Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
KRYSTAL-12
A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
2 other identifiers
interventional
453
22 countries
335
Brief Summary
This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3
Started Feb 2021
Longer than P75 for phase_3
335 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 21, 2020
CompletedFirst Posted
Study publicly available on registry
December 28, 2020
CompletedStudy Start
First participant enrolled
February 23, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2023
CompletedResults Posted
Study results publicly available
January 22, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
July 2, 2026
ExpectedJanuary 22, 2025
January 1, 2025
2.8 years
December 21, 2020
December 20, 2024
January 20, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Progression-Free Survival (PFS) as Per Blinded Independent Central Review
Progression-free survival (PFS) is defined as the time from randomization to the date of progression or death due to any cause, whichever occurs first. 95% CI was obtained using Brookmeyer and Crowley method. Participants who are not observed to have progressed or died are censored at the date of last evaluable tumor assessment. Disease progression assessed as per RECISIST 1.1 was defined as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm.
From randomization to the date of progression or death due to any cause, whichever occurs first (up to approximately 143 weeks)
Secondary Outcomes (13)
Overall Survival (OS)
From randomization till death due to any cause (up to approximately 143 weeks)
Objective Response Rate (ORR) as Per Blinded Independent Central Review
From randomization till death or till disease progression or initiation of follow-up anti-cancer therapy or withdrawal of consent prior to minimum efficacy follow-up (up to 143 weeks)
Duration of Response (DOR) as Per Blinded Independent Central Review
First documentation of objective response (CR or PR) to the first documentation of PD or to death due to any cause (Up to approximately 22 months)
1-Year Survival Rate
Up to 49 months
Number of Participants With Treatment Emergent Adverse Events (TEAEs)
From first dose of treatment (Day 1) till 28 days after last dose (Up to approximately 110 weeks)
- +8 more secondary outcomes
Study Arms (2)
MRTX849
EXPERIMENTALDocetaxel
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
- Candidacy to receive treatment with docetaxel.
- Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
- ECOG performance status 0-2
You may not qualify if:
- Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
- Active brain metastases.
- Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (343)
Local Institution - 012-898
Cerritos, California, 90703, United States
City of Hope - Duarte (Main Campus)
Duarte, California, 91010, United States
Local Institution - 012-898 D
Glendale, California, 91204, United States
Local Institution - 012-910-A
Huntington Beach, California, 92648, United States
Local Institution - 012-910-C
Irvine, California, 92618, United States
City Of Hope
Long Beach, California, 90808, United States
Local Institution - 012-910-F
Long Beach, California, 90813, United States
Local Institution - 012-910-D
Newport Beach, California, 92663, United States
Local Institution - 012-898 C
Santa Ana, California, 92705, United States
Providence Medical Group - Santa Rosa
Santa Rosa, California, 95403, United States
Local Institution - 012-910-E
Torrance, California, 90505, United States
Local Institution - 012-951-B
Denver, Colorado, 80218, United States
SCL Health - Saint Joseph Hospital Cancer Center
