A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease
FIND-CKD
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Phase 3 Study to Investigate the Efficacy and Safety of FInerenone, in Addition to Standard of Care, on the Progression of Kidney Disease in Patients With Non-Diabetic Chronic Kidney Disease
2 other identifiers
interventional
1,584
24 countries
326
Brief Summary
Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD. In this trial, the researchers want to learn if finerenone helps to slow down the worsening of the participants' non-diabetic CKD compared to a placebo. A placebo looks like a trial treatment but does not have any medicine in it. The trial will include about 1,580 men and women who are at least 18 years old. The participants will take finerenone or a placebo once a day as tablets by mouth. All of the participants will also continue to take their current medicine for their CKD. The participants will be in the trial for up to about 50 months. During the trial, the doctors will collect blood and urine samples and check the participants' health. The participants will also answer questions about how they are feeling and what adverse events they are having. An adverse event is a medical problem that happens during the trial. Doctors keep track of all adverse events that happen in trials, even if they do not think the adverse events might be related to the trial treatments.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Sep 2021
Typical duration for phase_3
326 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 12, 2021
CompletedFirst Posted
Study publicly available on registry
September 17, 2021
CompletedStudy Start
First participant enrolled
September 21, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 2, 2026
CompletedFebruary 13, 2026
February 1, 2026
4.3 years
September 12, 2021
February 12, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Mean rate of change as measured by the total slope of eGFR from baseline to Month-32.
eGFR: Estimated glomerular filtration rate
From baseline to month 32
Secondary Outcomes (4)
Time to the composite of kidney failure, sustained eGFR decline of >= 57%, heart failure hospitalization or Cardiovascular (CV) death
Up to end of study visit (up to approximately 49 months)
Time to the composite of kidney failure or sustained eGFR decline of >= 57%
Up to end of study visit (up to approximately 49 months)
Time to the composite to heart failure hospitalization or CV death
Up to end of study visit (up to approximately 49 months)
Number of participants with Treatment-emergent adverse events (TEAEs), Treatment-emergent serious adverse events (TESAEs) and Adverse events of special interest (AESI)
Up to approximately 50 months
Study Arms (2)
Finerenone (BAY94-8862)
EXPERIMENTALParticipants will receive finerenone.
Placebo
PLACEBO COMPARATORParticipants will receive placebo.
Interventions
Eligibility Criteria
You may qualify if:
- A clinical diagnosis of chronic kidney disease and:
- Urine albumin/creatinine ratio (UACR) of ≥ 200 but ≤ 3500 mg/g and estimated glomerular filtration rate (eGFR) ≥ 25 but \< 90 mL/min/1.73m\^2 at screening, and
- Documentation of albuminuria/proteinuria in the participant's medical records at least 3 months prior to screening.
- Stable and maximum tolerated labeled dose of an Angiotensin-converting enzyme inhibitor (ACEI) or Angiotensin receptor blocker (ARB) for at least 4 weeks prior to screening
- K+ ≤ 4.8 mmol/L at screening
You may not qualify if:
- Established diagnosis of Type 1 or 2 Diabetes mellitus, or HbA1c ≥ 6.5% (48 mmol/mol)
- Autosomal dominant or autosomal recessive polycystic kidney disease
- Lupus nephritis or anti-neutrophilic cytoplasmic autoantibody (ANCA) -associated vasculitis or any other primary or secondary kidney disease requiring immunosuppressive therapy within 6 months prior to screening
- Symptomatic heart failure with reduced ejection fraction with class 1A indication for Mineralocorticoid receptor antagonists (MRAs)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bayerlead
Study Sites (326)
Nephrology Consultants, LLC
Huntsville, Alabama, 35805, United States
