Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
KRYSTAL-12
A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
2 other identifiers
interventional
453
23 countries
377
Brief Summary
This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3
Started Feb 2021
Longer than P75 for phase_3
377 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 21, 2020
CompletedFirst Posted
Study publicly available on registry
December 28, 2020
CompletedStudy Start
First participant enrolled
February 23, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2023
CompletedResults Posted
Study results publicly available
January 22, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
October 30, 2026
ExpectedAugust 11, 2026
July 1, 2026
2.8 years
December 21, 2020
December 20, 2024
July 17, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Progression-Free Survival (PFS) as Per Blinded Independent Central Review
Progression-free survival (PFS) is defined as the time from randomization to the date of progression or death due to any cause, whichever occurs first. 95% CI was obtained using Brookmeyer and Crowley method. Participants who are not observed to have progressed or died are censored at the date of last evaluable tumor assessment. Disease progression assessed as per RECISIST 1.1 was defined as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm.
From randomization to the date of progression or death due to any cause, whichever occurs first (up to approximately 143 weeks)
Secondary Outcomes (13)
Overall Survival (OS)
From randomization till death due to any cause (up to approximately 143 weeks)
Objective Response Rate (ORR) as Per Blinded Independent Central Review
From randomization till death or till disease progression or initiation of follow-up anti-cancer therapy or withdrawal of consent prior to minimum efficacy follow-up (up to 143 weeks)
Duration of Response (DOR) as Per Blinded Independent Central Review
First documentation of objective response (CR or PR) to the first documentation of PD or to death due to any cause (Up to approximately 22 months)
1-Year Survival Rate
Up to 49 months
Number of Participants With Treatment Emergent Adverse Events (TEAEs)
From first dose of treatment (Day 1) till 28 days after last dose (Up to approximately 110 weeks)
- +8 more secondary outcomes
Study Arms (2)
MRTX849
EXPERIMENTALDocetaxel
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
- Candidacy to receive treatment with docetaxel.
- Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
- ECOG performance status 0-2
You may not qualify if:
- Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
- Active brain metastases.
- Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (380)
Local Institution - 012-898
Cerritos, California, 90703, United States
Local Institution - 012-910
Duarte, California, 91010, United States
Local Institution - 012-898 D
Glendale, California, 91204, United States
Local Institution - 012-910-A
Huntington Beach, California, 92648, United States
Local Institution - 012-910-C
Irvine, California, 92618, United States
Local Institution - 012-910-B
Long Beach, California, 90808, United States
Local Institution - 012-910-F
Long Beach, California, 90813, United States
Local Institution - 012-910-D
Newport Beach, California, 92663, United States
Local Institution - 012-898 C
Santa Ana, California, 92705, United States
Local Institution - 012-858
Santa Rosa, California, 95403, United States
Local Institution - 012-910-E
Torrance, California, 90505, United States
Local Institution - 012-951-B
Denver, Colorado, 80218, United States
Local Institution - 012-951
Lafayette, Colorado, 80026, United States
Local Institution - 012-872
Lone Tree, Colorado, 80124, United States
Local Institution - 012-951-A
Wheat Ridge, Colorado, 80033-6005, United States
