Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
1 other identifier
interventional
600
1 country
1
Brief Summary
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2014
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2014
CompletedFirst Submitted
Initial submission to the registry
February 28, 2020
CompletedFirst Posted
Study publicly available on registry
March 5, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2026
CompletedSeptember 10, 2025
September 1, 2025
11.6 years
February 28, 2020
September 4, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in N-Back Task
Working Memory Task
Baseline to Post-Treatment, 1 Week
Secondary Outcomes (5)
Change in Flanker Task
Baseline to Post-Treatment, 1 Week
Change in Multi-Source Interference with International Affective Picture System Task
Baseline to Post-Treatment, 1 Week
Change in Delayed Discounting Task
Baseline to Post-Treatment, 1 Week
Change in Stop Signal Task
Baseline to Post-Treatment, 1 Week
Change in Iowa Gambling Task
Baseline to Post-Treatment, 1 Week
Study Arms (8)
Traumatic Brain Injury
EXPERIMENTALThis group consists of individuals diagnosed with traumatic brain injury. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Major Depressive Disorder
EXPERIMENTALThis group consists of individuals diagnosed with major depressive disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Bipolar Disorder
EXPERIMENTALThis group consists of individuals diagnosed with bipolar disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Schizophrenia
EXPERIMENTALThis group consists of individuals diagnosed with schizophrenia. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Attention Deficit Hyperactivity Disorder
EXPERIMENTALThis group consists of individuals diagnosed with attention deficit hyperactivity disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Borderline Personality Disorder
EXPERIMENTALThis group consists of individuals diagnosed with borderline personality disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Substance Use Disorder
EXPERIMENTALThis group consists of individuals diagnosed with substance use disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Healthy Controls
ACTIVE COMPARATORThis group consists of individuals diagnosed with healthy controls. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Interventions
In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes.
Eligibility Criteria
You may qualify if:
- Male and female outpatients 18-65 years of age
- A diagnosis of traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorders meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
You may not qualify if:
- Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, shunts, pacemakers, pregnancy.
- Active substance dependence (except for tobacco and cannabis).
- Pregnant or nursing females.
- Inability to participate in testing procedures.
- Diagnosis of psychiatric of neurological disorder
- Ongoing treatment with any psychotropic medications.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Massachusetts General Hospital
Boston, Massachusetts, 02129, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Joan Camprodon, MD, PhD, MPH
Massachusetts General Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Chief of Division of Neuropsychiatry, Director of TMS Clinic, Director of Lab for Neuropsychiatry and Neuromodulation
Study Record Dates
First Submitted
February 28, 2020
First Posted
March 5, 2020
Study Start
September 1, 2014
Primary Completion
April 1, 2026
Study Completion
April 1, 2026
Last Updated
September 10, 2025
Record last verified: 2025-09