PATHWEIGH: Pragmatic Weight Management in Primary Care
2 other identifiers
interventional
100,000
1 country
64
Brief Summary
The study examines patient weight loss and maintenance, associated predictors (patient health characteristics and demographics), and contextual factors in the practice environment that influence the intervention's adoption, implementation, and sustainability. This will be achieved through a mixed methods implementation study including collection and analysis of de-identified clinical data, surveys, observations, and interviews.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable obesity
Started Mar 2020
Longer than P75 for not_applicable obesity
64 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 17, 2020
CompletedFirst Submitted
Initial submission to the registry
November 24, 2020
CompletedFirst Posted
Study publicly available on registry
December 22, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 16, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2025
CompletedMay 30, 2025
April 1, 2025
4.5 years
November 24, 2020
May 23, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Patient weight trajectories over the 6 months after the initial weight measured in the usual care and intervention phases
Change in patient weight trajectories 0-6 months after the initial weight measurement in the usual care and intervention phases.
0 to 6 months
Patient weight maintenance, as measured by patient weight trajectories from 6 to 18 months after the initial weight measurement, in the usual care and intervention phases
Change in patient weight trajectories from 6 to 18 months after the initial weight measurement in the usual care and intervention phases.
6 to 18 months
Secondary Outcomes (1)
Patient weight maintenance, as measured by patient weight trajectories from 6 to 18 months after the initial weight measurement, in the usual care and intervention phases stratified by those received vs. did not receive discernible weight-related care
6 to 18 months
Other Outcomes (8)
Reach - The representativeness of individuals who participate in the trial.
Baseline and each 1 year step after
Qualitative assessment of the reach of patient recruitment
6 months post intervention start
Adoption - The representativeness of providers who initiate the intervention
Baseline and at each 1 year step
- +5 more other outcomes
Study Arms (2)
Standard of Care
ACTIVE COMPARATOREach primary care provider will administer weight loss care per their standard practice.
PATHWEIGH
EXPERIMENTALA weight management care path that support primary care both through the EHR and training for the clinicians.
Interventions
* Documentation and data capture built in the Electronic Health Record * Clinical data support that suggests weight loss approach(es) * Tracking of weight loss progress and weight loss maintenance during patient visits to guide the patient-clinician conversation * Diagnosis and billing in EHR automatically adds the diagnosis of overweight or obesity and links the most common weight-related co-morbidities to ensure adequate provider reimbursement * Evidence-based online training on weight management for clinicians * Practice quality improvement and training for use of PATHWEIGH for weight-prioritized visits through practice coaches/facilitators * Consultation support by practice facilitators with implementing PATHWEIGH and by obesity providers for clinicians with creating patient treatment plans
Within primary care the option to select "Obesity brief HPI", this is a brief historical intake of a patient's weight - when either they or their clinician decides to have a weight-prioritized visit. It is intended to initiate a discussion regarding potential strategies for weight loss (often "eat less, exercise more"). The provider has the discretion to augment or add support as they see fit.
Eligibility Criteria
You may qualify if:
- Affiliated with a participating primary care practice
- Provide care for adult patients (\>=18 years old)
- All adult patients (age \>18 years)
- BMI \>25 kg/m2
- Appointment at a primary care clinic participating in the study
You may not qualify if:
- Unable to participate in weight loss treatment due to factors such as cognitive deficits, non-home residence, or limited life expectancy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (64)
UCHealth Primary Care - Arvada West
Arvada, Colorado, 80007, United States
UCHealth Primary Care - Quincy
Aurora, Colorado, 80015, United States
UCHealth Executive Health Services - Anschutz Medical Campus
Aurora, Colorado, 80045, United States
UCHealth Internal Medicine - Anschutz Medical Campus
Aurora, Colorado, 80045, United States
UCHealth Seniors Clinic - Anschutz Medical Campus
Aurora, Colorado, 80045, United States
UCHealth Women's Integrated Services in Health - Anschutz Medical Campus
Aurora, Colorado, 80045, United States
UCHealth Family Medicine - Boulder
Boulder, Colorado, 80303, United States
UCHealth CU Family Medicine - Depot Hill
Broomfield, Colorado, 80020, United States
UCHealth Primary Care - Broomfield
Broomfield, Colorado, 80020, United States
UCHealth Primary Care - Castle Rock
Castle Rock, Colorado, 80104, United States
UCHealth CU Family Medicine - Centennial
Centennial, Colorado, 80122, United States
UCHealth Primary Care and Sports Medicine Clinic - Lake Plaza
Colorado Springs, Colorado, 80906, United States
UCHealth Primary Care - Fontanero
Colorado Springs, Colorado, 80907, United States
UCHealth Internal Medicine - Printers Park
Colorado Springs, Colorado, 80910, United States
UCHealth Sports Medicine Clinic - Printers Park
Colorado Springs, Colorado, 80910, United States
UCHealth Primary Care - Academy
Colorado Springs, Colorado, 80918, United States
UCHealth Primary Care - Rockrimmon
Colorado Springs, Colorado, 80919, United States