Lafayette, Colorado, 80026, United States
Local Institution - 012-872
Lone Tree, Colorado, 80124, United States
Local Institution - 012-951-A
Wheat Ridge, Colorado, 80033-6005, United States
Local Institution - 012-562-B
Fleming Island, Florida, 32003, United States
Holy Cross Health Fort Lauderdale - Holy Cross Hospital
Fort Lauderdale, Florida, 33308, United States
21st Century Oncology of Jacksonville - North Lee Street
Jacksonville, Florida, 32204, United States
Local Institution - 012-562-D
Jacksonville, Florida, 32204, United States
Local Institution - 012-562-E
Jacksonville, Florida, 32207, United States
Local Institution - 012-562-A
Jacksonville, Florida, 32256, United States
Local Institution - 012-562-C
Jacksonville, Florida, 32256, United States
Local Institution - 012-562-F
Jacksonville, Florida, 32256, United States
Local Institution - 012-562-G
Jacksonville, Florida, 32256, United States
Local Institution - 012-562
Jacksonville, Florida, 32256, United States
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
Orlando Health University of Florida Health Cancer Center - Head and Neck Center
Orlando, Florida, 32806, United States
USOR - Woodlands Medical Specialists
Pensacola, Florida, 32503, United States
Local Institution - 012-839
Plantation, Florida, 33322, United States
University Cancer & Blood Center (UCBC) - Athens
Athens, Georgia, 30607, United States
Local Institution - 012-835 - A
Austell, Georgia, 30106, United States
Local Institution - 012-835 - B
Carrollton, Georgia, 30117, United States
Local Institution - 012-835 - C
Cartersville, Georgia, 30121, United States
Local Institution - 012-835 - D
Douglasville, Georgia, 30134, United States
Northwest Georgia Oncology Centers Wellstar - Marietta
Marietta, Georgia, 30060, United States
University of Illinois Hospital & Health Sciences System
Chicago, Illinois, 60612, United States
University of Chicago
Chicago, Illinois, 60637, United States
Local Institution - 012-972 C
Harvey, Illinois, 60426, United States
Local Institution - 012-972 A
New Lenox, Illinois, 60451, United States
Illinois Cancer Specialists - Niles
Niles, Illinois, 60714, United States
Local Institution - 012-972 B
Orland Park, Illinois, 60462, United States
Goshen Center for Cancer Care
Goshen, Indiana, 46526, United States
Local Institution - 012-569
Indianapolis, Indiana, 46237, United States
Local Institution - 012-569 - B
Lafayette, Indiana, 47905, United States
Local Institution - 012-569 - C
Lafayette, Indiana, 47905, United States
Local Institution - 012-569 - A
Mooresville, Indiana, 46158, United States
Franciscan Health Munster
Munster, Indiana, 46321, United States
Local Institution - 012-942-B
Chanute, Kansas, 66720, United States
Local Institution - 012-942-C
Dodge City, Kansas, 67801, United States
Local Institution - 012-942-D
El Dorado, Kansas, 67042, United States
Local Institution - 012-942-E
Independence, Kansas, 67301, United States
Local Institution - 012-942-F
Kingman, Kansas, 67068, United States
Local Institution - 012-942-G
Liberal, Kansas, 67901, United States
Local Institution - 012-942-H
McPherson, Kansas, 67460, United States
Local Institution - 012-942-I
Newton, Kansas, 67114, United States
Local Institution - 012-942-J
Parsons, Kansas, 67357, United States
Local Institution - 012-942-K
Pratt, Kansas, 67124, United States
Local Institution - 012-942-L
Salina, Kansas, 67401, United States
Local Institution - 012-942-M
Wellington, Kansas, 67152, United States
Local Institution - 012-820
Westwood, Kansas, 66205, United States
Local Institution - 012-942-A
Wichita, Kansas, 67208, United States