Balboa Research SMO+ - Chula Vista - West
Chula Vista, California, 91910, United States
Balboa Research SMO+ - El Centro
El Centro, California, 92243, United States
UCLA Clinical and Translational Research Center - Nephrology
Los Angeles, California, 90095, United States
Balboa Nephrology Medical Group - Poway
Poway, California, 92064, United States
North America Research Institute - San Dimas
San Dimas, California, 91773, United States
United Clinical Research & Innovations
South Gate, California, 90280, United States
University of Colorado | Renal Research Office
Aurora, Colorado, 80045, United States
DaVita Clinical Research | Middlebury, CT
Middlebury, Connecticut, 55404, United States
Yale University | Nephrology Clinical Research
New Haven, Connecticut, 06520, United States
Chase Medical Research, LLC
Waterbury, Connecticut, 06708, United States
Research Physicians Network Alliance
Boca Raton, Florida, 33431, United States
Florida Kidney Physicians - Boca Raton
Boca Raton, Florida, 33487, United States
AdventHealth Translational Research Institute
Orlando, Florida, 32804, United States
Grady Memorial Hospital - Endocrinology
Atlanta, Georgia, 30303, United States
Southeastern Clinical Research Institute, LLC
Augusta, Georgia, 30904, United States
Central Georgia Kidney Specialists - Macon
Macon, Georgia, 31201, United States
Frenova Renal Research | Boise Kidney and Hypertension
Meridian, Idaho, 83642, United States
Northwestern Medicine - Feinberg School of Medicine - Nephrology and Hypertension
Chicago, Illinois, 60611, United States
Research by Design, LLC | Chicago, IL
Chicago, Illinois, 60643, United States
Nephrology Associates of Northern Illinois and Indiana - Hinsdale
Hinsdale, Illinois, 60521, United States
University of Iowa Health Care Medical Center - Cardiology
Iowa City, Iowa, 52242, United States
KUMC Clinical and Translational Science Unit - Nephrology
Kansas City, Kansas, 66160, United States
Kansas Nephrology Research Institute
Wichita, Kansas, 67214, United States
Wichita Nephrology Group, PA
Wichita, Kansas, 67214, United States
Northwest Louisiana Nephrology - Shreveport - 1800 Buckner St.
Shreveport, Louisiana, 71101, United States
Johns Hopkins Hospital - Nephrology
Baltimore, Maryland, 21287, United States
Tufts Medical Center | Nephrology Department
Boston, Massachusetts, 02111, United States
DaVita Clinical Research | Edina, MN
Edina, Minnesota, 55435, United States
University Hospital - UMMC - Nephrology
Jackson, Mississippi, 39216, United States
Clinical Research Consultants, a JCCT Company
Kansas City, Missouri, 64111, United States
St. Louis Heart and Vascular, PC - Christian Hospital Office
St Louis, Missouri, 63136, United States
UNM Clinical and Translational Science Center - Nephrology
Albuquerque, New Mexico, 87131, United States
Mountain Kidney & Hypertension Associates
Asheville, North Carolina, 28801, United States
UNC Hospitals Outpatient Center at Eastowne - Nephrology
Chapel Hill, North Carolina, 27514, United States
East Carolina University | Nephrology & Hypertension
Greenville, North Carolina, 27834, United States
Eastern Nephrology Associates | Wilmington
Wilmington, North Carolina, 28401, United States
UH Cleveland Medical Center - Nephrology
Cleveland, Ohio, 44106, United States
Cleveland Clinic | Urological and Kidney Department
Cleveland, Ohio, 44195, United States
Northeast Clinical Research Center | Bethlehem, PA
Bethlehem, Pennsylvania, 18017, United States
Geisinger Medical Center - Nephrology
Danville, Pennsylvania, 17822, United States
Temple Health - Nephrology
Philadelphia, Pennsylvania, 19140, United States
South Carolina Clinical Reserach
Orangeburg, South Carolina, 29118, United States
Knoxville Kidney Center, PLLC
Knoxville, Tennessee, 37923, United States
Vanderbilt University Medical Center - Nephrology Clinical Trials Center
Nashville, Tennessee, 37232, United States
Dallas Renal Group - Medical City
Dallas, Texas, 75230, United States
El Paso Medical Research Institute (MedResearch Inc) | El Paso, TX
El Paso, Texas, 79902, United States
DaVita Clinical Research | Houston, TX
Houston, Texas, 77054, United States
Gamma Medical Research, Inc.