Local Institution - 012-562-B
Fleming Island, Florida, 32003, United States
Local Institution - 012-968
Fort Lauderdale, Florida, 33308, United States
Local Institution - 012-562-D
Jacksonville, Florida, 32204, United States
Local Institution - 012-853
Jacksonville, Florida, 32204, United States
Local Institution - 012-562-E
Jacksonville, Florida, 32207, United States
Local Institution - 012-562-A
Jacksonville, Florida, 32256, United States
Local Institution - 012-562-C
Jacksonville, Florida, 32256, United States
Local Institution - 012-562-F
Jacksonville, Florida, 32256, United States
Local Institution - 012-562-G
Jacksonville, Florida, 32256, United States
Local Institution - 012-562
Jacksonville, Florida, 32256, United States
Local Institution - 012-825
Miami Beach, Florida, 33140, United States
Local Institution - 012-973
Orlando, Florida, 32806, United States
Local Institution - 012-877
Pensacola, Florida, 32503, United States
Local Institution - 012-839
Plantation, Florida, 33322, United States
Local Institution - 012-941
Athens, Georgia, 30607, United States
Local Institution - 012-835 - A
Austell, Georgia, 30106, United States
Local Institution - 012-835 - B
Carrollton, Georgia, 30117, United States
Local Institution - 012-835 - C
Cartersville, Georgia, 30121, United States
Local Institution - 012-835 - D
Douglasville, Georgia, 30134, United States
Local Institution - 012-835
Marietta, Georgia, 30060, United States
Local Institution - 012-917
Chicago, Illinois, 60612, United States
Local Institution - 012-972
Chicago, Illinois, 60637, United States
Local Institution - 012-972 C
Harvey, Illinois, 60426, United States
Local Institution - 012-972 A
New Lenox, Illinois, 60451, United States
Local Institution - 012-883
Niles, Illinois, 60714, United States
Local Institution - 012-972 B
Orland Park, Illinois, 60462, United States
Local Institution - 012-943
Goshen, Indiana, 46526, United States
Local Institution - 012-569
Indianapolis, Indiana, 46237, United States
Local Institution - 012-569 - B
Lafayette, Indiana, 47905, United States
Local Institution - 012-569 - C
Lafayette, Indiana, 47905, United States
Local Institution - 012-569 - A
Mooresville, Indiana, 46158, United States
Local Institution - 012-782
Munster, Indiana, 46321, United States
Local Institution - 012-942-B
Chanute, Kansas, 66720, United States
Local Institution - 012-942-C
Dodge City, Kansas, 67801, United States
Local Institution - 012-942-D
El Dorado, Kansas, 67042, United States
Local Institution - 012-942-E
Independence, Kansas, 67301, United States
Local Institution - 012-942-F
Kingman, Kansas, 67068, United States
Local Institution - 012-942-G
Liberal, Kansas, 67901, United States
Local Institution - 012-942-H
McPherson, Kansas, 67460, United States
Local Institution - 012-942-I
Newton, Kansas, 67114, United States
Local Institution - 012-942-J
Parsons, Kansas, 67357, United States
Local Institution - 012-942-K
Pratt, Kansas, 67124, United States
Local Institution - 012-942-L
Salina, Kansas, 67401, United States
Local Institution - 012-942-M
Wellington, Kansas, 67152, United States
Local Institution - 012-820
Westwood, Kansas, 66205, United States
Local Institution - 012-942-A
Wichita, Kansas, 67208, United States
Local Institution - 012-942
Wichita, Kansas, 67214, United States
Local Institution - 012-942-N
Winfield, Kansas, 67156, United States
Local Institution - 012-965
Lexington, Kentucky, 40503, United States
Local Institution - 012-911 A
New Orleans, Louisiana, 70112, United States
Local Institution - 012-911
New Orleans, Louisiana, 70112, United States
Local Institution - 012-954 - A
Kennebunk, Maine, 04043, United States
Local Institution - 012-954
Scarborough, Maine, 04074, United States
Local Institution - 012-954 - B