Local Institution - 012-942
Wichita, Kansas, 67214, United States
Local Institution - 012-942-N
Winfield, Kansas, 67156, United States
Baptist Health Lexington
Lexington, Kentucky, 40503, United States
Local Institution - 012-911 A
New Orleans, Louisiana, 70112, United States
Tulane University
New Orleans, Louisiana, 70112, United States
Local Institution - 012-954 - A
Kennebunk, Maine, 04043, United States
New England Cancer Specialists - Scarborough
Scarborough, Maine, 04074, United States
Local Institution - 012-954 - B
Topsham, Maine, 04086, United States
Frederick Health
Frederick, Maryland, 21702, United States
Local Institution - 012-974-B
Novi, Michigan, 48374, United States
Local Institution - 012-974-C
Novi, Michigan, 48374, United States
Ascension Providence Cancer Center - Southfield
Southfield, Michigan, 48075, United States
Local Institution - 012-974-A
Southfield, Michigan, 48075, United States
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613, United States
Local Institution - 012-841 - A
Billings, Montana, 59101, United States
St. Vincent Healthcare Cancer Centers of Montana
Billings, Montana, 59101, United States
Sisters of Charity of Leavenworth Health St. Marys
Billings, Montana, 59102, United States
Astera Cancer Care - East Brunswick
East Brunswick, New Jersey, 08816, United States
Local Institution - 012-975 - A
Edison, New Jersey, 08820, United States
Local Institution - 012-975 - B
Monroe, New Jersey, 08831, United States
Local Institution - 012-975 - C
Somerset, New Jersey, 08873, United States
Local Institution - 012-975 - D
Somerville, New Jersey, 08876, United States
Holy Name Medical Center
Teaneck, New Jersey, 07666, United States
SUNY Upstate Medical University
Syracuse, New York, 13210-2306, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
Kettering Health Cancer Center - Main Campus
Kettering, Ohio, 45429, United States
Oregon Oncology Specialists
Salem, Oregon, 97301, United States
Lifespan Cancer Institute - Rhode Island Hospital
Providence, Rhode Island, 02903, United States
Local Institution - 012-960-A
Providence, Rhode Island, 02906, United States
Prisma Health Cancer Institute - Faris Road
Greenville, South Carolina, 29605, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
Texas Oncology - Dallas Fort Worth (DFW) - Arlington Cancer Center North
Arlington, Texas, 76012, United States
Texas Oncology - Dallas Fort Worth (DFW) - South Austin
Austin, Texas, 78745, United States
US Oncology Research (USOR)
Irving, Texas, 75063, United States
Texas Oncology - Sherman
Sherman, Texas, 75090, United States
Utah Cancer Specialists - UCS Cancer Center
Salt Lake City, Utah, 84106, United States
Local Institution - 012-976-A
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-B
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-C
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-D
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-E
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-F
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-G
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-H
Salt Lake City, Utah, 84124, United States
Local Institution - 012-976-I
Salt Lake City, Utah, 84124, United States
Local Institution - 012-814 - B
Arlington, Virginia, 22205, United States
UVA Health - University Hospital
Charlottesville, Virginia, 22908-0674, United States
Local Institution - 012-814 - A
Fairfax, Virginia, 22031, United States
NEXT Virginia
Fairfax, Virginia, 22031, United States
Local Institution - 012-814 - C
Gainesville, Virginia, 20155, United States
Local Institution - 012-814 - D
Leesburg, Virginia, 20176, United States