McAllen, Texas, 78503, United States
Texas Diabetes Institute - Renal Clinic
San Antonio, Texas, 78207, United States
Clinical Advancement Center, PLLC
San Antonio, Texas, 78212, United States
DaVita Clinical Research | North Houston, TX
Shenandoah, Texas, 77384, United States
University of Utah School of Medicine | Kidney Research Clinic
Salt Lake City, Utah, 84132, United States
Utah Kidney Research Institute | Salt Lake City, UT
South Salt Lake, Utah, 84115, United States
Nephrology Associates of Northern Virginia - Fair Oaks
Fairfax, Virginia, 22033, United States
Mendez Center For Clinical Research | Woodbridge, VA
Woodbridge, Virginia, 22192, United States
Providence Medical Research Center
Spokane Valley, Washington, 99204, United States
Asociacion de Fomento y Sala de Primeros Auxilios Alberto Mignaburu | Berazategui, Argentina
Berazategui, Buenos Aires, B1837, Argentina
Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina
Ciudad Autónoma de Buenos Aire, Buenos Aires, C1056ABI, Argentina
Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina
Lanús, Buenos Aires, B1824, Argentina
Instituto de Investigaciones Clinicas de Mar del Plata | Mar del Plata, Argentina
Mar del Plata, Buenos Aires, B7600FZ0, Argentina
CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina
CABA, Ciudad Auton. de Buenos Aires, C1018DES, Argentina
Centro de Rehabilitacion Cardiovascular | San Luis, Argentina
San Luis, San Luis Province, D5700CGR, Argentina
Centro de Investigación y Prevención Cardiovascular
Buenos Aires, C1061AAS, Argentina
Clinica Privada Velez Sarsfield
Córdoba, X5016KET, Argentina
Clinica de Nefrologia Urologia y Enfermedades Cardiovascular
Santa Fe, 3000, Argentina
Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina
Santa Fe, S3000FWO, Argentina
Concord Repatriation General Hospital
Concord, New South Wales, 2139, Australia
St George Hospital
Kogarah, New South Wales, 2217, Australia
Illawarra Shoalhaven Local Health District
Wollongong, New South Wales, 2500, Australia
Sunshine Coast University Hospital
Birtinya, Queensland, 4575, Australia
Princess Alexandra Hospital Australia
Woolloongabba, Queensland, 4102, Australia
Eastern Health Integrated Renal Service
Box Hill, Victoria, 3128, Australia
Melbourne Renal Research Group
Reservoir, Victoria, 3073, Australia
Sunshine Hospital
St Albans, Victoria, 3021, Australia
AZ Groeninge Campus Kennedylaan | Nephrology
Kortrijk, West-Vlaanderen, 8500, Belgium
CU Saint-Luc/UZ St-Luc
Bruxelles - Brussel, 1200, Belgium
UZ Gent
Ghent, 9000, Belgium
UZ Leuven Gasthuisberg
Leuven, 3000, Belgium
CHU de Liège
Liège, 4000, Belgium
AZ Delta / Nephrology
Roeselare, 8800, Belgium
Medical Center ''4Life''
Burgas, Burgas Province, 8000, Bulgaria
Viva Phoenix Medical Center | Clinical Trials Department
Dobrich, Dobrich Province, 9300, Bulgaria
Medical Center Hera | Montana Branch
Montana, Montana Province, 3400, Bulgaria
Multiprofile Hospital for Active Treatment Sveti Georgi OOD, Pernik - Department of Cardiology
Pernik, Pernik Province, 2300, Bulgaria
Diagnostic-Consultative Center XX | Nephrology Department
Sofia, Sofia City Province, 1618, Bulgaria
Medical Center Zara-Med EOOD | Nephrology Department
Stara Zagora, Stara Zagora Province, 6010, Bulgaria
Multiprofile Hospital for Active Treatment St. Ivan Rilski - Gorna Oryahovitsa | Nephrology Department
Gorna Oryahovitsa, Veliko Tarnovo Province, 5100, Bulgaria
Medical Center ''Nevromedics''
Veliko Tarnovo, Veliko Tarnovo Province, 5600, Bulgaria
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, MISSING, China
The Second Hospital of Anhui medical university
Hefei, Anhui, 230601, China
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian, 361003, China
Lanzhou University Second Hospital
Lanzhou, Gansu, 730030, China
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, 510280, China
The First Affiliated Hospital of Guangzhou University of TCM
Guangzhou, Guangdong, 510405, China
The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510630, China
Huizhou Central People's Hospital
Huizhou, Guangdong, 516001, China
Jiangmen Wuyi Hospital of traditional Chinese Medicine
Jiangmen, Guangdong, 529099, China
Liuzhou Worker's Hospital
Liuchow, Guangxi, 545005, China
People's Hospital of Liuzhou City
Liuchow, Guangxi, 545006, China
The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, Guangxi, 530021, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, 550004, China
The First affiliated Hospital of Hebei North University
Zhangjiakou, Hebei, 075000, China
Wuhan Hospital Of Traditional Chinese And Western Medicine
Wuhan, Hubei, 430022, China
Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech
Wuhan, Hubei, 430034, China
Renmin Hosp., Wuhan Univ.
