Major Depressive Disorder
1,733
185
234
1,085
Key Insights
Highlights
Success Rate
91% trial completion (above average)
Published Results
440 trials with published results (25%)
Research Maturity
1085 completed trials (63% of total)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 17/100
6.0%
104 terminated out of 1733 trials
91.3%
+4.7% vs benchmark
26%
445 trials in Phase 3/4
41%
440 of 1085 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 1085 completed trials
Clinical Trials (1733)
DBS for Depression
Natural History of Depression, Bipolar Disorder and Suicide Risk
Predictors of Treatment Outcome in Major Depressive Disorder
Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Closed-loop Optimized rTMS for Depression
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
JAK Signaling in Depression
Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)
DBS for TRD With the Medtronic Percept PC
Intradermal Acupuncture as an Adjunct to SSRI Tapering in Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Mobile Screening for Major Depressive Disorder in Adults From an Ethnically and Socioeconomically Diverse Population.
A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive Disorder
Individualized dlPFC-NAcc Modulation for Anhedonia in adMDD