Local Institution - 012-016
Mackay, Queensland, 4740, Australia
Local Institution - 012-005
Bedford Park, 5042, Australia
Local Institution - 012-004
Clayton, 3168, Australia
Townsville University Hospital
Douglas, 4814, Australia
Local Institution - 012-013
St Leonards, 2065, Australia
Local Institution - 012-019
Tweed Heads, 2485, Australia
Cancer Care Wollongong
Wollongong, 2500, Australia
Princess Alexandra Hospital
Woolloongabba, 4102, Australia
Klinikum Klagenfurt Am Worthersee
Klagenfurt, 9020, Austria
Uniklinikum Salzburg
Salzburg, 5020, Austria
Wiener Gesundheitsverbund - Klinik Ottakring
Vienna, 1160, Austria
Universitair Ziekenhuis Brussel
Brussels, 1090, Belgium
Local Institution - 012-157
Edegem, 2650, Belgium
Local Institution - 012-155
Ghent, 9000, Belgium
Local Institution - 012-151
Gilly, 6060, Belgium
Local Institution - 012-158
Hasselt, 3500, Belgium
Local Institution - 012-152
Roeselare, 8800, Belgium
Algemeen Ziekenhuis Glorieux Ronse
Ronse, 9600, Belgium
Local Institution - 012-150
Yvoir, B-5530, Belgium
Local Institution - 012-164
Hořovice, 268 31, Czechia
Local Institution - 012-162
Olomouc, 779 00, Czechia
Vseobecna Fakultni Nemocnice v Praze
Prague, 128 08, Czechia
Fakultni nemocnice Bulovka
Praha 8 - Liben, 180 81, Czechia
Local Institution - 012-191-A
Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France
Local Institution - 012-191-B
Lyon, Rhone, 69004, France
Local Institution - 012-194
Brest, 29200, France
Hopital Louis Pradel
Bron, 69500, France
Local Institution - 012-193
Caen, 14033, France
Local Institution - 012-196
Caen, 14076, France
Centre Hospitalier Intercommunal de Creteil
Créteil, 94000, France
Local Institution - 012-192
Dijon, 21079, France
LHopital Nord-Ouest (HNO) - Villefranche-sur-Saone
Gleizé, 69400, France
Hopital Michallon
La Tronche, 38700, France
Centre Hospitalier Regional Universitaire de Lille
Lille, 59037, France
Centre Hospitalier Universitaire Dupuytren 1
Limoges, 87042, France
Institut Paoli-Calmettes
Marseille, 13009, France
Hopital Nord de Marseille
Marseille, 13015, France
Hopital Arnaud de Villeneuve
Montpellier, 34090, France
Hopital Emile Muller
Mulhouse, 68100, France
Local Institution - 012-685
Nice, 06189, France
Centre Hospitalier de Cornouaille - Hopital Laennec
Quimper, 29107, France
Institut de Cancerologie de lOuest - Saint-Herblain - Site Rene Gauducheau
Saint-Herblain, 44805, France
Hopital Civil
Strasbourg, 67091, France
Local Institution - 012-197
Strasbourg, 67200, France
Hopital Bretonneau
Tours, 37044, France
Gustave Roussy
Villejuif, 94805, France
Local Institution - 012-219
Bad Berka, 99437, Germany
Universitatsklinikum Bonn
Bonn, 53127, Germany
Klinikum Koln-Merheim
Cologne, 51109, Germany
Local Institution - 012-210
Essen, 45136, Germany
Local Institution - 012-214
Gauting, 82131, Germany
Local Institution - 012-671
Giessen, 35392, Germany
LungenClinic Grosshansdorf
Grohansdorf, 22927, Germany
Local Institution - 012-215
Halle, 06120, Germany
Universitatsklinikum Jena
Jena, 07747, Germany
Klinikum Kassel
Kassel, 34125, Germany
Local Institution - 012-224
Löwenstein, 74245, Germany
Local Institution - 012-216
Lübeck, 23538, Germany
Local Institution - 012-220
München, 81925, Germany
Local Institution - 012-672
Offenbach, 63069, Germany
Pius-Hospital Oldenburg
Oldenburg, 26121, Germany
Henry Dunant Hospital Center
Athens, Attica, 11526, Greece
Local Institution - 012-236
Athens, 11527, Greece
University General Hospital of Heraklion (PAGNI)
Heraklion, 71110, Greece
Local Institution - 012-235
Larissa, 41110, Greece
"General Oncology Hospital of Kifisias "Agioi Anargyroi""
Nea Kifissia, 145 64, Greece
