Real-time fMRI Neurofeedback Training on the Anterior Insula Based on Interoceptive Processing

NCT05260749 | Completed

• 1 other identifier: UESTC-neuSCAN-85
• Study Type: interventional
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

The main aim of the study is to investigate whether subjects can learn self control of activity of the anterior insula via real-time functional magnetic resonance imaging (fMRI) neurofeedback training based on a regulation strategy of interoceptive processing.

Conditions

Healthy

Keywords

real-time neurofeedback; anterior insula; Interoceptive Processing

Outcome Measures

Primary Outcomes (1)

• Neural activity of the anterior insula based on blood oxygen level-dependent (BOLD) signal

  The anterior insula activity induced by neurofeedback training relative to sham feedback training

  1 hour

Secondary Outcomes (2)

• Confidence rating scores of interoceptive sensitivity

  1 hour

• pain empathy ratings scores

  1 hour

Study Arms (3)

Neurofeedback training

EXPERIMENTAL

Subjects in the neurofeedback training group are instructed to regulate their anterior insula activity based on the visual neurofeedback.

Procedure: real-time fMRI neurofeedback training procedure

Sham control1

SHAM COMPARATOR

Subjects in the sham control group receive the same instruction but perform the regulation based on neurofeedback from a whole slice of top brain (a controlled sham region).

Procedure: real-time fMRI sham-controlled neurofeedback training procedure

Sham control2

SHAM COMPARATOR

Subjects in the sham control group receive the same instruction but perform the regulation based on neurofeedback from the middle temporal gyrus (a controlled sham region).

Procedure: real-time fMRI sham-controlled neurofeedback training procedure

Interventions

real-time fMRI neurofeedback training procedure PROCEDURE

real-time fMRI neurofeedback training procedure running on the Turbo Brain voyager (TBV) 3.2 software (Brain Innovation, Maastricht, The Netherlands)

Neurofeedback training

real-time fMRI sham-controlled neurofeedback training procedure PROCEDURE

real-time fMRI sham neurofeedback training procedure running on the Turbo Brain voyager (TBV) 3.2 software (Brain Innovation, Maastricht, The Netherlands)

Sham control1; Sham control2

Eligibility Criteria

• Age: 18 Years - 28 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjects without any past or present psychiatric or neurological disorders

You may not qualify if:

• History of brain injury Medical or mental illness

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead

Study Sites (1)

University of Electronic Science and Technology of China(UESTC)

Chengdu, Sichuan, China

Location

Related Publications (1)

• Zhang Y, Zhang Q, Wang J, Zhou M, Qing Y, Zou H, Li J, Yang C, Becker B, Kendrick KM, Yao S. "Listen to your heart": A novel interoceptive strategy for real-time fMRI neurofeedback training of anterior insula activity. Neuroimage. 2023 Dec 15;284:120455. doi: 10.1016/j.neuroimage.2023.120455. Epub 2023 Nov 10.

  PMID: 37952779 DERIVED

Study Officials

• Yao Shuxia, Dr

  University of Electronic Science and Technology of China

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: February 8, 2022
• First Posted: March 2, 2022
• Study Start: June 16, 2021
• Primary Completion: November 15, 2022
• Study Completion: December 1, 2022
• Last Updated: December 14, 2022

Record last verified: 2022-12

Locations

CN (1)