NCT04922684

Brief Summary

The main aim of the present study is to investigate whether mimicking emotional expressions training via FaceReader software can improve emotional processing and recognition in healthy subjects, especially individuals with hityer autistic traits.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
90

participants targeted

Target at P75+ for not_applicable healthy

Timeline
Completed

Started Mar 2020

Typical duration for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 30, 2020

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

May 14, 2021

Completed
28 days until next milestone

First Posted

Study publicly available on registry

June 11, 2021

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2021

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2022

Completed
Last Updated

June 11, 2021

Status Verified

June 1, 2021

Enrollment Period

1.8 years

First QC Date

May 14, 2021

Last Update Submit

June 3, 2021

Conditions

Keywords

Mimic facial expression trainingAutistic traitMirror neuron systemEmotion processingEmotion recognition

Outcome Measures

Primary Outcomes (4)

  • Intensity score of subjects' mimic facial emotions

    The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into intensity, ranging from 0 to 1.

    an average of 4 weeks

  • Valence score of subjects' mimic facial emotions

    The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into valence, ranging from -1 to 1.

    an average of 4 weeks

  • Arousal score of subjects' mimic facial emotions

    The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into arousal, ranging from 0 to 1.

    an average of 4 weeks

  • Task-dependent functional MRI data

    Neural activities of brain regions, notably mirror neuron system will be collected for analysis when the subjects participate in a face processing and emotion recognition task in a MRI scanner before and after the 4-week training session.

    an average of 4 weeks

Study Arms (2)

Lower austic sub-group

ACTIVE COMPARATOR

16 times of mimicking emotional expressions

Behavioral: Mimic facial expressions

Higher austic sub-group

EXPERIMENTAL

16 times of mimicking emotional expressions

Behavioral: Mimic facial expressions

Interventions

16 times (4 times a week, last 4 weeks) of mimicking facial expressions.

Higher austic sub-groupLower austic sub-group

Eligibility Criteria

Age17 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Healthy subjects without past or current psychiatric or neurological disorders

You may not qualify if:

  • history of head injury;
  • pregnant, menstruating, taking oral contraceptives;
  • medical or psychiatric illness.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Electronic Science and Technology of China

Chengdu, Sichuan, 611731, China

RECRUITING

Study Officials

  • Weihua Zhao, Dr.

    University of Electronic Science and Technology of China

    STUDY CHAIR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

May 14, 2021

First Posted

June 11, 2021

Study Start

March 30, 2020

Primary Completion

December 30, 2021

Study Completion

March 30, 2022

Last Updated

June 11, 2021

Record last verified: 2021-06

Locations