Local Institution - 012-234
Piraeus, 185 47, Greece
Metropolitan Hospital
Piraeus, 185 47, Greece
BioClinic Thessaloniki
Thessaloniki, 54622, Greece
Local Institution - 012-230
Thessaloniki, 57001, Greece
Local Institution - 012-500
Thessaloniki, 57010, Greece
Anassa General Clinic
Volos, 38333, Greece
Humanity & Health Clinical Trial Centre
Central, 0, Hong Kong
Prince of Wales Hospital - Hong Kong
Hong Kong, 0, Hong Kong
Hong Kong United Oncology Centre
Kowloon, 0, Hong Kong
Local Institution - 012-242
Budapest, 1083, Hungary
Local Institution - 012-244
Budapest, 1121, Hungary
Local Institution - 012-241
Budapest, 1122, Hungary
Local Institution - 012-243
Gyöngyös, 3200, Hungary
Local Institution - 012-763
Gyula, 5700, Hungary
Local Institution - 012-759
Székesfehérvár, 8000, Hungary
Reformatus Pulmonologiai Centrum
Törökbálint, 2045, Hungary
The Meath Foundation
Tallaght, Dublin, D24 NR04, Ireland
St. Vincents University Hospital
Dublin, 4, Ireland
Beaumont Hospital - Dublin
Dublin, 9, Ireland
St. Jamess Hospital
Dublin, D08 NHY1, Ireland
University Hospital Galway
Galway, H91 YR71, Ireland
University Hospital Limerick
Limerick, V94 F858, Ireland
Local Institution - 012-276
Alessandria, 15121, Italy
Local Institution - 012-292
Avellino, 83100, Italy
Local Institution - 012-274
Aviano, 33081, Italy
Local Institution - 012-275
Bari, 70124, Italy
Local Institution - 012-765
Brescia, 25123, Italy
Local Institution - 012-286
Candiolo, 10060, Italy
Local Institution - 012-284
Catania, 95122, Italy
Local Institution - 012-282
Catania, 95123, Italy
Local Institution - 012-762
Florence, 50134, Italy
Local Institution - 012-273
Genova, 16100, Italy
Local Institution - 012-285
Genova, 16132, Italy
Local Institution - 012-279
Lecce, 73100, Italy
"Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST"
Meldola, 47014, Italy
Local Institution - 012-296
Milan, 20132, Italy
Local Institution - 012-278
Milan, 20141, Italy
Local Institution - 012-283
Milan, 20133, Italy
Local Institution - 012-271
Napoli, 80131, Italy
Local Institution - 012-277
Napoli, 80131, Italy
Local Institution - 012-770
Novara, 28100, Italy
Local Institution - 012-272
Parma, 43126, Italy
Local Institution - 012-281
Perugia, 06132, Italy
Local Institution - 012-766
Pesaro, 61122, Italy
Local Institution - 012-767
Ravenna, 48121, Italy
Local Institution - 012-295
Roma, 00144, Italy
Local Institution - 012-758
Verona, 37126, Italy
Local Institution - 012-306
Amsterdam, 1081 HV, Netherlands
Amphia Ziekenhuis - Breda Molengracht
Breda, 4818 CK, Netherlands
Local Institution - 012-300
Maastricht, 6229 HX, Netherlands
Local Institution - 012-630
Nijmegen, 6525 GA, Netherlands
Local Institution - 012-308
The Hague, 2545 AA, Netherlands
Local Institution - 012-307
Utrecht, 3543 AZ, Netherlands
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
Instytut MSF
Lodz, 90-302, Poland
Local Institution - 012-321
Lublin, 20-064, Poland
Local Institution - 012-760
Lublin, 20-093, Poland
Local Institution - 012-325
Otwock, 05-400, Poland
Local Institution - 012-320
Rzeszów, 35-922, Poland
Local Institution - 012-324
Skorzewo, 60-185, Poland
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu
Torun, 87-100, Poland
Local Institution - 012-322
Warsaw, 02-781, Poland
Wojskowy Instytut Medyczny
Warsaw, 04-349, Poland
Unidade Local de Saude de Almada-Seixal, E. P. E (Hospital Garcia de Orta)
Almada, 2805-267, Portugal
Unidade Local de Saude de Braga, E. P. E (Hospital de Braga)
Braga, 4710-243, Portugal
Local Institution - 012-330
Coimbra, 3000-075, Portugal
Local Institution - 012-645
Coimbra, 3000-075, Portugal
Local Institution - 012-333
