Agility Training on Executive Function, Dual Task Performance and Brain Activation in Healthy Adults

NCT04880057 | Unknown

• 1 other identifier: 202103055RINB
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the effect of agility training on executive function, dual task walking and brain activation in healthy adults. Participants (N=70) will be randomly assigned to resistance+aerobic training group (RAeT) or agility training group (AT). Participants in RAeT (n=35) will receive 15-minute lower extremity workout first and then 25-minute moderate intensity (60-75% predicted maximal heart rate) aerobic training. Participants in AT (n=35) will do the agility exercise program consisting of technical drills, pattern running and reactive agility training. The intervention will be twelve-time group intervention (3-5persons) in four weeks, 50 minutes per session (5-minute warmup, 40- minute main training, 5-minute cool-down). Participants will undergo three measurement time points (pre-, post-intervention and one month follow-up). Outcome measures will include executive function (N-back test, stroop test and Wisconsin card sort test), single and dual task walking performance and brain activity (fNIRS on prefrontal cortex, supplementary motor area and premotor cortex). Two-way analysis of variance (ANOVA) with Tukey post-hoc test will be used to examine the group x time interaction on three outcome measures.

Conditions

Agility Training; Executive Function

Keywords

brain activity; motor performance; dual task walking; executive function; agility training

Outcome Measures

Primary Outcomes (24)

• Executive function- N-back task (3-back)

  N-back task (3-back) is used to measure working memory

  Change from Baseline score at 3 weeks

• Executive function- N-back task (3-back)

  N-back task (3-back) is used to measure working memory

  Change from Baseline score at 7 weeks

• Executive function- Stroop test

  Stroop test is used to measure the selective attention and conflict resolution.

  Change from Baseline score at 3 weeks

• Executive function- Stroop test

  Stroop test is used to measure the selective attention and conflict resolution.

  Change from Baseline score at 7 weeks

• Executive function- Wisconsin card sort test

  Wisconsin card sort test is an easy way to assess the ability of mental set shifting.

  Change from Baseline score at 3 weeks

• Executive function- Wisconsin card sort test

  Wisconsin card sort test is an easy way to assess the ability of mental set shifting.

  Change from Baseline score at 7 weeks

• Single walking performance- Walking speed

  The unit is length (cm) per seconds

  Change from Baseline cadence at 3 weeks

• Single walking performance- Walking speed

  The unit is length (cm) per seconds

  Change from Baseline cadence at 7 weeks

• Single walking performance- Cadence

  The unit is steps per minutes

  Change from Baseline cadence at 3 weeks

• Single walking performance- Cadence

  The unit is steps per minutes

  Change from Baseline cadence at 7 weeks

• Single walking performance- Stride length

  The unit is cm

  Change from Baseline cadence at 3 weeks

• Single walking performance- Stride length

  The unit is cm

  Change from Baseline cadence at 7 weeks

• Single walking performance- Step duration

  The unit is seconds

  Change from Baseline cadence at 3 weeks

• Single walking performance- Step duration

  The unit is seconds

  Change from Baseline cadence at 7 weeks

• Dual task walking performance- Walking speed

  The unit is length (cm) per seconds

  Change from Baseline cadence at 3 weeks

• Dual task walking performance- Walking speed

  The unit is length (cm) per seconds

  Change from Baseline cadence at 7 weeks

• Dual task walking performance- Cadence

  The unit is steps per minutes

  Change from Baseline cadence at 3 weeks

• Dual task walking performance- Cadence

  The unit is steps per minutes

  Change from Baseline cadence at 7 weeks

• Dual task walking performance- Stride length

  The unit is cm

  Change from Baseline cadence at 3 weeks

• Dual task walking performance- Stride length

  The unit is cm

  Change from Baseline cadence at 7 weeks

• Dual task walking performance- Step duration

  The unit is seconds

  Change from Baseline cadence at 3 weeks

• Dual task walking performance- Step duration

  The unit is seconds

  Change from Baseline cadence at 7 weeks

• Dual task walking performance- the correct rates of arithmetic task

  The participants will be instructed to subtract by 7 serially from a 3-digit number while walking at their fastest speed in dual task walking condition

  Change from Baseline cadence at 3 weeks

• Dual task walking performance- the correct rates of arithmetic task

  The participants will be instructed to subtract by 7 serially from a 3-digit number while walking at their fastest speed in dual task walking condition

  Change from Baseline cadence at 7 weeks

Secondary Outcomes (18)

• Brain activities over premotor cortex- Executive function

  Change from Baseline at 3 weeks

• Brain activities over premotor cortex- Executive function

  Change from Baseline at 7 weeks

• Brain activities over supplementary motor area- Executive function

  Change from Baseline at 3 weeks

• Brain activities over supplementary motor area- Executive function

  Change from Baseline at 7 weeks

• Brain activities over primary motor cortex- Executive function

  Change from Baseline at 3 weeks

Study Arms (2)

Resistance+Aerobic training group

ACTIVE COMPARATOR

Resistance+Aerobic training group (RAeT) RAeT includes resistance training (RT) program and aerobic training (AeT) program.

Other: Resistance+Aerobic training

Agility training group

EXPERIMENTAL

Agility training

Other: Agility training

Interventions

Resistance+Aerobic training OTHER

The RT focuses on lower extremity workout, including leg press, hamstring curls, and calf raises. The participants start with intensity at 12 RM and finished with intensity at 8 RM after 3 weeks. There are 8 repetitions, 2 sets for each action. It will take 15 minutes to complete RT. The AeT is composed by cycling on stationary bikes in the first week, stepping on steppers in 2nd week, and running on treadmills in the last week. Participants are asked to wear a portable heart rate monitor throughout the experiments. They have to maintain their heart rates in 60%-75% of predicted maximal heart rate (moderate intensity exercise), which has been shown to be benefit on cognition\[3\]. It took the participants 25 minutes to complete AeT.

Also known as: RAeT

Resistance+Aerobic training group

Agility training OTHER

AT program consists of three parts: technical drills, pattern running and reactive agility training. There will be nine sessions over 3 weeks and progress the intensity, complexity or velocity every week.

Also known as: AT

Agility training group

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• (1) age between 20 to 30 years, and (2) ability to walk 20 meters independently without an assistive device.

You may not qualify if:

• (1) overweight (BMI\>24), (2) any smoker or alcohol abusers, (3) suffering from chronic diseases that loss of control, (4) Unstable physiological conditions, such as abnormal signs like high blood pressure, headache, dyspnea, fever, etc., (5) any neuromuscular or cardiopulmonary diseases that would influent the exercise performance, and (6) suffering from diseases which exercises are their contraindications

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Central Study Contacts

Yanci Liu, Ph.D

CONTACT

0233668135; yanciliu@ntu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 3, 2021
• First Posted: May 10, 2021
• Study Start: August 2, 2021
• Primary Completion: December 31, 2022
• Study Completion: March 31, 2023
• Last Updated: June 13, 2022

Record last verified: 2022-06

Locations

TW (1)