UCHealth Aspen Creek Medical Center
Colorado Springs, Colorado, 80920, United States
UCHealth Primary Care - Briargate
Colorado Springs, Colorado, 80920, United States
UCHealth Primary Care - Chapel Hills
Colorado Springs, Colorado, 80920, United States
UCHealth Primary Care - Scarborough
Colorado Springs, Colorado, 80920, United States
UCHealth Primary Care - Craig
Craig, Colorado, 81625, United States
UCHealth Primary Care - Cripple Creek
Cripple Creek, Colorado, 80813, United States
UCHealth Primary Care - Steele Street
Denver, Colorado, 80206, United States
UCHealth CU Internal Medicine - Garfield
Denver, Colorado, 80209, United States
UCHealth Primary Care - Uptown
Denver, Colorado, 80218, United States
UCHealth Internal Medicine - Lowry
Denver, Colorado, 80230, United States
UCHealth A.F. Williams Family Medicine Clinic - Central Park
Denver, Colorado, 80238, United States
UCHealth Primary Care - Estes Park
Estes Park, Colorado, 80517, United States
UCHealth Primary Care - Falcon
Falcon, Colorado, 80831, United States
UCHealth Family Medicine - Firestone
Firestone, Colorado, 80504, United States
UCHealth Family Medicine Center - Fort Collins
Fort Collins, Colorado, 80524, United States
UCHealth Internal Medicine - Prospect
Fort Collins, Colorado, 80525, United States
UCHealth Internal Medicine - Snow Mesa
Fort Collins, Colorado, 80528, United States
UCHealth Internal Medicine and Pediatric Care Clinic - Snow Mesa
Fort Collins, Colorado, 80528, United States
UCHealth Internal Medicine - Greeley Midtown
Greeley, Colorado, 80538, United States
UCHealth Family Medicine - Greeley
Greeley, Colorado, 80634, United States
UCHealth Internal Medicine - Greeley
Greeley, Colorado, 80634, United States
UCHealth CU Family Medicine - Landmark
Greenwood Village, Colorado, 80111, United States
UCHealth Primary Care - Greenwood Village
Greenwood Village, Colorado, 80111, United States
UCHealth Primary Care - Highlands Ranch
Highlands Ranch, Colorado, 80126, United States
UCHealth Family Medicine - Littleton
Highlands Ranch, Colorado, 80129, United States
UCHealth Primary Care - Sterling Ranch
Littleton, Colorado, 80125, United States
UCHealth Primary Care - Lone Tree
Lone Tree, Colorado, 80124, United States
UCHealth Primary Care - Yosemite
Lone Tree, Colorado, 80124, United States
UCHealth Women's Integrated Services in Health - Lone Tree
Lone Tree, Colorado, 80124, United States
UCHealth Family Medicine - Longmont
Longmont, Colorado, 80501, United States
UCHealth Internal Medicine - Longmont
Longmont, Colorado, 80501, United States
UCHealth Longmont Clinic
Longmont, Colorado, 80501, United States
UCHealth Orchards Medical Center
Loveland, Colorado, 80537, United States
UCHealth Family Medicine - North Loveland
Loveland, Colorado, 80538, United States
UCHealth Internal Medicine - East Loveland
Loveland, Colorado, 80538, United States
UCHealth Internal Medicine - Orchards
Loveland, Colorado, 80538, United States
UCHealth Primary Care - Monument
Monument, Colorado, 80132, United States
UCHealth Primary Care - Hilltop
Parker, Colorado, 80134, United States
UCHealth Primary Care and Women's Wellness - Stonegate
Parker, Colorado, 80134, United States
UCHealth Primary Care - Sterling
Sterling, Colorado, 80751, United States
UCHealth Primary Care - Timnath
Timnath, Colorado, 80547, United States
UCHealth Family Medicine - Westminster
Westminster, Colorado, 80021, United States
UCHealth Family Medicine - Windsor
Windsor, Colorado, 80550, United States
UCHealth Family Medicine - Woodland Park
Woodland Park, Colorado, 80863, United States
Little Snake River Clinic - Managed by UCHealth Yampa Valley Medical Center
Baggs, Wyoming, 82321, United States
UCHealth Cheyenne Medical Specialists
Cheyenne, Wyoming, 82009, United States
UCHealth Primary Care - Cheyenne
Cheyenne, Wyoming, 82009, United States
Related Publications (3)
Perreault L, Pan Q, Rodriguez C, Gritz RM, Smith PC, Kramer ES, Tolle L, Connelly L, Tietbohl C, Williams J 2nd, Holtrop JS. Implementation and effectiveness of a care process to prioritize weight management in primary care: a stepped-wedge cluster-randomized trial. Nat Med. 2025 Dec 11. doi: 10.1038/s41591-025-04051-5. Online ahead of print.
PMID: 41381746DERIVEDPerreault L, Suresh K, Rodriguez C, Dickinson LM, Willems E, Smith PC, Williams J Jr, Gritz RM, Holtrop JS. Baseline Characteristics of PATHWEIGH: A Stepped-Wedge Cluster Randomized Study for Weight Management in Primary Care. Ann Fam Med. 2023 May-Jun;21(3):249-255. doi: 10.1370/afm.2966.
PMID: 37217322DERIVEDSuresh K, Holtrop JS, Dickinson LM, Willems E, Smith PC, Gritz RM, Perreault L. PATHWEIGH, pragmatic weight management in adult patients in primary care in Colorado, USA: study protocol for a stepped wedge cluster randomized trial. Trials. 2022 Jan 10;23(1):26. doi: 10.1186/s13063-021-05954-7.
PMID: 35012628DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Leigh Perreault, MD
University of Colorado, Denver
- PRINCIPAL INVESTIGATOR
Jodi S Holtrop, PhD
University of Colorado, Denver
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 24, 2020
First Posted
December 22, 2020
Study Start
March 17, 2020
Primary Completion
September 16, 2024
Study Completion
July 31, 2025
Last Updated
May 30, 2025
Record last verified: 2025-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
Data sharing from 1R18DK127003 will comply with policies from the NIH https://grants.nih.gov/grants/policy/data\_sharing/), ICMJE (http://www.icmje.org/recommendations/browse/publishing-and-editorial-issues/clinical-trial-registration.html#two), as well as our IRB. No individual participant data will be shared. Data that will be publicly available (through their publication) will include study protocol, analysis plan, and results presented in aggregate. Additional information may be shared upon request.