Home-Based Telerehabilitation for People With Alzheimer Disease

NCT04606251 | Completed

• 1 other identifier: Kübra Nur Menengiç, IUC
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the effect of a physical exercise program with cognitive tasks to be applied with telerehabilitation in Alzheimer's disease, on cognitive and physical function, ability to perform daily living activities, depression and anxiety. Secondary aim is to examine the effect of the exercise application on the care burden and well-being of caregivers.

Conditions

Alzheimer Disease

Keywords

Exercise Training; Cognition; Telemedicine; Telehealth

Outcome Measures

Primary Outcomes (3)

• Cognitive Function-Mini Mental Test

  Mini Mental Test evaluates the cognitive skills. For each question of the test, the correct answer is scored as 1 point, the incorrect answer 0 point. Test is divided into two sections, the first of which requires vocal responses only and covers orientation, memory, and attention; the maximum score is 21. The second part tests ability to name, follow verbal and written commands, write a sentence spontaneously, and copy a complex polygon; the maximum score is 9.

  6 weeks

• Timed Up and Go Test

  Timed Up and Go Test measure the level of functional mobility skills and, assess fall risk and balance. The time elapsed between standing up from the sitting position, walking the distance of 3 meters, coming back and sitting back on the chair is recorded. The shorter time reflect the better performance.

  6 weeks

• Physical Mobility-5 Time Sit to Stand Test

  5 Time Sit to Stand Test measure the level of functional mobility skills and, assess fall risk and lower extremity strength. The test measures the time taken to stand five times from a sitting position as quickly as possible. The shorter time reflect the better performance.

  6 weeks

Secondary Outcomes (6)

• Balance-One Leg Stance Test

  6 weeks

• Activities of Daily Living-Katz Activities of Daily Living Scale

  6 weeks

• Depression-Geriatric Depression Scale

  6 weeks

• Anxiety-Beck Anxiety Inventory

  6 weeks

• Burden-Zarit Burden Scale

  6 weeks

Study Arms (2)

Arm 1: Exercise Group

EXPERIMENTAL

This group will consist of the subjects taken for 6 weeks of exercise.

Other: Exercise

Arm 2: Control Group

NO INTERVENTION

This group will consist of the subjects who did not receive any intervention for 6 weeks and were evaluated before and after 6 weeks.

Interventions

Exercise OTHER

The intervention to be carried out in the study consists of physical exercises for the neck, upper and lower extremities, and trunk; It is a program that includes the addition of cognitive tasks such as memory, word finding, processing during each repetition.

Arm 1: Exercise Group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Over 65 years old,
• Diagnosed with Alzheimer's disease according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease (NINCDS-ADRDA) criteria,
• Scoring between 0-2 points according to the Clinical Dementia Rating Scale (with mild-moderate dementia-related symptoms),
• Have used any dementia medication such as cholinesterase inhibitors and memantine for at least the last month,
• Mini Mental Test score between 13-24 points,
• The caregiver living with is sufficient in the use of technology,
• Cases who could understand the instructions given in Turkish were included in the study.

You may not qualify if:

• Dementia with Lewy bodies, frontotemporal dementia and one of the other types of dementia,
• Having a pulmonary, neurological, musculoskeletal or rheumatological disease that may prevent exercise,
• Unstable medical condition (uncontrolled diabetes or hypertension, deep vein thrombosis, etc.),
• Modified Charlson Comorbidity Index score greater than 6,
• Receiving any rehabilitation service from an institution or person,
• Having regular exercise habits,
• Subjects with visual or auditory deficits or behavioral problems that would make communication difficult were not included in the study.

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Istanbul University-Cerrahpasa

Istanbul, Turkey (Türkiye)

Location

Related Publications (1)

• Menengic KN, Yeldan I, Cinar N, Sahiner TA. Effectiveness of home-based telerehabilitation in mild to moderate Alzheimer's disease: A randomised controlled study. Alzheimers Dement. 2021 Dec;17 Suppl 8:e053406. doi: 10.1002/alz.053406.

  PMID: 34971285 DERIVED

MeSH Terms

Conditions

Alzheimer Disease

Interventions

Exercise

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Controlled Research Study

Study Record Dates

• First Submitted: October 24, 2020
• First Posted: October 28, 2020
• Study Start: October 30, 2020
• Primary Completion: November 20, 2020
• Study Completion: April 15, 2021
• Last Updated: July 22, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)