Standard CPR Versus Chest Compressions Only

NCT04569812 | Completed

• 1 other identifier: 1136/2015
• Study Type: interventional
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

Background: More than two thirds of sudden cardiac arrests are witnessed by bystanders. Bystander cardiopulmonary resuscitation (CPR) doubles survival from cardiac arrest. Importantly, even in witnessed cardiac arrests only 20% of the bystanders commence basic life support. Common reasons for not commencing include panicking and the perceived inability to perform CPR correctly. A meta-analysis could demonstrate that a simplification of the algorithm (compression-only dispatcher-assisted bystander CPR) led to a 22% increase in survival-to-hospital discharge. A recently published trial of the research group could demonstrate that the presence of a flowchart has a positive effect on the quality of BLS while at the same time increasing the rescuers' confidence. Nonetheless, performing CPR is exhausting. Previous publications have emphasized increasing fatigue with the duration of CPR efforts in both, standard and chest compressions-only CPR. Consequently, the investigators wanted to test the hypothesis that chest compressions (CC) are delivered more correctly regarding the depth when utilizing the standard Basic Life Support (BLS) algorithm with the aid of a flowchart as compared to the CC only algorithm utilizing an adapted CPR flowchart in a manikin resuscitation model. Methods: After consent of the Research Ethics Board of Medical University of Vienna and obtaining written informed consent of the participants, 84 medically untrained laypersons will be randomised to perform flow-chart assisted CPR for 300s following standard CPR guidelines or CC only CPR. The primary outcome parameter will be the total number of CC achieving the correct depth of 50-60mm. Secondary outcome parameters will be hands-off time, the total number of CC, and the compression rate. The total number of delivered rescue breaths, tidal volume, and time to deliver these will also be evaluated. Furthermore, the subjective point of exhaustion affecting the CPR quality, the reason for discontinuation of CPR if stopped within the 300sec. period and the exhaustion at the end of the CPR measures will be evaluated.

Conditions

Cardiopulmonary Resuscitation

Keywords

Manikins; Bystander; Quality

Outcome Measures

Primary Outcomes (1)

• total number of CCs that achieved the correct depth of 5-6cm

  correct compression depth according to ERC Guideline 2015

  During 5 minutes CPR

Secondary Outcomes (10)

• hand-off time

  During 5 minutes CPR

• time to the administration of CCs

  During 5 minutes CPR

• total number of CCs

  During 5 minutes CPR

• relative number of correct CCs (%)

  During 5 minutes CPR

• During 5 minutes CPR

  During 5 minute CPR

Study Arms (2)

Standard CPR

EXPERIMENTAL

After Informed Consent Document (ICD) signature, participants were randomised (to the Standard CPR group) to perform standard CPR (30:2) in a flowchart-assisted resuscitation for 5min in a manikin model

Procedure: Cardiopulmonary Resuscitation

Chest compressions only

EXPERIMENTAL

After ICD signature, participants were randomised (to the CC only CPR group) to perform chest compressions only in a flowchart-assisted resuscitation for 5min in a manikin model

Procedure: Cardiopulmonary Resuscitation

Interventions

Cardiopulmonary Resuscitation PROCEDURE

flowchart-assisted standard resuscitation or chest compressions-only resuscitation for 5min

Chest compressions only; Standard CPR

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Volunteers of non-medical professions

You may not qualify if:

• \<18years
• medical professionals
• known pregnancy
• physical impairments or illnesses that prohibited physical

Sponsors & Collaborators

• Medical University of Vienna: lead
• St. John's Ambulance, Vienna Austria: collaborator
• Universitäres Simulationszentrum Wien, Klinik Floridsdorf, Vienna, Austria: collaborator

Study Sites (1)

Medical University of Vienna

Vienna, 1090, Austria

Location

Related Publications (8)

• Sans S, Kesteloot H, Kromhout D. The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J. 1997 Dec;18(12):1231-48. No abstract available.

  PMID: 9508543 BACKGROUND

• Hasselqvist-Ax I, Riva G, Herlitz J, Rosenqvist M, Hollenberg J, Nordberg P, Ringh M, Jonsson M, Axelsson C, Lindqvist J, Karlsson T, Svensson L. Early cardiopulmonary resuscitation in out-of-hospital cardiac arrest. N Engl J Med. 2015 Jun 11;372(24):2307-15. doi: 10.1056/NEJMoa1405796.

  PMID: 26061835 BACKGROUND

• Larsen MP, Eisenberg MS, Cummins RO, Hallstrom AP. Predicting survival from out-of-hospital cardiac arrest: a graphic model. Ann Emerg Med. 1993 Nov;22(11):1652-8. doi: 10.1016/s0196-0644(05)81302-2.

  PMID: 8214853 BACKGROUND

• Nolan JP. Cardiac Arrest and Cardiopulmonary Resuscitation. Semin Neurol. 2017 Feb;37(1):5-12. doi: 10.1055/s-0036-1597832. Epub 2017 Feb 1.

  PMID: 28147412 BACKGROUND

• Savastano S, Vanni V. Cardiopulmonary resuscitation in real life: the most frequent fears of lay rescuers. Resuscitation. 2011 May;82(5):568-71. doi: 10.1016/j.resuscitation.2010.12.010. Epub 2011 Feb 17.

  PMID: 21333434 BACKGROUND

• Perkins GD, Handley AJ, Koster RW, Castren M, Smyth MA, Olasveengen T, Monsieurs KG, Raffay V, Grasner JT, Wenzel V, Ristagno G, Soar J; Adult basic life support and automated external defibrillation section Collaborators. European Resuscitation Council Guidelines for Resuscitation 2015: Section 2. Adult basic life support and automated external defibrillation. Resuscitation. 2015 Oct;95:81-99. doi: 10.1016/j.resuscitation.2015.07.015. Epub 2015 Oct 15. No abstract available.

  PMID: 26477420 BACKGROUND

• Hupfl M, Selig HF, Nagele P. Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis. Lancet. 2010 Nov 6;376(9752):1552-7. doi: 10.1016/S0140-6736(10)61454-7. Epub 2010 Oct 14.

  PMID: 20951422 BACKGROUND

• Rossler B, Ziegler M, Hupfl M, Fleischhackl R, Krychtiuk KA, Schebesta K. Can a flowchart improve the quality of bystander cardiopulmonary resuscitation? Resuscitation. 2013 Jul;84(7):982-6. doi: 10.1016/j.resuscitation.2013.01.001. Epub 2013 Jan 7.

  PMID: 23306815 BACKGROUND

MeSH Terms

Interventions

Cardiopulmonary Resuscitation

Intervention Hierarchy (Ancestors)

Resuscitation; Emergency Treatment; Therapeutics

Study Officials

• Bernhard Roessler, MD

  Medical University of Vienna

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. PD Dr.

Model Details: prospective, randomized controlled study

Study Record Dates

• First Submitted: September 9, 2019
• First Posted: September 30, 2020
• Study Start: March 23, 2015
• Primary Completion: April 20, 2016
• Study Completion: April 20, 2016
• Last Updated: October 1, 2020

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)