Ventilation-Perfusion Matching in Early-stage Prone Position Ventilation

NCT05816928 | Completed DMC

• 1 other identifier: EIT20230403
• Study Type: observational
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

Prone positioning has been widely used in critical care medicine to improve oxygenation in patients with acute respiratory distress syndrome (ARDS). This study aimed to compare the effect of pronation on lung ventilation-perfusion matching between COVID19-associated acute respiratory distress syndrome (CARDS) and ARDS from other etiologies (non-CARDS) using electrical impedance tomography (EIT).

Conditions

Acute Respiratory Distress Syndrome

Keywords

Acute Respiratory Distress Syndrome; ICU; COVID19; Electrical impedance tomography

Outcome Measures

Primary Outcomes (4)

• DeadSpace

  The area of Deadspace will be assessed using electrical impedance tomography

  3 months

• Shunt

  Shunt will be assessed using electrical impedance tomography

  3 months

• Ventilation-perfusion matching (VQmatch)

  VQmatch will be assessed using electrical impedance tomography

  3 months

• Global inhomogeneity index (VQmatch-GI)

  Within the defined VQmatch region assessed by electrical impedance tomography, the global inhomogeneity index (VQmatch-GI) was calculated to assess the degree of uniformity within the region.

  3 months

Secondary Outcomes (4)

• Ventilation

  3 months

• Perfusion

  3 months

• Center of Ventilation (CoV)

  3 months

• Standard deviation of regional ventilation delay

  3 months

Study Arms (2)

COVID19-associated ARDS (CARDS)

This group included COVID19 patients with acute respiratory distress syndrome. Patients were put under prone position while their pulmonary function was measured using EIT before and after proning.

Non-COVID19-associated ARDS (non-CARDS)

This group included patients with acute respiratory distress syndrome from other etiologies. Patients were put under prone position while their pulmonary function was measured using EIT before and after proning.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population includes COVID19-associated ARDS patients and ARDS patients of other etiologies in the intensive care unit.

You may qualify if:

• Above the age of 18
• Diagnosed with ARDS based on the Berlin Definition of ARDS
• Under mechanical ventilation

You may not qualify if:

• Contraindications to EIT examination and prone position
• Refusal of signing the informed consent

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

PUMC

Beijing, Beijing Municipality, 100730, China

Location

Related Publications (1)

• Yang Y, Li H, Chi Y, Frerichs I, Zhao Z, Li Y, Zhang C, Chu H, He H, Long Y. Ventilation-perfusion matching in early-stage of prone position ventilation: a prospective cohort study between COVID-19 ARDS and ARDS from other etiologies. Physiol Meas. 2025 Jan 29;13(1). doi: 10.1088/1361-6579/ada8f1.

  PMID: 39793207 DERIVED

MeSH Terms

Conditions

Respiratory Distress Syndrome; COVID-19

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections

Study Officials

• Yun Long, MD

  Peking Union Medical College

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 5, 2023
• First Posted: April 18, 2023
• Study Start: January 12, 2021
• Primary Completion: April 12, 2021
• Study Completion: April 12, 2021
• Last Updated: April 18, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)