Guimarães, 4835-044, Portugal
Local Institution - 012-642
Lisbon, 1099-023, Portugal
Local Institution - 012-338-A
Lisbon, 1350-352, Portugal
The Champalimaud Centre for the Unknown
Lisbon, 1400-038, Portugal
Local Institution - 012-338
Lisbon, 1998-018, Portugal
Unidade Local de Saude de Loures-Odivelas, EPE (Hospital Beatriz Angelo)
Loures, 2674-514, Portugal
Hospital CUF Porto
Porto, 14341, Portugal
Local Institution - 012-331
Porto, 4099-001, Portugal
Local Institution - 012-339
Porto, 4200-072, Portugal
Unidade Local de Saude de Entre Douro e Vouga, E. P. E
Santa Maria da Feira, 4520-211, Portugal
Unidade Local de Saude da Arrabida, E. P. E (Centro Hospitalar de Setubal)
Setúbal, 2910-443, Portugal
Unidade Local de Saude de Gaia/Espinho, E. P. E
Vila Nova de Gaia, 4434-502, Portugal
Puerto Rico Medical Research Center
San Juan, 00919, Puerto Rico
FDI Clinical Research (Fundacion de Investigacion de Diego) - San Juan
San Juan, 00927, Puerto Rico
PanOncology Trials - Rio Piedras Medical Center
San Juan, 00935, Puerto Rico
Spitalul Jude�ean de Urgen�a dr. Constantin Opri� Baia Mare
Baia Mare, 430031, Romania
SC Policlinica de Diagnostic Rapid SA
Brasov, 500152, Romania
Centrul Oncologic Sanador
Bucharest, 010991, Romania
Local Institution - 012-342
Bucharest, 022328, Romania
Local Institution - 012-344
Cluj-Napoca, 400015, Romania
Local Institution - 012-340
Cluj-Napoca, 400641, Romania
Oncolab Craiova
Craiova, 200385, Romania
Local Institution - 012-343
Craiova, 200746, Romania
Local Institution - 012-513
Iași, 700106, Romania
Ovidius Clinical Hospital
Ovidiu, 905900, Romania
Oncocenter - Oncologie Clinica
Timișoara, 300166, Romania
SC OncoMed SRL
Timișoara, 300239, Romania
Evimed Oncology Clinic
Chelyabinsk, 454048, Russia
"Budgetary Healthcare Institution of the Udmurt Republic "Republican Clinical Oncological Dispensary n.a. Sergey Grigoryevich Pr
Izhevsk, 426067, Russia
"Regional Budgetary Healthcare Institution "G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center" of the Healthcare C
Kislino Village, 305524, Russia
VitaMed - Moscow
Moscow, 121309, Russia
University Headache Clinic
Moscow, 121467, Russia
State Budgetary Healthcare Institution of the Nizhny Novgorod Region Clinical Diagnostic Center
Nizhny Novgorod, 603006, Russia
"Limited Liability Company Medical Sanitary Unit "Clinicist-Clinic Pretor""
Novosibirsk, 630099, Russia
"Budgetary Healthcare Institution of Omsk region "Clinical Oncologic Dispensary""
Omsk, 644013, Russia
Local Institution - 012-355
Saint Petersburg, 197022, Russia
"Federal State Budgetary Institution "Influenza Research Institute named after N.N. A.A. Smorodintsev" of the Ministry of Health
Saint Petersburg, 197376, Russia
Local Institution - 012-354
Saint Petersburg, 197758, Russia
Local Institution - 012-093
Singapore, 168583, Singapore
Raffles Hospital
Singapore, 188770, Singapore
Icon Cancer Centre Farrer Park
Singapore, 217562, Singapore
Oncocare Cancer Centre
Singapore, 258499, Singapore
Parkway Cancer Centre - Gleneagles Hospital
Singapore, 258500, Singapore
Local Institution - 012-111
Busan, 48108, South Korea
Local Institution - 012-522
Busan, 49241, South Korea
Local Institution - 012-101
Busan, 602702, South Korea
Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
Local Institution - 012-110
Daegu, 41404, South Korea
Local Institution - 012-523
Daegu, 42601, South Korea
Local Institution - 012-100
Hwasun-gun, 58128, South Korea
Local Institution - 012-103
Incheon, 21565, South Korea
Local Institution - 012-102
Junggu, 400-712, South Korea
Local Institution - 012-520
Seongnam-si, 13496, South Korea
