Effects of Transcranial Direct Current Stimulation in Individuals With Schizophrenia
1 other identifier
interventional
11
1 country
1
Brief Summary
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities and alter functional connectivity in individuals with Schizophrenia. In this research, a 9 volt battery is used to deliver very weak electrical current to the surface of the scalp while participants complete cognitive tasks. Participants also receive a brain scan before and after stimulation. Our aim is to determine if tDCS can improve mental abilities in individuals with schizophrenia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable schizophrenia
Started Jun 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 24, 2012
CompletedFirst Posted
Study publicly available on registry
May 30, 2012
CompletedStudy Start
First participant enrolled
June 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2014
CompletedSeptember 1, 2015
August 1, 2015
2.3 years
May 24, 2012
August 31, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cognitive Test Performance
Cognitive test performance by subjects will be evaluated upon completion of enrollment to determine if tDCS improved performance on cognitive tests.
The average time frame is approximately 2 hours
Secondary Outcomes (1)
Functional Connectivity Changes Associated with tDCS
Time frame is approximately 2 hours
Study Arms (3)
Anodal Stimulation
EXPERIMENTALtranscranial direct current stimulation using Anodal stimulation over the area of interest
Cathodal
EXPERIMENTALtranscranial direct current stimulation using cathodal stimulation over the brain area of interest
Sham Stimulation
SHAM COMPARATORtranscranial direct current stimulation that is ramped up and ramped down providing the sensation of tDCS without actually delivering tDCS
Interventions
delivery of transcranial direct current stimulation or sham for 20 to 60 minutes
Eligibility Criteria
You may qualify if:
- Diagnosis of Schizophrenia
- English as a native language
You may not qualify if:
- appreciable deficits in hearing or vision
- appreciable accent
- any implanted metal device or pacemaker
- Dementia or Mini Mental Exam below 24
- History of Seizures
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Neurology
Baltimore, Maryland, 21231, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Barry Gordon
Johns Hopkins University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Editor-in-Chief, Cognitive and Behavioral Neurology/Therapeutic Cognitive Neuroscience Professor/Professor of Neurology and Cognitive Science
Study Record Dates
First Submitted
May 24, 2012
First Posted
May 30, 2012
Study Start
June 1, 2012
Primary Completion
September 1, 2014
Study Completion
September 1, 2014
Last Updated
September 1, 2015
Record last verified: 2015-08