Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
1 other identifier
observational
43
1 country
1
Brief Summary
Covid-19 associated Acute Respiratory Distress Syndrome (ARDS) may present with profound hypoxemia not fully explained with pulmonary infiltrates. Accordingly, how prone positioning improves oxygenation in these patients is not fully known. The investigators conducted a study among patients with severe Covid-19 ARDS receiving prone position for at least 16 hours. End Expiratory Lung Volume (EELV) was measured with Nitrogen wash-in/wash-out technique before (Supine Position 1- SP1), during (Prone Position - PP) and after (Supine Position 2 - SP2) prone positioning.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Sep 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2020
CompletedFirst Submitted
Initial submission to the registry
March 25, 2021
CompletedFirst Posted
Study publicly available on registry
March 26, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2022
CompletedMarch 4, 2022
March 1, 2022
1.1 years
March 25, 2021
March 3, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Partial Pressure of Oxygen/ Fraction of Inspired Oxygen
Oxygenation
1 day
End Expiratory Lung Volume
Oxygenation
1 day
Secondary Outcomes (2)
Lung Compliance
1 day
Dead Space Ventilation
1 day
Eligibility Criteria
Adult Patients receiving invasive mechanic ventilation due to Covid-19 ARDS
You may qualify if:
- Patients were considered eligible if they met the Berlin definition criteria for ARDS and intubated due to increased work of breathing and/or worsening hypoxemia. All patients had a positive Covid-19 real time Polymerase Chain Reaction test
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Istanbul University-Cerrahpaşa
Istanbul, Turkey (Türkiye)
Related Publications (1)
Dilken O, Rezoagli E, Yartas Dumanli G, Urkmez S, Demirkiran O, Dikmen Y. Effect of prone positioning on end-expiratory lung volume, strain and oxygenation change over time in COVID-19 acute respiratory distress syndrome: A prospective physiological study. Front Med (Lausanne). 2022 Dec 2;9:1056766. doi: 10.3389/fmed.2022.1056766. eCollection 2022.
PMID: 36530873DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Olcay Dilken, Dr.
Istanbul University - Cerrahpasa
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 25, 2021
First Posted
March 26, 2021
Study Start
September 1, 2020
Primary Completion
September 30, 2021
Study Completion
March 1, 2022
Last Updated
March 4, 2022
Record last verified: 2022-03
Data Sharing
- IPD Sharing
- Will not share