Study Stopped
End of funding
Sensory Basis of Speech Motor Learning
Brain Structures in Speech Motor Memory Consolidation
2 other identifiers
interventional
160
1 country
1
Brief Summary
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Aug 2019
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2019
CompletedFirst Submitted
Initial submission to the registry
July 30, 2020
CompletedFirst Posted
Study publicly available on registry
August 4, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2025
CompletedDecember 11, 2025
December 1, 2025
6 years
July 30, 2020
December 5, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
Motor Learning
Learning is assessed as percentage change in speech sounds (speech formant frequencies) or movements (movement curvature) relative to baseline.
Performance as measured at the end of learning (30 minute session)
Retention of Learning
Retention is measured on a 0 to 100 scale relative to the end of learning.
24 hours after learning (re-test lasts 30 minutes)
Study Arms (4)
Adaptation to Altered Sensory Feedback + cTBS to S1
EXPERIMENTALAdaptation to Altered Sensory Feedback + cTBS to S1
Adaptation to Altered Sensory Feedback + cTBS to A1
EXPERIMENTALAdaptation to Altered Sensory Feedback + cTBS to A1
Adaptation to Altered Sensory Feedback + cTBS to M1
EXPERIMENTALAdaptation to Altered Sensory Feedback + cTBS to M1
Adaptation to Altered Sensory Feedback + Sham cTBS
EXPERIMENTALAdaptation to Altered Sensory Feedback + Sham cTBS
Interventions
Sensorimotor adaptation in speech
continuous theta-burst stimulation
Eligibility Criteria
You may qualify if:
- right handed adults
- no known physical or neurological abnormalities
You may not qualify if:
- patients with:
- cardiac pacemaker
- surgical clips or values on the heart
- implants
- metal or metallic fragments in any part of the body
- pregnancy
- claustrophobia
- a personal or family history of epilepsy
- currently taking antipsychotic drugs
- currently taking antidepressant drugs
- currently taking antianxiety drugs
- history of concussion.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Yale Universitylead
- McGill Universitycollaborator
- National Institute on Deafness and Other Communication Disorders (NIDCD)collaborator
Study Sites (1)
McGill University
Montreal, Quebec, H3A1G1, Canada
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David Ostry
Haskins Laboratories
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 30, 2020
First Posted
August 4, 2020
Study Start
August 1, 2019
Primary Completion
July 31, 2025
Study Completion
July 31, 2025
Last Updated
December 11, 2025
Record last verified: 2025-12
Data Sharing
- IPD Sharing
- Will not share