Wuhan, Hubei, 430040, China
The First Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, 14010, China
1st Peopl's Hosp of Changzhou 3rd Affil Hosp of Soochow Univ
Changzhou, Jiangsu, 213003, China
Huai'an First People's Hospital, Nanjing Medical University
Huai'an, Jiangsu, 223300, China
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 210009, China
Jiangsu Province Hospital of Chinese Medicine
Nanjing, Jiangsu, 210029, China
The First Affiliated Hospital of NanChang University
Nanchang, Jiangxi, 330006, China
Jiangxi PingXiang people's Hospital
Pingxiang, Jiangxi, 337055, China
The Second Hospital of Jilin University
Changchun, Jilin, 130000, China
Siping Central Hospital
Siping, Jilin, MISSING, China
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, 116011, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, 750004, China
Qilu Hosp., Shandong Univ.
Jinan, Shandong, 250000, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, 710061, China
SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos
Chengdu, Sichuan, 610072, China
Sichuan University West China Hospital
Chengdu, Sichuan, MISSING, China
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, 830011, China
Hwa Mei Hospital, University of Chinese Academy Sciences
Ningbo, Zhejiang, 31510, China
The First Affiliated Hospital of Wenzhou Medical Univ (New)
Wenzhou, Zhejiang, 325000, China
Beijing Anzhen Hospital, Capital Medical University
Beijing, 100029, China
China-Japan Friendship Hospital
Beijing, 100029, China
Chinese PLA General Hospital
Beijing, 100853, China
Beijing Tsinghua Changgung Hospital
Beijing, 102218, China
Daping Hospital, 3rd Affil Hosp. 3rd Military Med Univ PLA
Chongqing, 400042, China
Zhongshan Hospital, Fudan University - Oncology Department
Shanghai, 200032, China
Xinhua Hos Affiliated to SH Jiaotong Uni School of Medicine
Shanghai, 200092, China
Shanghai Fifth People's Hospital,Fudan University
Shanghai, 200240, China
Central Hospital of Minhang District, Shanghai
Shanghai, 201199, China
Tianjin Union Medicine Centre (People's Hospital of Tianjin)
Tianjin, 300121, China
Fakultní nemocnice Brno - Interní gastroenterologická klinika
Brno, South Moravian, 625 00, Czechia
MUDr.Petr Bucek s.r.o.
Frýdek-Místek, 738 01, Czechia
CTC Hodonín, s.r.o.
Hodonín, 695 01, Czechia
Fakultni nemocnice Ostrava
Ostrava, 708 52, Czechia
Privamed s.r.o.
Pilsen, 323 33, Czechia
Všeobecná fakultní nemocnice v Praze
Prague, 12808, Czechia
Nefrologicka ambulance
Prague, 140 00, Czechia
Nefromed s.r.o.
Prague, 160 00, Czechia
Vestra Clinics s.r.o.