Topsham, Maine, 04086, United States
Local Institution - 012-856
Frederick, Maryland, 21702, United States
Local Institution - 012-974-B
Novi, Michigan, 48374, United States
Local Institution - 012-974-C
Novi, Michigan, 48374, United States
Local Institution - 012-974-A
Southfield, Michigan, 48075, United States
Local Institution - 012-974
Southfield, Michigan, 48075, United States
Local Institution - 012-952
Bolivar, Missouri, 65613, United States
Local Institution - 012-841 - A
Billings, Montana, 59101, United States
Local Institution - 012-841
Billings, Montana, 59101, United States
Local Institution - 012-846
Billings, Montana, 59102, United States
Local Institution - 012-975
East Brunswick, New Jersey, 08816, United States
Local Institution - 012-975 - A
Edison, New Jersey, 08820, United States
Local Institution - 012-975 - B
Monroe, New Jersey, 08831, United States
Local Institution - 012-975 - C
Somerset, New Jersey, 08873, United States
Local Institution - 012-975 - D
Somerville, New Jersey, 08876, United States
Local Institution - 012-577
Teaneck, New Jersey, 07666, United States
Local Institution - 012-962
Syracuse, New York, 13210-2306, United States
Local Institution - 012-849
Cleveland, Ohio, 44106, United States
Local Institution - 012-836
Kettering, Ohio, 45429, United States
Local Institution - 012-967
Salem, Oregon, 97301, United States
Local Institution - 012-960
Providence, Rhode Island, 02903, United States
Local Institution - 012-960-A
Providence, Rhode Island, 02906, United States
Local Institution - 012-891
Greenville, South Carolina, 29605, United States
Local Institution - 012-940
Sioux Falls, South Dakota, 57105, United States
Local Institution - 012-888
Arlington, Texas, 76012, United States
Local Institution - 012-892
Austin, Texas, 78745, United States
Local Institution - 012-999
Irving, Texas, 75063, United States
Local Institution - 012-890
Sherman, Texas, 75090, United States
Local Institution - 012-976
Salt Lake City, Utah, 84106, United States
Local Institution - 012-976-A
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-B
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-C
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-D
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-E
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-F
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-G
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-H
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-I
Salt Lake City, Utah, 84124, United States
Local Institution - 012-814 - B
Arlington, Virginia, 22205, United States
Local Institution - 012-953
Charlottesville, Virginia, 22908-0674, United States
Local Institution - 012-814 - A
Fairfax, Virginia, 22031, United States
Local Institution - 012-814
Fairfax, Virginia, 22031, United States
Local Institution - 012-814 - C
Gainesville, Virginia, 20155, United States
Local Institution - 012-814 - D
Leesburg, Virginia, 20176, United States
Local Institution - 012-016
Mackay, Queensland, 4740, Australia
Local Institution - 012-005
Bedford Park, 5042, Australia
Local Institution - 012-004
Clayton, 3168, Australia
Local Institution - 012-014
Douglas, 4814, Australia
Local Institution - 012-013
St Leonards, 2065, Australia
Local Institution - 012-019
Tweed Heads, 2485, Australia
Local Institution - 012-017
Wollongong, 2500, Australia
Local Institution - 012-009
Woolloongabba, 4102, Australia
Local Institution - 012-142
Klagenfurt, 9020, Austria
Local Institution - 012-140
Salzburg, 5020, Austria
Local Institution - 012-146
Vienna, 1160, Austria
Local Institution - 012-154
Brussels, 1090, Belgium
Local Institution - 012-157
Edegem, 2650, Belgium
Local Institution - 012-155
Ghent, 9000, Belgium
Local Institution - 012-151
Gilly, 6060, Belgium
