The Effects of Losartan on Emotion Processing
Losartan Effects on the Emotion Processing in Humans
1 other identifier
interventional
90
1 country
1
Brief Summary
The aim of the study is to investigate the effect of losartan (50mg, single dose) on salience processing
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable healthy
Started Oct 2020
Typical duration for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 9, 2020
CompletedStudy Start
First participant enrolled
October 10, 2020
CompletedFirst Posted
Study publicly available on registry
October 28, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2022
CompletedOctober 28, 2020
October 1, 2020
1.2 years
October 9, 2020
October 21, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Neural activity as measured by BOLD fMRI during processing of emotional and novel stimuli
During the oddball paradigm a series of pictures will be presented in rapid succession. Some of the stimuli are oddballs, with respect to emotional content (highly threatening stimuli) or novelty (novel stimuli). Neural activity will be measured by functional magnetic resonance imaging (fMRI). The fMRI data will be examined using a Generalized Linear Model approach. The analysis will examine neural activity in terms of the blood oxygenation dependent (BOLD) response towards threatening and novel oddballs. Effects of treatment on the BOLD response towards threatening and novel oddballs will be examined by comparing the losartan- and placebo-treated subjects.
105 to 145 minutes after treatment administration
Secondary Outcomes (3)
Neural activity as measured by BOLD fMRI during processing of different categories of emotional and novel stimuli
105 to 145 minutes after treatment administration
Accuracy for target oddballs
105 to 145 minutes after treatment administration
Reaction times for target oddballs
105 to 145 minutes after treatment administration
Study Arms (2)
Losartan group
EXPERIMENTALPlacebo group
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Healthy subjects without past or current psychiatric or neurological disorders
You may not qualify if:
- history of head injury
- medical or psychiatric illness
- hypertension
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Electronic Science and Technology of China
Chengdu, Sichuan, 611731, China
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Benjamin Becker, PhD
University of Electronic Science and Technology of China
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 9, 2020
First Posted
October 28, 2020
Study Start
October 10, 2020
Primary Completion
December 31, 2021
Study Completion
March 31, 2022
Last Updated
October 28, 2020
Record last verified: 2020-10
Data Sharing
- IPD Sharing
- Will not share