Sensory Basis of Speech Motor Learning

NCT04497428 | Terminated Results

• 2 other identifiers: 2000025475R01DC017439
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.

Conditions

Speech; Consolidation

Outcome Measures

Primary Outcomes (2)

• Mean Percent Change in F1 to Assess Motor Learning

  Learning is assessed as change in speech sounds (speech formant frequencies, F1) relative to baseline. The first formant frequency (F1) is the lowest resonant frequency of the vocal tract. Lower F1 Numbers Indicate a high or "closed" tongue position). Higher F1 Numbers indicate a low or "open" jaw position. Absolute numbers vary depending on a person's age and vocal tract size. Percent change calculated as ((F1 end of learning value minus F1 baseline value)/ F1 baseline value)\*100).

  Baseline and end of learning (30 minute session)

• Mean Percent Change in F1 to Assess Retention of Learning

  First formant frequency change (F1) relative to baseline is the dependent measure of retention. Percent change calculated as ((F1 end of retention value minus F1 baseline value)/ F1 baseline value)\*100).

  Baseline and 24 hours after learning (re-test lasts 30 minutes)

Study Arms (4)

Adaptation to Altered Auditory Feedback + cTBS to S1

EXPERIMENTAL

Adaptation to Altered Auditory Feedback + cTBS to S1

Behavioral: Adaptation; Other: cTBS

Adaptation to Altered Auditory Feedback + cTBS to A1

EXPERIMENTAL

Adaptation to Altered Auditory Feedback + cTBS to A1

Behavioral: Adaptation; Other: cTBS

Adaptation to Altered Auditory Feedback + cTBS to M1

EXPERIMENTAL

Adaptation to Altered Auditory Feedback + cTBS to M1

Behavioral: Adaptation; Other: cTBS

Adaptation to Altered Auditory Feedback (Control)

EXPERIMENTAL

Adaptation to Altered Auditory Feedback (Control)

Behavioral: Adaptation

Interventions

Adaptation BEHAVIORAL

Sensorimotor adaptation in speech

Adaptation to Altered Auditory Feedback (Control); Adaptation to Altered Auditory Feedback + cTBS to A1; Adaptation to Altered Auditory Feedback + cTBS to M1; Adaptation to Altered Auditory Feedback + cTBS to S1

cTBS OTHER

continuous theta-burst stimulation

Adaptation to Altered Auditory Feedback + cTBS to A1; Adaptation to Altered Auditory Feedback + cTBS to M1; Adaptation to Altered Auditory Feedback + cTBS to S1

Eligibility Criteria

• Age: 21 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• right handed adults
• no known physical or neurological abnormalities

You may not qualify if:

• patients with:
• cardiac pacemaker
• surgical clips or values on the heart
• implants
• metal or metallic fragments in any part of the body
• pregnancy
• claustrophobia
• a personal or family history of epilepsy
• currently taking antipsychotic drugs
• currently taking antidepressant drugs
• currently taking antianxiety drugs
• history of concussion.

Sponsors & Collaborators

• Yale University: lead
• McGill University: collaborator
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator

Study Sites (1)

McGill University

Montreal, Quebec, H3A1G1, Canada

Location

MeSH Terms

Conditions

Speech

Interventions

Acclimatization

Condition Hierarchy (Ancestors)

Verbal Behavior; Communication; Behavior

Intervention Hierarchy (Ancestors)

Adaptation, Physiological; Physiological Phenomena; Adaptation, Biological; Biological Phenomena

Results Point of Contact

• Title: David Ostry
• Organization: Yale University

david.ostry@yale.edu

2038656163

Study Officials

• David Ostry

  Haskins Laboratories

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 30, 2020
• First Posted: August 4, 2020
• Study Start: August 1, 2019
• Primary Completion: July 31, 2025
• Study Completion: July 31, 2025
• Last Updated: September 29, 2026
• Results First Posted: September 29, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)