Key Insights

Highlights

Success Rate

91% trial completion (above average)

Published Results

440 trials with published results (25%)

Research Maturity

1085 completed trials (63% of total)

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 17/100

Termination Rate

6.0%

104 terminated out of 1733 trials

Success Rate

91.3%

+4.7% vs benchmark

Late-Stage Pipeline

26%

445 trials in Phase 3/4

Results Transparency

41%

440 of 1085 completed with results

Key Signals

440 with results91% success104 terminated

Data Visualizations

Phase Distribution

1,522Total
Not Applicable (670)
Early P 1 (20)
P 1 (125)
P 2 (262)
P 3 (241)
P 4 (204)

Trial Status

Completed1,085
Unknown192
Recruiting185
Terminated104
Withdrawn57
Active Not Recruiting49

Trial Success Rate

91.3%

Benchmark: 86.6%

Based on 1085 completed trials

Clinical Trials (1733)

Showing 20 of 20 trials
NCT03437928Not ApplicableActive Not RecruitingPrimary

DBS for Depression

NCT06462196Recruiting

Natural History of Depression, Bipolar Disorder and Suicide Risk

NCT07853365Not Yet RecruitingPrimary

Predictors of Treatment Outcome in Major Depressive Disorder

NCT02129751Phase 4Not Yet RecruitingPrimary

Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder

NCT06050070Not ApplicableCompletedPrimary

Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback

NCT05054699Phase 2CompletedPrimary

Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study

NCT07594483Not ApplicableRecruitingPrimary

Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium

NCT04142320Phase 1CompletedPrimary

Closed-loop Optimized rTMS for Depression

NCT06564818Phase 3Active Not RecruitingPrimary

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

NCT07003997Phase 2RecruitingPrimary

JAK Signaling in Depression

NCT06979154Not ApplicableTerminated

Pilot Study of Personalized Aperiodic Transcranial Alternating Current Stimulation in Antenatal Depression (PandA-tACS)

NCT05850689Phase 3RecruitingPrimary

Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

NCT06605105Phase 3Enrolling By InvitationPrimary

Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)

NCT05773755Not ApplicableRecruitingPrimary

DBS for TRD With the Medtronic Percept PC

NCT07390981Not ApplicableNot Yet RecruitingPrimary

Intradermal Acupuncture as an Adjunct to SSRI Tapering in Major Depressive Disorder

NCT03065335Phase 1Recruiting

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

NCT00018057Phase 2Recruiting

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

NCT05989412Not ApplicableActive Not RecruitingPrimary

Mobile Screening for Major Depressive Disorder in Adults From an Ethnically and Socioeconomically Diverse Population.

NCT05376150Phase 2CompletedPrimary

A Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 in Major Depressive Disorder

NCT05544071Not ApplicableCompletedPrimary

Individualized dlPFC-NAcc Modulation for Anhedonia in adMDD

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