Different Domains of Executive Function Dual Task Walking on Brain Activation and Gait Performance in Healthy Adults

NCT04905186 | Completed

• 1 other identifier: 202103125RINC
• Study Type: observational
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the effects of different domains of executive function (EF) during dual task walking condition on brain activation and gait performance in healthy adults. There are two experiments will be conducted in this study. Experiment 1 is a pilot study to determine the same level of difficulty in 3 EF domains, including inhibition, working memory and cognitive flexibility. Experiment 2 is carried out to investigate the effects of 3 different domains of EF which difficulties are controlled on gait performance and brain activation in dual task condition. 10 subjects will perform Stroop test (2s/3s/4s to change question), backward digit spans (3/4/5 digits) and naming test in Experiment 1. In Experiment 1, the primary outcome is the correct response speed (CRS) while secondary outcome will be the brain activity. In Experiment 2, 30 subjects will perform the single cognitive task A (SCTA, Stroop test), single cognitive task B (SCTB, backward digit spans), single cognitive task C (SCTC, naming test), single walking task (SWT), dual task A (DTA, walking while performing cognitive task A), dual task B (DTB, walking while performing cognitive task B) and dual task C (DTC, walking while performing cognitive task C). The CRS, gait performance, brain activity and the dual task costs (DTC) will be recorded in the Experiment 2. Brain activities in prefrontal cortex (PFC), premotor cortex (PMC) and supplementary motor area (SMAs) will be measured by functional near-infrared spectroscopy (fNIRS) during this study. One-way ANOVA with Tukey post-hoc test will be performed to establish the effect of different type of executive task on CRS or the brain activity. The differences of gait parameters and brain activity in different condition in the Experiment 2 will be examined by one-way ANOVA with repeated measured. Furthermore, the Pearson correlation coefficient will be used to examine the correlation of brain activation and executive function performance or gait parameters.

Conditions

Executive Function; Neurosciences

Keywords

executive function; dual task walking; difficulty level; brain activity; motor performance

Outcome Measures

Primary Outcomes (8)

• Experiment 1: Executive function performance- correct response speed (CRS)

  CRS is the number of correct responses per unit time (correct responses/ second)

  Day 1

• Experiment 2: Executive function performance- correct response speed (CRS)

  CRS is the number of correct responses per unit time (correct responses/ second)

  Day 1

• Experiment 2: walking performance- gait speed

  The unit is m/s

  Day 1

• Experiment 2: walking performance- cadence

  The unit is steps/min

  Day 1

• Experiment 2: walking performance- stride length

  The unit is m

  Day 1

• Experiment 2: dual task performance- dual task costs(DTC) in mobility

  DTC in mobility = (single task gait speed - dual task gait speed) / single task gait speed x 100%

  Day 1

• Experiment 2: dual task performance- dual task costs(DTC) in executive function

  DTC in executive function = (single task correct response speed - dual task correct response speed) / single task correct response speed x 100%

  Day 1

• Experiment 2: dual task performance- combine mean of dual task costs(DTC)

  combine mean of DTC = ( DTC in mobility + DTC in executive function) / 2

  Day 1

Secondary Outcomes (7)

• Experiment 1: Brain activation over prefrontal cortex

  Day 1

• Experiment 1: Brain activities over supplementary motor area

  Day 1

• Experiment 1: Brain activities over premotor cortex

  Day 1

• Questionnaire in Chinese version

  Day 1

• Experiment 2: Brain activities over prefrontal cortex

  Day 1

Study Arms (1)

healthy adults

This is a cross-over study with no intervention.

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The population in this study are heathy adults.

You may qualify if:

• years (Experiment 1 \& 2)
• Mini-Mental State Examination (MMSE) score greater than 24 points (Experiment 1 \& 2)
• ability to walk 10 meters independently without an assistive device (Experiment 2)

You may not qualify if:

• any neurologic, orthopedic or psychological diseases (Experiment 1 \& 2)
• color vision deficiency (Experiment 1 \& 2)
• had the fall experiences within 6 months before the study (Experiment 2)

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

Location

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 13, 2021
• First Posted: May 27, 2021
• Study Start: August 1, 2021
• Primary Completion: May 23, 2022
• Study Completion: May 23, 2022
• Last Updated: June 14, 2022

Record last verified: 2022-06

Locations

TW (1)