Yoga, Aerobic and Stretching Exercise Effects on Neurocognition

NCT04323163 | Completed DMC

• 1 other identifier: 20714
• Study Type: interventional
• Target: 145
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators propose to conduct a 6-month 3-arm randomized controlled exercise trial among older adults to compare the efficacy of yoga with aerobic exercise and stretching-toning exercises on cognitive function, brain structure and function, cardiorespiratory fitness, functional fitness, and inflammatory and molecular markers. Using a single-blind, three arm randomized control trial, 168 older adults ages 55-79 will be assigned to either: a Hatha yoga group, an aerobic exercise group or an active stretching and toning control group. The groups will engage in hour-long group exercise sessions 3x/week. A comprehensive neurocognitive test battery, brain imaging, cardiovascular fitness test, and a blood draw will take place at baseline; end of the 6-month intervention, and at 12-month follow-up. The proposed work will examine the relationship between yoga training and improved cognitive functioning as well as identify neurobiological correlates as potential mechanisms of action through which yoga training exerts its effect on cognitive function. COVID-19 Precautions: Due to COVID-19, all exercise sessions will be conducted live via Zoom video-conferencing such that 1/3rd of the participants in each group will exercise in person with the research staff at UIUC campus once a week while the remaining 2/3rd will tune in via Zoom

Conditions

Aging; Cognitive Decline

Outcome Measures

Primary Outcomes (1)

• Change in cognitive function

  A comprehensive neuropsychological battery (part of the NIH toolbox) will be used that assesses different domains of cognitive function, including working memory, attention and executive function.

  Baseline, 6 months, 12 months

Secondary Outcomes (2)

• Change in brain structure

  Baseline, 6 months, 12 months

• Change in brain function

  Baseline, 6 months, 12 months

Other Outcomes (2)

• Changes in physiological biomarkers

  Baseline, 6 months, 12 months

• Changes in cardiovascular fitness

  Baseline, 6 months, 12 months

Study Arms (3)

Yoga Group

EXPERIMENTAL

Participants will be led through a beginner yoga course taught by a certified yoga instructor. Classes will meet three times a week for 60 minutes over the 6 month study duration. Sessions will focus on yoga postures, breathing, and meditative practices and may utilize mats, blocks, belts, and blankets.

Behavioral: Physical Activity

Aerobic Group

EXPERIMENTAL

Trained exercise instructors will lead participants through an aerobic group exercise class. Sessions will begin with a 15-20 minute aerobics class and increase in duration over the 6 months capping off at 40-minutes per session. The prescribed intensity will be 50-60% of the maximum heart rate reserve for weeks one to six and 60-75% for the remainder of the program.

Behavioral: Physical Activity

Stretching Toning Group

ACTIVE COMPARATOR

Participants randomized to this group will meet three times a week for an hour-long structured group exercise session. This group will perform stretching and toning exercises using resistance bands, balance disks, and exercise mats.

Behavioral: Physical Activity

Interventions

Physical Activity BEHAVIORAL

3 sessions per week, 60 minutes per session for 6 months

Aerobic Group; Stretching Toning Group; Yoga Group

Eligibility Criteria

• Age: 55 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age at study enrollment
• TICS-M score of 32 or higher
• No current or past diagnosis of mild cognitive impairment or dementias
• Low-active (≤ 2 days of 30 minutes of structured exercise/week)
• Physician's consent to participate in VO2max testing and the exercise program
• Ambulatory
• Absence of health conditions that may be exacerbated by exercise
• Good or corrected vision and hearing
• No MRI contraindications (e.g. metal or implanted devices in the body)
• Right-handed
• Intention to remain in the Champaign-Urbana area over the study duration

You may not qualify if:

• Below 55 or above 79 years of age at study enrollment
• TICS-M score of 31 or lower
• Current or past diagnosis of mild cognitive impairment or dementias
• High-active (3 or more days of 30 minutes of structured exercise/week)
• Physician's non-consent to participate in VO2max testing and the exercise program
• Non-ambulatory (use of wheelchairs or walkers)
• Presence of health conditions that may be exacerbated by exercise
• Poor vision and hearing
• MRI contraindications (e.g. metal or implanted devices in the body)
• Left-handed
• Plans to travel outside of Champaign-Urbana area during the study

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead
• Wayne State University: collaborator

Study Sites (1)

University of Illinois at Urbana-Champaign

Urbana, Illinois, 61801, United States

Location

Related Publications (1)

• Gothe NP, Erlenbach E, Garcia V, Malani R, Voss S, Camacho PB, McAuley E, Burd N, Sutton BP, Damoiseaux JS. Yoga, aerobic and stretching exercise effects on neurocognition: Randomized controlled trial protocol. Contemp Clin Trials. 2023 Aug;131:107240. doi: 10.1016/j.cct.2023.107240. Epub 2023 May 25.

  PMID: 37244365 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Exercise

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Neha P Gothe, MA, PhD

  University of Illinois at Urbana-Champaign

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 18, 2020
• First Posted: March 26, 2020
• Study Start: January 6, 2021
• Primary Completion: August 31, 2023
• Study Completion: May 31, 2024
• Last Updated: July 31, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)