed in the 24-bed mixed medical and surgical intensive care unit of the Assiut University Hospital. Sample size calculations will be based on the assumption that patients not developing Acute Kidney Injury would have an RRI of 0.72 and patients developing Acute Kidney Injury would have an Acute Kidney Injury of 0.79 with a standard deviation of 0.11. These calculations were based on the results of other previous studies that reported median values for Acute Kidney Injury and no Acute Kidney Injury

You may qualify if:

• age \>18 years ICU admission within 24 hours

You may not qualify if:

• Poor abdominal echogenicity
• Severe acute or chronic renal insufficiency
• Dialysis dependency, renal transplantation
• Renal artery stenosis, congenital renal diseases ,renal tumor
• Suicidal attempt
• Pregnancy

Sponsors & Collaborators

• Assiut University: lead

Related Publications (7)

• Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet. 2012 Aug 25;380(9843):756-66. doi: 10.1016/S0140-6736(11)61454-2. Epub 2012 May 21.

  PMID: 22617274 BACKGROUND

• Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honore PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Vidal Andrade E, Webb S, Kellum JA. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015 Aug;41(8):1411-23. doi: 10.1007/s00134-015-3934-7. Epub 2015 Jul 11.

  PMID: 26162677 BACKGROUND

• Hilton R. Acute renal failure. BMJ. 2006 Oct 14;333(7572):786-90. doi: 10.1136/bmj.38975.657639.AE. No abstract available.

  PMID: 17038736 BACKGROUND

• Basile DP, Anderson MD, Sutton TA. Pathophysiology of acute kidney injury. Compr Physiol. 2012 Apr;2(2):1303-53. doi: 10.1002/cphy.c110041.

  PMID: 23798302 BACKGROUND

• Gomez H, Ince C, De Backer D, Pickkers P, Payen D, Hotchkiss J, Kellum JA. A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock. 2014 Jan;41(1):3-11. doi: 10.1097/SHK.0000000000000052.

  PMID: 24346647 BACKGROUND

• Spatola L, Andrulli S. Doppler ultrasound in kidney diseases: a key parameter in clinical long-term follow-up. J Ultrasound. 2016 Apr 16;19(4):243-250. doi: 10.1007/s40477-016-0201-x. eCollection 2016 Dec.

  PMID: 27965714 BACKGROUND

• Leoncini G, Martinoli C, Viazzi F, Ravera M, Parodi D, Ratto E, Vettoretti S, Tomolillo C, Derchi LE, Deferrari G, Pontremoli R. Changes in renal resistive index and urinary albumin excretion in hypertensive patients under long-term treatment with lisinopril or nifedipine GITS. Nephron. 2002 Feb;90(2):169-73. doi: 10.1159/000049038.

  PMID: 11818701 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• abdalla ismael

  Dr.

  STUDY DIRECTOR

Central Study Contacts

manar salah, resident

CONTACT

01092058750; manarsalah290@yahoo.com

marwa kamal, lecturer

CONTACT

01097878113; Marwa.kamal82@hotmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assiut University

Study Record Dates

• First Submitted: April 2, 2019
• First Posted: April 4, 2019
• Study Start: July 1, 2019
• Primary Completion: June 30, 2020
• Study Completion: December 1, 2021
• Last Updated: April 5, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share