Rychnov nad Kněžnou, 516 01, Czechia
Nemocnice Znojmo
Znojmo, 669 02, Czechia
Rigshospitalet, Copenhagen University Hospital | Department of Nefrology
Copenhagen, 2100, Denmark
Hospital of South West Jutland | Department of Endocrinology Research
Esbjerg, 6700, Denmark
Herlev Hospital | Nephrology Department
Herlev, 2730, Denmark
Region Midtjylland | Regionshospitalet Godstrup - Nephrology Department
Herning, DK-7400, Denmark
Region Sjælland | Holbaek Sygehus - Cardiology department
Holbæk, 4300, Denmark
Odense University Hospital | Department of Kidney Medicine
Odense C, 5000, Denmark
University General Hospital of Patras | Nephrology Clinic
Pátrai, Achaia, 26504, Greece
General Hospital Of Thessaloniki Papageorgiou-Renal Department
Efkarpia, Thessaloniki, 56429, Greece
General Hospital of Arta | Nephrology Department
Arta, 47132, Greece
General Hospital of Athens LAIKO
Athens, 11527, Greece
HIPPOKRATION General Hospital of Athens
Athens, 11527, Greece
University General Hospital of Heraklion-Nephrology Clinic
Heraklion, 71500, Greece
University General Hospital Of Ioannina-Nephrology Clinic
Ioannina, 45500, Greece
Ippokratio General Hospital Of Thessaloniki- 1st Department of Nephrology
Thessaloniki, 54642, Greece
Geniko Nosokomeio Thessalonikis George Papanikolaou-Nephrology Department
Thessaloniki, 57010, Greece
Tung Wah Hospital
Sheung Wan, Hong Kong Island, 00000, Hong Kong
Prince of Wales Hospital
Hong Kong, Hong Kong SAR, 00000, Hong Kong
Princess Margaret Hospital
Hong Kong, Hong Kong SAR, 00000, Hong Kong
Queen Mary Hospital
Hong Kong, Hong Kong SAR, 00000, Hong Kong
Del-pesti Centrumkorhaz - Orszagos Hematologiai és Infektologiai Intezet
Budapest, 1097, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz
Kaposvár, 7400, Hungary
Kistarcsai Flor Ferenc Korhaz
Kistarcsa, 2143, Hungary
Nagykanizsai Kanizsai Dorottya Korhaz
Nagykanizsa, 8800, Hungary
Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.
Nyíregyháza, 4400, Hungary
Pecsi Tudomanyegyetem Klinikai Kozpont
Pécs, 7624, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz
Szombathely, 9700, Hungary
Mavani Research Center
Ahmedabad, Gujarat, 380052, India
Shalby Hospital
Ahmedabad, Gujarat, 380054, India
Government Medical College Thiruvananthapuram
Thiruvananthapuram, Kerala, 695011, India
Noble Hospital
Hadapsar, Maharashtra, 411013, India
P. D. Hinduja Hospital and Medical Research Centre
Mumbai, Maharashtra, 400016, India
Shree Siddhivinayak Maternity & Nursing Home
Nashik, Maharashtra, 422002, India
Max Super Speciality Hospital, Saket
New Delhi, National Capital Territory of Delhi, 110017, India
All India Institute of Medical Sciences
Bhubaneswar, Odisha, 751019, India
Madras Medical College
Chennai, Tamil Nadu, 600003, India
Osmania General Hospital
Telangana, Telangana, 500012, India
Institute of Post-Graduate Medical Education and Research
Kolkata, West Bengal, 700020, India
Assuta Ashdod Public Hospital (R.A)
Ashdod, 7747629, Israel
Barzilai Medical Center | Department of Nephrology and Hypertension
Ashkelon, 7830604, Israel
Clalit Health | Soroka Medical Center - Internal Medicine Department
Beersheba, 8410101, Israel
Rambam Health Corporation
Haifa, 3109601, Israel
Meir Medical Center
Kfar Saba, 4428164, Israel
Health Corporation of Galilee Medical Center
Nahariya, 2210001, Israel
Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department
Petah Tikva, 4941492, Israel
Chaim Sheba Medical Center
Ramat Gan, 5262000, Israel
Kaplan Medical Center
Rehovot, 7610001, Israel
Tel-Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
Poria Medical Center | Nephrology and Hypertension Department
Tiberias, 1528001, Israel
Shamir Medical Center (Assaf Harofeh)
Ẕerifin, 7030000, Israel
