Behavioral and Neural Responses to External Alterations of Speech Variability

NCT05286658 | Completed Results

• 4 other identifiers: 2017-1128 MEG Imaging (Exp 5)Protocol Version 8/25/2021A4818001R01DC019134-01A1
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this research study is to understand how the brain processes and controls speech in healthy people. The investigators are doing this research because it will help identify the mechanisms that allow people to perceive their own speech errors and to learn new speech sounds, which may be applied to people who have communication disorders. 15 participants will be enrolled into this part of the study and can expect to be on study for 3-4 visits of 2-4 hours each.

Conditions

Speech

Keywords

speech motor control; vocal learning

Outcome Measures

Primary Outcomes (1)

• Speaking-Induced Suppression (SIS) Change, Defined as the Percent Change of SIS (the Z-score Difference in Average M100 Amplitude in the Speak Condition Compared With the Listen Condition) From Baseline to Test Phases

  The dependent measure is the speaking-induced suppression (SIS) defined as the z-score difference in average M100 amplitude in the speak condition compared with the listen condition. The M100 peak is defined as the peak activity between 75 and 150 ms after stimulus onset; peaks will be confirmed by visual inspection. The percent change in this SIS from the pre-test (baseline phase at the beginning of the MEG scan) to the post-test (test phase at the end of the MEG scan) is evaluated for each of three visits: "in", "out", and "control".

  Data were collected over 3 individual hour-long MEG sessions over 3 weeks (pre-test vs. post-test compared within the same session).

Study Arms (1)

Healthy Adult Speakers

EXPERIMENTAL

healthy adult participants across the lifespan in three groups:18-35, 36-55, and 56+

Behavioral: MEG/EEG; Behavioral: MRI; Behavioral: Speaking Tasks

Interventions

MEG/EEG BEHAVIORAL

The participant will sit still while their head is slid into the helmet-shaped bottom of the MEG device. The MEG contains sensors that passively detect weak magnetic fields outside the head produced by brain activity. The computer records the brain's electrical activity on the screen as wavy lines. The investigators will also ask you to wear sensors to capture eye-blinks (electrooculogram) and heartbeats (electrocardiogram) to facilitate removal from the MEG signal during analysis. Participant will sit in front of a projector screen and be asked to put on a pair of headphones. Participant will be shown real words or nonsense words to read, the investigators may play sounds through headphones for the participant to repeat. Participant speech will be recorded by a microphone. The investigators may ask the participant to identify what they heard by pressing a button on a button-box. These tasks are expected to take about one hour to complete.

Also known as: magnetoencephalogram / electroencephalogram

Healthy Adult Speakers

MRI BEHAVIORAL

An MRI is a test that uses a magnetic field and pulses of radio wave energy to make pictures of organs and structures inside the body. The participant will be able to hear and speak to the research staff at all times during the MRI procedures. The MRI test will take about 15 minutes.

Also known as: magnetic resonance imaging

Healthy Adult Speakers

Speaking Tasks BEHAVIORAL

The participant may be asked to perform some of the tasks from MEG again, this time outside of the scanner. As before, the participant may see real words or nonsense words to read, and the investigators may play sounds through headphones and ask the participant to repeat them. Participant speech will be recorded by a microphone. The investigators may ask the participant to identify what they heard by pressing a button on a button-box. These tasks are expected to take about one hour to complete.

Healthy Adult Speakers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• English-speaking adults
• diagnosed communicative disorder, target populations may include:
• stroke survivors with aphasia
• individuals with cerebellar ataxia
• individuals with parkinson's disease
• individuals who use cochlear implants to hear
• adults who stutter
• English-speaking adults
• normal hearing and speech
• no history of stroke or neurological conditions

You may not qualify if:

• Native language other than English
• Any neurological disorders other than the disorder of interest
• Any history of hearing disorders
• Uncorrected vision problems that prevent participants from seeing visually-presented stimuli
• Significant cognitive impairments that prevent participants from carrying out the task or from giving informed consent
• Vulnerable populations (minors and prisoners)
• Implanted paramagnetic materials (metal clips, plates, pacemakers, etc.)
• Head too large for MEG recording helmet
• Claustrophobia or intolerance of MRI scanner noise
• Low signal to noise ratio in pilot MEG recordings
• High levels of artifacts (eye-blinks, etc.)
• Inability to produce the speech sounds proposed with minimal movement
• Left-handedness
• Implanted paramagnetic materials (metal clips, plates, pacemakers, etc.)
• Increased risk in the event of a seizure

Sponsors & Collaborators

• University of Wisconsin, Madison: lead
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator

Study Sites (2)

University of Wisconsin

Madison, Wisconsin, 53705, United States

Location

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

Related Links

• Link to study record for experiment 7 \[NCT05723575\]

MeSH Terms

Conditions

Speech

Interventions

Magnetoencephalography; Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Verbal Behavior; Communication; Behavior

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques; Spectrum Analysis; Chemistry Techniques, Analytical

Results Point of Contact

• Title: Carrie Niziolek, PhD
• Organization: University of Wisconsin - Madison

cniziolek@wisc.edu

(608) 262-7583

Study Officials

• Carrie Niziolek, PhD

  University of Wisconsin, Madison

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2022
• First Posted: March 18, 2022
• Study Start: October 19, 2021
• Primary Completion: July 19, 2022
• Study Completion: July 19, 2022
• Last Updated: February 13, 2024
• Results First Posted: February 13, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will share

Locations

US (2)