Local Institution - 012-158
Hasselt, 3500, Belgium
Local Institution - 012-152
Roeselare, 8800, Belgium
Local Institution - 012-153
Ronse, 9600, Belgium
Local Institution - 012-150
Yvoir, B-5530, Belgium
Local Institution - 012-725
Beijing, Beijing Municipality, 100039, China
Local Institution - 012-700
Beijing, Beijing Municipality, 100142, China
Local Institution - 012-738
Beijing, Beijing Municipality, 100142, China
Local Institution - 012-724
Beijing, Beijing Municipality, 100730, China
Local Institution - 012-727
Chongqing, Chongqing Municipality, 400038, China
Local Institution - 012-726
Chongqing, Chongqing Municipality, 400042, China
Local Institution - 012-029
Fuzhou, Fujian, 350014, China
Local Institution - 012-732
Xiamen, Fujian, 361003, China
Local Institution - 012-712
Guangzhou, Guangdong, 510120, China
Local Institution - 012-739
Guangzhou, Guangdong, 510515, China
Local Institution - 012-733
Liuzhou, Guangxi, 545006, China
Local Institution - 012-028
Harbin, Heilongjiang, 150081, China
Local Institution - 012-740
Xinxiang, Henan, 453100, China
Local Institution - 012-021
Zhengzhou, Henan, 450008, China
Local Institution - 012-730
Zhengzhou, Henan, 450052, China
Local Institution - 012-023
Wuhan, Hubei, 430022, China
Local Institution - 012-701
Wuhan, Hubei, 430079, China
Local Institution - 012-702
Changsha, Hunan, 410006, China
Local Institution - 012-735
Nanjing, Jiangsu, 210006, China
Local Institution - 012-734
Nanjing, Jiangsu, 210008, China
Local Institution - 012-729
Nanjing, Jiangsu, 210029, China
Local Institution - 012-728
Xuzhou, Jiangsu, 221009, China
Local Institution - 012-706
Nanchang, Jiangxi, 330006, China
Local Institution - 012-731
Nanchang, Jiangxi, 330006, China
Local Institution - 012-030
Changchun, Jilin, 130012, China
Local Institution - 012-709
Shenyang, Liaoning, 110001, China
Local Institution - 012-036
Jinan, Shandong, 250117, China
Local Institution - 012-737
Linyi, Shandong, 276001, China
Local Institution - 012-741
Qingdao, Shandong, 266555, China
Local Institution - 012-719
Shanghai, Shanghai Municipality, 200030, China
Local Institution - 012-024
Shanghai, Shanghai Municipality, 200032, China
Local Institution - 012-025
Shanghai, Shanghai Municipality, 200032, China
Local Institution - 012-710
Chengdu, Sichuan, 610041, China
Local Institution - 012-721
Chengdu, Sichuan, 610041, China
Local Institution - 012-722
Hangzhou, Zhejiang, 310003, China
Local Institution - 012-736
Hangzhou, Zhejiang, 310016, China
Local Institution - 012-034
Hangzhou, Zhejiang, 310022, China
Local Institution - 012-164
Hořovice, 268 31, Czechia
Local Institution - 012-162
Olomouc, 779 00, Czechia
Local Institution - 012-163
Prague, 128 08, Czechia
Local Institution - 012-168
Praha 8 - Liben, 180 81, Czechia
Local Institution - 012-191-A
Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
Local Institution - 012-191-B
Lyon, Rhone, 69004, France
Local Institution - 012-194
Brest, 29200, France
Local Institution - 012-191
Bron, 69500, France
Local Institution - 012-193
Caen, 14033, France
Local Institution - 012-196
Caen, 14076, France
Local Institution - 012-190
Créteil, 94000, France
Local Institution - 012-192
Dijon, 21079, France
Local Institution - 012-201
Gleizé, 69400, France
Local Institution - 012-683
La Tronche, 38700, France
Local Institution - 012-665
Lille, 59037, France
Local Institution - 012-195
Limoges, 87042, France
Local Institution - 012-199
Marseille, 13009, France
Local Institution - 012-687
Marseille, 13015, France
Local Institution - 012-200
Montpellier, 34090, France
Local Institution - 012-666
Mulhouse, 68100, France
Local Institution - 012-685
Nice, 06189, France
Local Institution - 012-681
Quimper, 29107, France
Local Institution - 012-198
Saint-Herblain, 44805, France
Local Institution - 012-684