A.O.U. Universita' Degli Studi Della Campania Luigi Vanvitelli - Nefrologia
Naples, Campania, 80131, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto
Bologna, Emilia-Romagna, 40138, Italy
Azienda Ospedaliero Universitaria di Modena_Policlinico - Nefrologia, Dialisi e Trapianto di Rene
Modena, Emilia-Romagna, 41124, Italy
Azienda Ospedaliero Universitaria Parma - SC Nefrologia
Parma, Emilia-Romagna, 43126, Italy
Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Nefrologia e Dialisi
Reggio Emilia, Emilia-Romagna, 42123, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Nefrologia
Rome, Lazio, 00168, Italy
Azienda Socio Sanitaria Territoriale Della Brianza_Ospedale Pio XI - Nefrologia e Dialisi
Desio, Lombardy, 20832, Italy
Azienda Socio Sanitaria Territoriale Ovest Milanese_Legnano - Nefrologia e Dialisi
Legnano, Lombardy, 20025, Italy
Istituti Clinici Scientifici Maugeri S.p.A._Pavia - Nefrologia
Pavia, Lombardy, 27100, Italy
Istituto Ricerche Farmacologiche Mario Negri - Unità Operativa Complessa Malattie Renali
Ranica, Lombardy, 24020, Italy
Azienda Socio Sanitaria Territoriale Rhodense
Rho, Lombardy, 20017, Italy
Azienda Ospedaliera Per L'Emergenza Cannizzaro - Nefrologia e Dialisi
Catania, Sicily, 95126, Italy
Chubu Rosai Hospital
Nagoya, Aichi-ken, 455-8530, Japan
Daido Clinic
Nagoya, Aichi-ken, 457-8511, Japan
Nagoya City University Hospital
Nagoya, Aichi-ken, 467-8602, Japan
Kainan Hospital
Yatomi, Aichi-ken, 498-8502, Japan
Juntendo University Urayasu Hospital
Urayasu, Chiba, 279-0021, Japan
Aso Iizuka Hospital
Iizuka, Fukuoka, 820-8505, Japan
Kokura Memorial Hospital
Kitakyushu, Fukuoka, 802-8555, Japan
JCHO Kyushu Hospital
Kitakyushu, Fukuoka, 806-8501, Japan
Central Japan International Medical Center
Minokamo, Gifu, 505-8510, Japan
Kobe University Hospital
Kobe, Hyōgo, 650-0017, Japan
Hyogo Prefectural Nishinomiya Hospital
Nishinomiya, Hyōgo, 662-0918, Japan
JA Toride Medical Center
Toride, Ibaraki, 302-0022, Japan
Tsuchiura Kyodo General Hospital
Tsuchiura, Ibaraki, 300-0028, Japan
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, 920-8641, Japan
National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office
Kanazawa, Ishikawa-ken, 920-8650, Japan
Iwate Prefectural Central Hospital
Morioka, Iwate, 020-0066, Japan
Hiratsuka Kyosai Hospital
Hiratsuka, Kanagawa, 254-8502, Japan
Tokai University Hospital
Isehara, Kanagawa, 259-1193, Japan
St. Marianna University Hospital
Kawasaki, Kanagawa, 216-8511, Japan
Saiseikai Yokohamashi Nanbu Hospital
Yokohama, Kanagawa, 234-0054, Japan
Yokohama City University Hospital
Yokohama, Kanagawa, 236-0004, Japan
Yokohama Sakae Kyosai Hospital
Yokohama, Kanagawa, 247-8581, Japan
Matsumoto City Hospital
Matsumoto, Nagano, 390-1401, Japan
Shinshu University Hospital
Matsumoto, Nagano, 390-8621, Japan
Kawasaki Medical School Hospital
Kurashiki, Okayama-ken, 701-0192, Japan
Osaka Rosai Hospital
Sakai, Osaka, 591-8025, Japan
Saitama Medical University Hospital
Irima-gun, Saitama, 350-0495, Japan
Koshigaya Municipal Hospital
Koshigaya, Saitama, 343-8577, Japan
Seirei Hamamatsu General Hospital
Hamamatsu, Shizuoka, 430-8558, Japan
Juntendo University Hospital
Bunkyo-ku, Tokyo, 113-8431, Japan
The University of Tokyo Hospital
Bunkyo-ku, Tokyo, 113-8655, Japan
Tokyo Metropolitan Tama Medical Center
Fuchū, Tokyo, 183-8524, Japan
Nihon University Itabashi Hospital
Itabashi-ku, Tokyo, 173-8610, Japan
Tokyo Medical University Hospital
Shinjuku-ku, Tokyo, 160-0023, Japan
University of Yamanashi Hospital
Chūō, Yamanashi, 409-3898, Japan
Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital
Fukuoka, 811-0213, Japan
Fukuoka University Hospital
Fukuoka, 814-0180, Japan
Japanese Red Cross Kumamoto Hospital
Kumamoto, 861-8520, Japan
Nara Prefecture General Medical Center
