The Effect of Emotional Working Memory Training on Preventing Depression Occurrence

NCT04346784 | Unknown

• 1 other identifier: EMOTION2 2019
• Study Type: interventional
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test whether emotional working memory training and attention bias modification training are an effective neurobehavioral therapy to prevent the occurrence of depression .That is whether emotional working memory training and attention bias modification training are superior to placebo in preventing the occurrence of depression over 1 year after training.

Conditions

Depressive Symptoms

Keywords

Depression; Cognitive control; Emotion; Working memory; Cognitive bias; Emotional regulation

Outcome Measures

Primary Outcomes (1)

• Changes of depressive symptoms

  Depression symptoms tested by clinicians using the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS)

  pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)

Secondary Outcomes (1)

• Changes of self-reported depressive symptoms

  pre-training, post-training(2 weeks after pre-training), follow-ups(1-week,2-week,4-week,7-week,3-month( booster pre-training), 4-month (booster post-training), 5-month,6-month,12-month after post-training)

Study Arms (4)

maintaining positive working memory training

EXPERIMENTAL

Maintaining positive working memory training is based on visual positive works n-back task.In this training, positive words are presented on the pictures of happy face.According to the rules, subjects are required to identify whether the word present currently is as the same type as the word presented n before then click the keys correspondingly.Each training session contains 15 blocks which are consisted with 20+n trails.

Behavioral: maintaining positive working memory training

repressing negative working memory training

EXPERIMENTAL

Repressing negative working memory training is a dual n-back task containing visual and auditory stimulus.Both two types of stimulus are negative.In this training, subjects are required to identify whether the location of picture presented on the screen or the word appeared in the headphone is the same as the picture or the word presented n before, then react with typing correspondingly.Each training session contains 16 blocks which are consisted with 20+n trails.

Behavioral: repressing negative working memory training

Positive ABMT

EXPERIMENTAL

In the positive attention bias, there are 54 pairs of neutral-negative words, 27 pairs of which are used in the training group and 27 pairs of which are used in the placebo group. The word pairs in each group are repeated 8 times, with a total of 216 trial.Participants received 10 sessions over 2 weeks. 90% of the targets in the training group appear in the positive word position and 10% of the targets appear in the neutral word position.

Behavioral: Positive ABMT

Positive placebo ABMT

PLACEBO COMPARATOR

In the positive attention bias, there are 54 pairs of neutral-negative words, 27 pairs of which are used in the training group and 27 pairs of which are used in the placebo group. The word pairs in each group are repeated 8 times, with a total of 216 trial.Participants received 10 sessions over 2 weeks. while 90% of the targets in the placebo group appear in the neutral word position and 10% of the targets appear in the positive word position.

Behavioral: Positive placebo ABMT

Interventions

maintaining positive working memory training BEHAVIORAL

Participants complete 10 sessions of maintaining positive working memory training during a two-week period. Each session consists of 15 blocks.

maintaining positive working memory training

repressing negative working memory training BEHAVIORAL

Participants complete 10 sessions of repressing negative working memory training during a two-week period. Each session consists of 15 blocks.

repressing negative working memory training

Positive ABMT BEHAVIORAL

Participants complete 8 sessions of attention bias modification training (ABMT) during a two-week period. Each session consists of 218 trials, and the time to complete a training session is 12 minutes.

Positive ABMT

Positive placebo ABMT BEHAVIORAL

Participants complete 8 sessions of attention bias modification training (ABMT) during a two-week period. Each session consists of 218 trials, and the time to complete a training session is 12 minutes

Positive placebo ABMT

Eligibility Criteria

• Age: 16 Years - 21 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• A score of 14 or higher on the Beck Depression Inventory-II.

You may not qualify if:

• A current episode of MDD, bipolar disorder, schizophrenia or organic mental disorder;
• Any concurrent psychotherapy;
• Any concurrent psychotropic medication.

Sponsors & Collaborators

• Hunan Normal University: lead

Study Sites (1)

Department of Psychology, Hunan Normal University

Changsha, Hunan, 400081, China

Location

MeSH Terms

Conditions

Depression; Emotional Regulation

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Self-Control; Social Behavior

Study Officials

• Wenhui Yang, Ph.D

  Department of Psychology, Hunan Normal University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Psychology

Study Record Dates

• First Submitted: April 12, 2020
• First Posted: April 15, 2020
• Study Start: December 18, 2019
• Primary Completion: January 10, 2021
• Study Completion: January 10, 2021
• Last Updated: April 15, 2020

Record last verified: 2020-04

Locations

CN (1)