Strasbourg, 67091, France
Local Institution - 012-197
Strasbourg, 67200, France
Local Institution - 012-209
Tours, 37044, France
Local Institution - 012-202
Villejuif, 94805, France
Local Institution - 012-219
Bad Berka, 99437, Germany
Local Institution - 012-222
Bonn, 53127, Germany
Local Institution - 012-221
Cologne, 51109, Germany
Local Institution - 012-210
Essen, 45136, Germany
Local Institution - 012-214
Gauting, 82131, Germany
Local Institution - 012-671
Giessen, 35392, Germany
Local Institution - 012-659
Grohansdorf, 22927, Germany
Local Institution - 012-215
Halle, 06120, Germany
Local Institution - 012-225
Jena, 07747, Germany
Local Institution - 012-213
Kassel, 34125, Germany
Local Institution - 012-224
Löwenstein, 74245, Germany
Local Institution - 012-216
Lübeck, 23538, Germany
Local Institution - 012-220
München, 81925, Germany
Local Institution - 012-672
Offenbach, 63069, Germany
Local Institution - 012-212
Oldenburg, 26121, Germany
Local Institution - 012-502
Athens, Attica, 11526, Greece
Local Institution - 012-236
Athens, 11527, Greece
University General Hospital of Heraklion (PAGNI)
Heraklion, 71110, Greece
Local Institution - 012-235
Larissa, 41110, Greece
Local Institution - 012-237
Nea Kifissia, 145 64, Greece
Local Institution - 012-234
Piraeus, 185 47, Greece
Local Institution - 012-239
Piraeus, 185 47, Greece
Local Institution - 012-504
Thessaloniki, 54622, Greece
Local Institution - 012-230
Thessaloniki, 57001, Greece
Local Institution - 012-500
Thessaloniki, 57010, Greece
Local Institution - 012-503
Volos, 38333, Greece
Local Institution - 012-048
Central, 0, Hong Kong
Local Institution - 012-043
Hong Kong, 0, Hong Kong
Local Institution - 012-040
Kowloon, 0, Hong Kong
Local Institution - 012-242
Budapest, 1083, Hungary
Local Institution - 012-244
Budapest, 1121, Hungary
Local Institution - 012-241
Budapest, 1122, Hungary
Local Institution - 012-243
Gyöngyös, 3200, Hungary
Local Institution - 012-763
Gyula, 5700, Hungary
Local Institution - 012-759
Székesfehérvár, 8000, Hungary
Local Institution - 012-240
Törökbálint, 2045, Hungary
Local Institution - 012-255
Tallaght, Dublin, D24 NR04, Ireland
Local Institution - 012-250
Dublin, 4, Ireland
Local Institution - 012-252
Dublin, 9, Ireland
Local Institution - 012-259
Dublin, D08 NHY1, Ireland
Local Institution - 012-257
Galway, H91 YR71, Ireland
Local Institution - 012-258
Limerick, V94 F858, Ireland
Local Institution - 012-276
Alessandria, 15121, Italy
Local Institution - 012-292
Avellino, 83100, Italy
Local Institution - 012-274
Aviano, 33081, Italy
Local Institution - 012-275
Bari, 70124, Italy
Local Institution - 012-765
Brescia, 25123, Italy
Local Institution - 012-286
Candiolo, 10060, Italy
Local Institution - 012-284
Catania, 95122, Italy
Local Institution - 012-282
Catania, 95123, Italy
Local Institution - 012-762
Florence, 50134, Italy
Local Institution - 012-273
Genova, 16100, Italy
Local Institution - 012-285
Genova, 16132, Italy
Local Institution - 012-279
Lecce, 73100, Italy
Local Institution - 012-270
Meldola, 47014, Italy
Local Institution - 012-296
Milan, 20132, Italy
Local Institution - 012-278
Milan, 20141, Italy
Local Institution - 012-283
Milan, 20133, Italy
Local Institution - 012-271
Naples, 80131, Italy
Local Institution - 012-277
Naples, 80131, Italy
Local Institution - 012-770
Novara, 28100, Italy
Local Institution - 012-272
Parma, 43126, Italy
Local Institution - 012-281
Perugia, 06132, Italy
Local Institution - 012-766
Pesaro, 61122, Italy
Local Institution - 012-767
Ravenna, 48121, Italy
Local Institution - 012-295
Roma, 00144, Italy
Local Institution - 012-758
Verona, 37126, Italy
Local Institution - 012-306
Amsterdam, 1081 HV, Netherlands
Local Institution - 012-309
Breda, 4818 CK, Netherlands
Local Institution - 012-300