Nara, 630-8581, Japan
Saga-Ken Medical Centre Koseikan
Saga, 840-8571, Japan
Japanese Red Cross Saitama Hospital
Saitama, 330-8553, Japan
Hospital Selayang
Shah Alam, Selangor, 68100, Malaysia
Hospital Sultan Abdul Halim
Kedah, 8000, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, 50586, Malaysia
Universiti Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
Hospital Tengku Ampuan Afzan
Kuala Pahang, 25100, Malaysia
Hospital Kajang
Kuala Selangor, 43000, Malaysia
Hospital Pakar Sultanah Fatimah
Muar town, 84000, Malaysia
Hospital Tuanku Jaafar | Nephrology Department
Negeri Sembilan, 70300, Malaysia
Hospital Raja Permaisuri Bainun
Perak, 30450, Malaysia
Hospital Seri Manjung
Perak, 32040, Malaysia
Hospital Pulau Pinang
Pulau Pinang, 10450, Malaysia
Fundacion Cardiovascular de Aguascalientes | Aguascalientes, Mexico
Missing, Aguascalientes, 20230, Mexico
SINACOR | Culiacan, Mexico
Culiacán, Sinaloa, 80230, Mexico
Sociedad de Metabolismo y Corazon S.C. | Veracruz, Mexico
Puerto de Veracruz, Veracruz, 91900, Mexico
Sitio Alfredo Chew Wong | Aguascalientes, Mexico
Aguascalientes, 20124, Mexico
Unidade Local De Saúde De Lisboa Ocidental E.P.E.
Carnaxide, Lisbon District, 2790-134, Portugal
Centro Hospitalar do Medio Tejo | Unidade de Torres Novas - Nephrology Department
Torres Novas, Santarém District, 2350-754, Portugal
Unidade Local de Saude Almada-Seixal | Hospital Garcia de Orta - Research Department
Almada, Setúbal District, 2805-267, Portugal
Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center
Leiria, 2410-197, Portugal
Centro Hospitalar Universitario de Lisboa Central | Hospital Curry Cabral - Nephrology Department
Lisbon, 1069-166, Portugal
First City Clinical Hospital n.a. E.E. Volosevich
Arkhangelsk, 163001, Russia
Izhevsk City Clinical Hospital #9
Izhevsk, 426063, Russia
Kemerovo Regional Clinical Hospital
Kemerovo, 650066, Russia
City clinical hospital n.a. V.V. Vinogradov
Moscow, 117292, Russia
City Hospital #52
Moscow, 123182, Russia
City Clinical Hospital of Emergency Care #1
Omsk, 644112, Russia
Rostov State Medical University
Rostov-on-Don, 344022, Russia
Limited liability company "MK-Med"
Saint Petersburg, 197082, Russia
Saratov City Clinical Hospital #9
Saratov, 410030, Russia
City clinical hospital #40 Sestroretsk
Sestroretsk, 197706, Russia
Voronezh Regional Clinical Consultancy-Diagnostic Center
Voronezh, 394018, Russia
Regional Clinical Hospital Yaroslavl
Yaroslavl, 150062, Russia
National University Hospital Medical Centre
Singapore, 119074, Singapore
Singapore General Hospital
Singapore, 169608, Singapore
Tan Tock Seng Hospital
Singapore, 308433, Singapore
SingHealth Polyclinics - Pasir Ris
Singapore, 519457, Singapore
Khoo Teck Puat Hospital
Singapore, 768828, Singapore
Yonsei University Wonju Christian Hospital
Wŏnju, Gang''weondo, 26426, South Korea
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggido, 14068, South Korea
Dongguk University Ilsan Hospital
Goyang-si, Gyeonggido, 10326, South Korea
Inje University Ilsan Paik Hospital
Goyang-si, Gyeonggido, 411-706, South Korea
CHA Bundang Medical Center | Nephrology
Seongnam-si, Gyeonggido, 13496, South Korea
The Catholic University of Korea, Incheon St.Mary's Hospital
Incheon, Incheon Gwang''yeogsi, 21431, South Korea
Kangdong Sacred Heart Hospital
Teugbyeolsi, Seoul, 134-701, South Korea
The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital
Seoul, Seoul Teugbyeolsi, 03312, South Korea
Severance Hospital, Yonsei University Health System - Cardiology
Seoul, Seoul Teugbyeolsi, 03722, South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, 3080, South Korea
Inje University Busan Paik Hospital
Busan, 47392, South Korea
Chung Nam National University Hospital
Daejeon, 35015, South Korea
