Blood Flow Restriction During High-intensity Interval Exercise

NCT04854356 | Unknown DMC

• 1 other identifier: USM/JEPeM/20060331
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

The study is a randomized controlled trial aimed to compare the effects of blood flow restriction (BFR) in different phases (i.e., exercise versus interval) during high-intensity interval exercise (HIIE) on aerobic capacity, anaerobic capacity, isokinetic knee strength, lower limb biomechanics during single-leg landing and cycling economy among healthy adult males. Participants were randomized to three groups. Intervention was conducted for 12 weeks with 2 sessions per week. During intervention, all groups conducted HIEE on cycle ergometer with or without BFR. Assessments were conducted before the intervention, on the 6th week of intervention and after the intervention. Assessments included physical characteristics, aerobic and anaerobic capacity, lower limb biomechanics during single-leg landing and isokinetic knee strength.

Conditions

Exercise Physiology; Biomechanics

Outcome Measures

Primary Outcomes (4)

• Change of aerobic capacity from baseline to post-intervention

  Maximum oxygen consumption was measured during Astrand protocol

  12 weeks

• Change of anaerobic capacity from baseline to post-intervention

  Maximum power was measured during Wingate test protocol

  12 weeks

• Change of muscular strength from baseline to post-intervention

  The strength of the thigh muscle groups was measured using isokinetic device

  12 weeks

• Change of knee joint moments from baseline to post-intervention

  Biomechanical data measured during single-leg landing test

  12 weeks

Study Arms (3)

HIE with BFR during exercise phase

EXPERIMENTAL

BFR with 40% Arterial occlusive pressure cycling at 85% VO2max for 3 minutes and rest interval for 3 minutes (4 sets) each time during exercise

Other: Exercise with blood flow restriction (BFR)

HIE with BFR during interval phase

ACTIVE COMPARATOR

BFR with 40% Arterial occlusive pressure cycling at 85% VO2max for 3 minutes and rest interval for 3 minutes (4 sets) each during the interval

Other: Exercise with blood flow restriction (BFR)

HIE without BFR

NO INTERVENTION

Cycling at 85% VO2max for 3 minutes and rest interval for 3 minutes (4 sets) each time during exercise

Interventions

Exercise with blood flow restriction (BFR) OTHER

All participants completed high-intensity interval exercise plus (1) BFR applied during exercise phase, or (2) BFR applied during interval phase, or (3) no BFR applied.

HIE with BFR during exercise phase; HIE with BFR during interval phase

Eligibility Criteria

• Age: 20 Years - 25 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male adults.
• Age between 20-25.
• Have normal body mass index (BMI).
• Physically active (i.e., exercise regularly for at least three times per week) and total score more than 600MET-min/week based on The International Physical Activity Questionnaire (IPAQ).
• VO2max value above 42 ml/kg/min during cycling test (Above fair VO2max level)(American College of Sports Medicine, 2010).

You may not qualify if:

• BMI is greater than 25kg/m2.
• Have exercise-related disorders such as coronary heart disease, peripheral vascular diseases, rhabdomyolysis, respiratory inflammation, or have neurological disorders.
• Have implanted electrical devices.
• Have significant cognitive impairment.

Sponsors & Collaborators

• Universiti Sains Malaysia: lead

Study Sites (1)

Universiti Sains Malaysia

Kota Bharu, Kelantan, 16150, Malaysia

RECRUITING

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Shazlin Shaharudin

  Universiti Sains Malaysia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shazlin Shaharudin, PhD

CONTACT

+601124222894; shazlin@usm.my

Shuoqi Li, MSc

CONTACT

+6097677578; lsq728738864@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: April 15, 2021
• First Posted: April 22, 2021
• Study Start: April 1, 2021
• Primary Completion: December 31, 2021
• Study Completion: March 31, 2022
• Last Updated: April 22, 2021

Record last verified: 2021-04

Data Sharing

• IPD Sharing: Will not share

Locations

MY (1)