Maastricht, 6229 HX, Netherlands
Local Institution - 012-630
Nijmegen, 6525 GA, Netherlands
Local Institution - 012-308
The Hague, 2545 AA, Netherlands
Local Institution - 012-307
Utrecht, 3543 AZ, Netherlands
Local Institution - 012-631
Utrecht, 3584 CX, Netherlands
Local Institution - 012-757
Lodz, 90-302, Poland
Local Institution - 012-321
Lublin, 20-064, Poland
Local Institution - 012-760
Lublin, 20-093, Poland
Local Institution - 012-325
Otwock, 05-400, Poland
Local Institution - 012-320
Rzeszów, 35-922, Poland
Local Institution - 012-324
Skorzewo, 60-185, Poland
Local Institution - 012-329
Torun, 87-100, Poland
Local Institution - 012-322
Warsaw, 02-781, Poland
Local Institution - 012-774
Warsaw, 04-349, Poland
Local Institution - 012-644
Almada, 2805-267, Portugal
Local Institution - 012-332
Braga, 4710-243, Portugal
Local Institution - 012-330
Coimbra, 3000-075, Portugal
Local Institution - 012-645
Coimbra, 3000-075, Portugal
Local Institution - 012-333
Guimarães, 4835-044, Portugal
Local Institution - 012-642
Lisbon, 1099-023, Portugal
Local Institution - 012-338-A
Lisbon, 1350-352, Portugal
Local Institution - 012-337
Lisbon, 1400-038, Portugal
Local Institution - 012-338
Lisbon, 1998-018, Portugal
Local Institution - 012-647
Loures, 2674-514, Portugal
Local Institution - 012-334
Porto, 14341, Portugal
Local Institution - 012-331
Porto, 4099-001, Portugal
Local Institution - 012-339
Porto, 4200-072, Portugal
Local Institution - 012-641
Santa Maria da Feira, 4520-211, Portugal
Local Institution - 012-646
Setúbal, 2910-443, Portugal
Local Institution - 012-335
Vila Nova de Gaia, 4434-502, Portugal
Local Institution - 012-903
San Juan, PR, 00927, Puerto Rico
Local Institution - 012-900
San Juan, PR, 00935, Puerto Rico
Local Institution - 012-901
San Juan, 00919, Puerto Rico
Local Institution - 012-347
Baia Mare, 430031, Romania
Local Institution - 012-349
Brasov, 500152, Romania
Local Institution - 012-341
Bucharest, 010991, Romania
Local Institution - 012-342
Bucharest, 022328, Romania
Local Institution - 012-344
Cluj-Napoca, 400015, Romania
Local Institution - 012-340
Cluj-Napoca, 400641, Romania
Local Institution - 012-514
Craiova, 200385, Romania
Local Institution - 012-343
Craiova, 200746, Romania
Local Institution - 012-513
Iași, 700106, Romania
Local Institution - 012-519
Ovidiu, 905900, Romania
Local Institution - 012-515
Timișoara, 300166, Romania
Local Institution - 012-345
Timișoara, 300239, Romania
Local Institution - 012-352
Chelyabinsk, 454048, Russia
Local Institution - 012-351
Izhevsk, 426067, Russia
Local Institution - 012-362
Kislino Village, 305524, Russia
Local Institution - 012-353
Moscow, 121309, Russia
Local Institution - 012-368
Moscow, 121467, Russia
Local Institution - 012-359
Nizhny Novgorod, 603006, Russia
Local Institution - 012-356
Novosibirsk, 630099, Russia
Local Institution - 012-350
Omsk, 644013, Russia
Local Institution - 012-355
Saint Petersburg, 197022, Russia
Local Institution - 012-358
Saint Petersburg, 197376, Russia
Local Institution - 012-354
Saint Petersburg, 197758, Russia
Local Institution - 012-093
Singapore, 168583, Singapore
Local Institution - 012-095
Singapore, 188770, Singapore
Local Institution - 012-092
Singapore, 217562, Singapore
Local Institution - 012-091
Singapore, 258499, Singapore
Local Institution - 012-094
Singapore, 258500, Singapore
Local Institution - 012-111
Busan, 48108, South Korea
Local Institution - 012-522
Busan, 49241, South Korea
Local Institution - 012-101
Busan, 602702, South Korea
Local Institution - 012-113
Cheongju-si, 28644, South Korea
Local Institution - 012-110
Daegu, 41404, South Korea
Local Institution - 012-523
Daegu, 42601, South Korea
Local Institution - 012-100
Hwasun-gun, 58128, South Korea
Local Institution - 012-103
