The Effect of Modafinil on Affective and Cognitive Processing
The Effect of Modafinil on Neural Processing During the Interference and Feedback Based Learning Task
1 other identifier
interventional
60
1 country
1
Brief Summary
The study aims to examine whether a single dose of modafinil (200mg, p.o.) can affect feedback-based learning and interference processing in healthy male subjects.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable healthy
Started Jan 2018
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2018
CompletedFirst Submitted
Initial submission to the registry
February 1, 2018
CompletedFirst Posted
Study publicly available on registry
February 8, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2020
CompletedJune 17, 2019
June 1, 2019
2 years
February 1, 2018
June 14, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Neural processing during the interference processing
fMRI BOLD indices of neural processing in interference related brain regions will be compared between the treatment and placebo group.
4h after treatment
Neural processing during feedback based learning
fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment and placebo group.
4h after treatment
Secondary Outcomes (4)
Behavioral interference performance - Response Time
4h after treatment
Behavioral interference performance - Accuracy
4h after treatment
Behavioral learning performance - Reaction time
4h after treatment
Behavioral learning performance - Accuracy
4h after treatment
Study Arms (2)
modafinil group
EXPERIMENTALa single dose of p.o. modafinil (200mg)
placebo group
EXPERIMENTALa single dose of p.o. placebo (200mg)
Interventions
Eligibility Criteria
You may qualify if:
- Healthy subjects without past or current psychiatric or neurological disorders
- Non-smokers
- Right-handedness
You may not qualify if:
- Medical or psychiatric illness
- Allergy against medications or general strong allergies
- Sleep disorders
- High blood pressure, general cardio-vascular alterations
- History of head injury
- Visual or motor impairments
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
School of Life Science and Technology
Chengdu, Sichuan, 611731, China
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 1, 2018
First Posted
February 8, 2018
Study Start
January 1, 2018
Primary Completion
January 1, 2020
Study Completion
July 1, 2020
Last Updated
June 17, 2019
Record last verified: 2019-06
Data Sharing
- IPD Sharing
- Will not share