The Effect of Attention Bias Modification Training on Reducing Depressive Symptoms

NCT01628016 | Completed Results

• 1 other identifier: XJK011AXL002
• Study Type: interventional
• Target: 77
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test whether attention bias modification training is an effective neurobehavioral therapy to improve depressive symptoms.That is whether attention bias modification training is superior to placebo in reducing depressive symptoms over 1 year after training.

Conditions

Depressive Symptoms

Keywords

depression; attention; training; modification

Outcome Measures

Primary Outcomes (1)

• Depressive Symptoms Measured by Beck Depression Inventory-II

  Beck Depression Inventory-II(BDI-II) contains 21 items and rates the depressive symptoms for the past two weeks. Each question provides for a response of 0 to 3. A zero response means the depressive symptom is not present; a 1 means the symptom is present, a 2 means the symptom is moderate, and a 3 means the symptom is severe. The total BDI-II score is the sum of the individual items; total BDI-II scores can range from 0 to 63. Cutoff points developed by Beck, Steer, \& Brown (1997) for the total BDI-II are: 0 to 13, nondepressed; 14 to 19, mild depression; 20 to 28, moderate depression; 29 or more, severe depression.

  From the baseline to posttraining, 2-, 4-, 8-week, 3-, 7-month follow-ups after training

Secondary Outcomes (1)

• Anxiety and Rumination Symptoms Measured by State-Trait Anxiety Inventory-Trait(STAI-T) and Rumination Response Style（RRS）

  From baseline to post-training, 2-, 4-, 8-week, 3- , 7-month follow-ups after training

Study Arms (3)

Attentional bias modification training

EXPERIMENTAL

1. Attention bias modification training (ABMT) is a modified dot probe task, in which a probe always appears in the location of neutral stimulus after the two stimuli (i.e. one is the depressive cue and the other is neutral) were simultaneously presented. In the ABMT,the probability that a probe appears in the location of neutral is 90%, and correspondingly,in the location of depressive stimuli is 10%. 2. ABMT intervention: Participants complete 8 sessions of attention bias modification training (ABMT) during a two-week period. Each session consists of 218 trials, and the time to complete a training session is 12 minutes (4 sessions a week, roughly one session every other day with for each session).

Behavioral: a word dot-probe task for training procedure

Placebo training

PLACEBO COMPARATOR

Participants complete 8 sessions of placebo training(PT) during a two-week period. Placebo training is a classic dot probe task, in which a probe appears after either of the locations that the two stimuli (i.e. one is the depressive cue and the other is neutral) were presented, with the same frequencies. In the PT condition, each session also consists of 218 trials, and the time to complete a PT session is approximately 10 minutes as well.

Behavioral: a word dot-probe task for training procedure

blank control

NO INTERVENTION

Participants only complete assessment at each point time.

Interventions

a word dot-probe task for training procedure BEHAVIORAL

In the word dot-probe task for training procedure of attention bias modification, 90% of the targets appeared at the neutral word position and 10% at the sad word position.In the placebo condition, the targets appeared with equal probability in the sad (50%) and neutral (50%) word positions.All participants in ABM and placebo conditions received eight 12-min training sessions over a 2-week period.During each session, participants completed 216 word dot-probe trials.

Attentional bias modification training; Placebo training

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• A score of 14 or higher on the Beck Depression Inventory-II

You may not qualify if:

• a current episode of MDD, bipolar disorder, schizophrenia or organic mental disorder;
• any concurrent psychotherapy;
• any concurrent psychotropic medication.

Sponsors & Collaborators

• Hunan Normal University: lead

Study Sites (1)

Department of Psychology, Hunan Normal University

Changsha, Hunan, 400081, China

Location

Related Publications (1)

• Yang W, Ding Z, Dai T, Peng F, Zhang JX. Attention Bias Modification training in individuals with depressive symptoms: A randomized controlled trial. J Behav Ther Exp Psychiatry. 2015 Dec;49(Pt A):101-11. doi: 10.1016/j.jbtep.2014.08.005. Epub 2014 Sep 8.

  PMID: 25245928 DERIVED

MeSH Terms

Conditions

Depression

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Results Point of Contact

• Title: Dr. Wenhui Yang
• Organization: Hunan Normal University

yangwh110@163.com

+86 731 8873076

Study Officials

• Wenhui Yang, Ph.D

  Department of Psychology, Hunan Normal University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Psychology

Study Record Dates

• First Submitted: June 9, 2012
• First Posted: June 26, 2012
• Study Start: September 1, 2011
• Primary Completion: July 1, 2013
• Study Completion: July 1, 2013
• Last Updated: August 14, 2020
• Results First Posted: September 19, 2019

Record last verified: 2020-08

Locations

CN (1)