Ansan Hospital | Nephrology
Gyeonggi-do, 425-707, South Korea
Samsung Medical Center - Cardiology
Seoul, 06351, South Korea
Kyung Hee University Hospital at Gangdong
Seoul, 5278, South Korea
Seoul National University Boramae Medical Center
Seoul, 7061, South Korea
Kangnam Sacred Heart Hospital
Seoul, 7441, South Korea
Area Sanitaria De Ferrol | Medicina Interna
Ferrol, A Coruña, 15405, Spain
Bellvitge Hospital Universitari | Nefrologia
L'Hospitalet de Llobregat, Barcelona, 8907, Spain
Hospital Publico Da Marina | Nefrologia
Burela de Cabo, Lugo, 27880, Spain
Hospital Universitario Central De Asturias | Nefrologia
Alcalá de Henares, Madrid, 28805, Spain
Hospital del Mar | Nephrology Department
Barcelona, 08003, Spain
Hospital Universitari Vall D Hebron | Nefrologia
Barcelona, 08035, Spain
Hospital Universitario Ramon Y Cajal | Medicina Interna
Madrid, 28034, Spain
Hospital Universitario 12 De Octubre | Nefrologia
Madrid, 28041, Spain
Hospital Clinico Universitario De Valencia | Nefrologia
Valencia, 46010, Spain
Hospital Universitario Dr Peset Aleixandre | Nefrologia
Valencia, 46017, Spain
Hospital Universitario Y Politecnico La Fe | Nefrologia
Valencia, 46026, Spain
National Taiwan University Hospital, Hsin-Chu Branch
Taoyuan District, Hsinchu, 300, Taiwan
Far Eastern Memorial Hospital | Nephrology Department
New Taipei City, Taipei, 220, Taiwan
Changhua Christian Hospital
Changhua, 50006, Taiwan
Chang Gung Memorial Hospital Kaohsiung
Kaohsiung City, 833, Taiwan
China Medical University Hospital
Taichung, 404327, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Taipei Medical University | Clinical Research Center
Taipei, 110, Taiwan
Chang Gung Memorial Hospital at Linkou
Taoyuan District, 33305, Taiwan
Barts Health NHS Trust - Royal London Hospital - Nephrology
London, Greater London, E1 1BB, United Kingdom
King's College Hospital NHS Foundation Trust | King's College Hospital - Nephrology Department
London, Greater London, SE5 9RS, United Kingdom
Kent and Canterbury Hospital | Renal Research Delivery Team
Canterbury, Kent, CT1 3NG, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust | Northern General Hospital - NIHR Sheffield Clinical Research Facility
Sheffield, South Yorkshire, S5 7AU, United Kingdom
Cardiff and Vale University Health Board | University Hospital of Wales - Nephrology and Transplant
Cardiff, Wales, CF14 4XW, United Kingdom
Gloucestershire Hospitals NHS Foundation Trust | Gloucestershire Royal Hospital - Nephrology
Gloucester, GL1 3NN, United Kingdom
Related Publications (2)
Ostrominski JW, Filippatos G, Claggett BL, Miao ZM, Desai AS, Jhund PS, Henderson A, Rohwedder K, Brinker MD, Scalise A, Schloemer P, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Rossing P, Ruilope LM, Anker SD, Pitt B, Agarwal R, McMurray JJV, Solomon SD, Vaduganathan M. Effect of Finerenone on Morbidity and Mortality in CKD. J Am Soc Nephrol. 2026 Feb 1;37(2):312-325. doi: 10.1681/ASN.0000000823. Epub 2025 Sep 12.
PMID: 40938666DERIVEDZachariah T, Radhakrishnan J. Potential Role of Mineralocorticoid Receptor Antagonists in Nondiabetic Chronic Kidney Disease and Glomerular Disease. Clin J Am Soc Nephrol. 2024 Nov 1;19(11):1499-1512. doi: 10.2215/CJN.0000000000000540. Epub 2024 Jul 22.
PMID: 39037799DERIVED
MeSH Terms
Interventions
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 12, 2021
First Posted
September 17, 2021
Study Start
September 21, 2021
Primary Completion
December 31, 2025
Study Completion
February 2, 2026
Last Updated
February 13, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will not share
Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.clinicalstudydatarequest.com to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the Study sponsors section of the portal.