Modulation of Sensory Acuity With Transcranial Magnetic Stimulation (TMS)

NCT05723575 | Completed Results

• 4 other identifiers: 2017-1128 TMS (Exp 7)Protocol Version 8/25/2021A4818001R01DC019134-01A1
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to understand how the brain processes and controls speech in healthy people. The investigators are doing this research because it will help identify the mechanisms that allow people to perceive their own speech errors and to learn new speech sounds, which may be applied to people who have communication disorders. 15 participants will be enrolled into this part of the study and can expect to be on study for 4 visits of 2-4 hours each.

Conditions

Speech

Keywords

speech motor control; vocal learning

Outcome Measures

Primary Outcomes (2)

• Somatosensory Acuity: Spatial Amplitude Discrimination Threshold (SDT)

  The investigators will measure thresholds in spatial amplitude discrimination (SDT). These thresholds represent the smallest difference that participants can detect in the amplitude of vibration on the tongue. Vibratory stimulation is delivered by the corticalmetrics Brain Gauge device, which has two probes, one on the left and one on the right side of the tongue. Participants will complete three total sessions targeting primary somatosensory cortex (S1): one using intermittent theta-burst stimulation (iTBS), one using continuous theta-burst stimulation (cTBS), and one with sham stimulation. Tactile acuity measured in this way is used as a proxy for full somatosensation, given the difficulty in measuring proprioception in the oral system. Tactile acuity has been suggested to be important for speech production, as tactile contact is maintained parasagittally during vowel production and tactile deprivation leads to imprecise speech movements.

  up to 1 hour

• Somatosensory Acuity: Temporal Discrimination Threshold (TDT)

  The investigators will measure thresholds in temporal discrimination (SDT). These thresholds represent the smallest difference that participants can detect in the timing of vibrations on the tongue. Vibratory stimulation is delivered by the corticalmetrics Brain Gauge device, which has two probes, one on the left and one on the right side of the tongue. Participants will complete three total sessions targeting primary somatosensory cortex (S1): one using intermittent theta-burst stimulation (iTBS), one using continuous theta-burst stimulation (cTBS), and one with sham stimulation. Tactile acuity measured in this way is used as a proxy for full somatosensation, given the difficulty in measuring proprioception in the oral system. Tactile acuity has been suggested to be important for speech production, as tactile contact is maintained parasagittally during vowel production and tactile deprivation leads to imprecise speech movements.

  up to 1 hour

Study Arms (1)

Healthy Adult Speakers

EXPERIMENTAL

healthy adult participants across the lifespan in three groups:18-35, 36-55, and 56+

Device: TMS; Behavioral: somatosensory acuity measurement

Interventions

TMS DEVICE

This paradigm uses theta-burst transcranial magnetic stimulation (tbTMS) to modulate the excitability of sensory cortices to examine the effect on sensory acuity and sensorimotor adaptation. Participants will complete three total sessions targeting primary somatosensory cortex (S1): one using intermittent theta-burst stimulation (iTBS), one using continuous theta-burst stimulation (cTBS), and one with sham stimulation.

Also known as: transcranial magnetic stimulation (continuous and intermittent theta-burst stimulation), electromyography (EMG)

Healthy Adult Speakers

somatosensory acuity measurement BEHAVIORAL

Somatosensory acuity will be measured through a tactile discrimination task using the corticalmetrics Brain Gauge. Participants lightly press their tongue onto two vibrating probes and report which one vibrated first or with greater amplitude.

Healthy Adult Speakers

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• English-speaking adults
• normal hearing and speech
• no history of stroke or neurological conditions

You may not qualify if:

• Native language other than English
• Any neurological disorders other than the disorder of interest
• Any history of hearing disorders
• Uncorrected vision problems that prevent participants from seeing visually-presented stimuli
• Significant cognitive impairments that prevent participants from carrying out the task or from giving informed consent
• Vulnerable populations (minors and prisoners)
• Implanted paramagnetic materials (metal clips, plates, pacemakers, etc.)
• Increased risk in the event of a seizure
• Serious heart disease
• Increased intracranial pressure
• Pregnancy
• History of seizures
• Family history of epilepsy
• Epileptogenic medications
• Chronic or transient disruption of sleep (including jet lag)

Sponsors & Collaborators

• University of Wisconsin, Madison: lead
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator

Study Sites (1)

University of Wisconsin

Madison, Wisconsin, 53705, United States

Location

Related Links

• Link to study record for experiment 5 \[NCT05286658\]

MeSH Terms

Conditions

Speech

Interventions

Transcranial Magnetic Stimulation; Electromyography

Condition Hierarchy (Ancestors)

Verbal Behavior; Communication; Behavior

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics; Electrodiagnosis; Diagnostic Techniques and Procedures; Diagnosis; Myography

Results Point of Contact

• Title: Carrie Niziolek, PhD
• Organization: University of Wisconsin - Madison

cniziolek@wisc.edu

(608) 262-7583

Study Officials

• Carrie Niziolek, PhD

  University of Wisconsin, Madison

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 1, 2023
• First Posted: February 10, 2023
• Study Start: November 18, 2022
• Primary Completion: May 26, 2023
• Study Completion: May 26, 2023
• Last Updated: December 17, 2024
• Results First Posted: December 17, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will share

Locations

US (1)