Sensory Memory in Speech Motor Learning

NCT04818268 | Terminated

• 2 other identifiers: 2000025475_aR01DC017439
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

Conditions

Speech; Consolidation

Outcome Measures

Primary Outcomes (2)

• Speech Motor Learning

  Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.

  Performance as measured at the end of learning (single day experiment)

• Sensory Memory

  Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.

  Single day experiment

Study Arms (5)

Adaptation to Altered Auditory Feedback

EXPERIMENTAL

Adaptation to Altered Auditory Feedback

Behavioral: Adaptation

Auditory Sensory Memory

EXPERIMENTAL

Auditory Sensory Memory

Behavioral: Adaptation

Somatosensory Sensory Memory

EXPERIMENTAL

Somatosensory Sensory Memory

Behavioral: Adaptation

Adaptation to Altered Auditory Feedback + cTBS to 46v

EXPERIMENTAL

Adaptation to Altered Auditory Feedback + cTBS to 46v

Behavioral: Adaptation; Other: cTBS

Sensory Memory + cTBS to 46v

EXPERIMENTAL

Sensory Memory + cTBS to 46v

Behavioral: Adaptation; Other: cTBS

Interventions

Adaptation BEHAVIORAL

Sensorimotor adaptation in speech

Adaptation to Altered Auditory Feedback; Adaptation to Altered Auditory Feedback + cTBS to 46v; Auditory Sensory Memory; Sensory Memory + cTBS to 46v; Somatosensory Sensory Memory

cTBS OTHER

continuous theta-burst stimulation

Adaptation to Altered Auditory Feedback + cTBS to 46v; Sensory Memory + cTBS to 46v

Eligibility Criteria

• Age: 21 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• right handed adults
• no known physical or neurological abnormalities

You may not qualify if:

• patients with:
• cardiac pacemaker
• surgical clips or values on the heart
• implants
• metal or metallic fragments in any part of the body
• pregnancy
• claustrophobia
• a personal or family history of epilepsy
• currently taking antipsychotic drugs
• currently taking antidepressant drugs
• currently taking antianxiety drugs
• history of concussion.

Sponsors & Collaborators

• Yale University: lead
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator

Study Sites (1)

McGill University

Montreal, Quebec, H3A1G1, Canada

Location

MeSH Terms

Conditions

Speech

Interventions

Acclimatization

Condition Hierarchy (Ancestors)

Verbal Behavior; Communication; Behavior

Intervention Hierarchy (Ancestors)

Adaptation, Physiological; Physiological Phenomena; Adaptation, Biological; Biological Phenomena

Study Officials

• David Ostry

  Haskins Laboratories

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 19, 2021
• First Posted: March 26, 2021
• Study Start: August 1, 2019
• Primary Completion: July 31, 2025
• Study Completion: July 31, 2025
• Last Updated: December 11, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)