Local Institution - 012-112
Seongnam-si, 13620, South Korea
Korea University Anam Hospital
Seoul, 02841, South Korea
Local Institution - 012-118
Seoul, 03722, South Korea
Local Institution - 012-106
Seoul, 05080, South Korea
Asan Medical Center
Seoul, 05505, South Korea
The Catholic University of Korea - Seoul St. Marys Hospital
Seoul, 06591, South Korea
Catholic University of Korea St. Vincents Hospital
Suwon, 16247, South Korea
Local Institution - 012-107
Suwon, 16499, South Korea
Clinica Universidad de Navarra - Pamplona
Pamplona, Navarre, 31008, Spain
Local Institution - 012-613
A Coruña, 15006, Spain
Local Institution - 012-769
Alicante, 3010, Spain
Hospital Germans Trias i Pujol
Badalona, 08916, Spain
Local Institution - 012-776
Barakaldo, 48903, Spain
Hospital del Mar - Parc de Salut Mar
Barcelona, 08003, Spain
Local Institution - 012-614
Barcelona, 08028, Spain
Local Institution - 012-612
Barcelona, 08035, Spain
Local Institution - 012-600
Barcelona, 08036, Spain
Local Institution - 012-621
Córdoba, 14004, Spain
Local Institution - 012-764
Girona, 17007, Spain
Local Institution - 012-616
Granada, 18014, Spain
Complejo Hospitalario Universitario Insular Materno Infantil
Las Palmas de Gran Canaria, 35016, Spain
Hospital de Leon
León, 24071, Spain
Local Institution - 012-615
Lugo, 27003, Spain
Local Institution - 012-607
Madrid, 28007, Spain
Clinica Universidad de Navarra - Madrid
Madrid, 28027, Spain
Local Institution - 012-606
Madrid, 28034, Spain
Local Institution - 012-601
Madrid, 28040, Spain
Local Institution - 012-609
Madrid, 28040, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Local Institution - 012-626
Majadahonda, 28222, Spain
Local Institution - 012-608
Málaga, 29009, Spain
Local Institution - 012-602
Palma de Mallorca, 07120, Spain
Local Institution - 012-604
Santander, 39008, Spain
Local Institution - 012-629
Seville, 41013, Spain
Consorci Hospital General Universitari de Valencia
Valencia, 46014, Spain
Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
Local Institution - 012-603
Zaragoza, 50009, Spain
Universitatsspital Basel
Basel, 4031, Switzerland
Spital Simmental-Thun-Saanenland
Thun, 3604, Switzerland
Kantonsspital Winterthur
Winterthur, 8401, Switzerland
University Hospitals Birmingham NHS Foundation Trust
Birmingham, B9 5SS, United Kingdom
NHS Lothian
Edinburgh, EH4 2XU, United Kingdom
NHS Greater Glasgow and Clyde
Glasgow, G12 0XH, United Kingdom
University Hospitals of Leicester NHS Trust
Leicester, LE1 5WW, United Kingdom
The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
Related Publications (1)
Barlesi F, Yao W, Duruisseaux M, Doucet L, Martinez AA, Gregorc V, Juan-Vidal O, Lu S, De Bondt C, de Marinis F, Linardou H, Kim YC, Jotte R, Felip E, Lo Russo G, Reck M, Michenzie MF, Yang W, Meade JN, Korytowsky B, Mok TSK; KRYSTAL-12 Investigators. Adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer (KRYSTAL-12): a randomised, open-label, phase 3 trial. Lancet. 2025 Aug 9;406(10503):615-626. doi: 10.1016/S0140-6736(25)00866-9.
PMID: 40783289DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Bristol-Myers Squibb Study Director
- Organization
- Bristol-Myers Squibb
Study Officials
- STUDY DIRECTOR
Bristol-Myers Squibb
Bristol-Myers Squibb
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
- Expanded Access
- Yes
Study Record Dates
First Submitted
December 21, 2020
First Posted
December 28, 2020
Study Start
February 23, 2021
Primary Completion
December 30, 2023
Study Completion (Estimated)
July 2, 2026
Last Updated
January 22, 2025
Results First Posted
January 22, 2025
Record last verified: 2025-01
Data Sharing
- IPD Sharing
- Will not share