Incheon, 21565, South Korea
Local Institution - 012-102
Junggu, 400-712, South Korea
Local Institution - 012-520
Seongnam-si, 13496, South Korea
Local Institution - 012-112
Seongnam-si, 13620, South Korea
Local Institution - 012-105
Seoul, 02841, South Korea
Local Institution - 012-118
Seoul, 03722, South Korea
Local Institution - 012-106
Seoul, 05080, South Korea
Local Institution - 012-104
Seoul, 05505, South Korea
Local Institution - 012-109
Seoul, 06591, South Korea
Local Institution - 012-521
Suwon, 16247, South Korea
Local Institution - 012-107
Suwon, 16499, South Korea
Local Institution - 012-611A
Pamplona, Navarre, 31008, Spain
Local Institution - 012-613
A Coruña, 15006, Spain
Local Institution - 012-769
Alicante, 3010, Spain
Local Institution - 012-610
Badalona, 08916, Spain
Local Institution - 012-776
Barakaldo, 48903, Spain
Local Institution - 012-761
Barcelona, 08003, Spain
Local Institution - 012-614
Barcelona, 08028, Spain
Local Institution - 012-612
Barcelona, 08035, Spain
Local Institution - 012-600
Barcelona, 08036, Spain
Local Institution - 012-621
Córdoba, 14004, Spain
Local Institution - 012-764
Girona, 17007, Spain
Local Institution - 012-616
Granada, 18014, Spain
Local Institution - 012-628
Las Palmas de Gran Canaria, 35016, Spain
Local Institution - 012-775
León, 24071, Spain
Local Institution - 012-615
Lugo, 27003, Spain
Local Institution - 012-607
Madrid, 28007, Spain
Local Institution - 012-611
Madrid, 28027, Spain
Local Institution - 012-606
Madrid, 28034, Spain
Local Institution - 012-601
Madrid, 28040, Spain
Local Institution - 012-609
Madrid, 28040, Spain
Local Institution - 012-617
Madrid, 28041, Spain
Local Institution - 012-626
Majadahonda, 28222, Spain
Local Institution - 012-608
Málaga, 29009, Spain
Local Institution - 012-602
Palma de Mallorca, 07120, Spain
Local Institution - 012-604
Santander, 39008, Spain
Local Institution - 012-629
Seville, 41013, Spain
Local Institution - 012-625
Valencia, 46014, Spain
Local Institution - 012-605
Valencia, 46026, Spain
Local Institution - 012-603
Zaragoza, 50009, Spain
Local Institution - 012-390
Basel, 4031, Switzerland
Local Institution - 012-391
Thun, 3604, Switzerland
Local Institution - 012-392
Winterthur, 8401, Switzerland
Local Institution - 012-401
Birmingham, B9 5SS, United Kingdom
Local Institution - 012-415
Edinburgh, EH4 2XU, United Kingdom
Local Institution - 012-400
Glasgow, G12 0XH, United Kingdom
Local Institution - 012-408
Leicester, LE1 5WW, United Kingdom
Local Institution - 012-407
Manchester, M20 4BX, United Kingdom
Related Publications (1)
Barlesi F, Yao W, Duruisseaux M, Doucet L, Martinez AA, Gregorc V, Juan-Vidal O, Lu S, De Bondt C, de Marinis F, Linardou H, Kim YC, Jotte R, Felip E, Lo Russo G, Reck M, Michenzie MF, Yang W, Meade JN, Korytowsky B, Mok TSK; KRYSTAL-12 Investigators. Adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer (KRYSTAL-12): a randomised, open-label, phase 3 trial. Lancet. 2025 Aug 9;406(10503):615-626. doi: 10.1016/S0140-6736(25)00866-9.
PMID: 40783289DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Bristol-Myers Squibb Study Director
- Organization
- Bristol-Myers Squibb
Study Officials
- STUDY DIRECTOR
Bristol-Myers Squibb
Bristol-Myers Squibb
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
- Expanded Access
- Yes
Study Record Dates
First Submitted
December 21, 2020
First Posted
December 28, 2020
Study Start
February 23, 2021
Primary Completion
December 30, 2023
Study Completion (Estimated)
October 30, 2026
Last Updated
August 11, 2026
Results First Posted
January 22, 2025
Record last verified: 2026-07
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, CSR
- Time Frame
- See Plan Description
- Access Criteria
- See Plan Description
BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html