Differences in Rate of Recovery Between Young and Middle-aged Men After Downhill Running

NCT04025723 | Completed

• 1 other identifier: Recovery
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate differences in rate of recovery between young and middle-aged men after prolonged (downhill) running. Thirty healthy young (n=15, 18-30 y) and middle-aged (n=15, 35-50y) men will be recruited for this study. Participants will perform 60 minutes of downhill run at 65% of their maximal oxygen consumption (VO2max). Recovery parameters will be evaluated during 48 hours following the downhill protocol, and will include changes in performance tests, inflammatory markers, muscle integrity and heart-rate variability. Questioners will be used to evaluate muscle soreness and fatigue. We hypothesized that middle-aged males will have longer rate of recovery following the downhill running protocol, as compared to younger age males.

Conditions

Exercise

Outcome Measures

Primary Outcomes (4)

• Changes over time in Maximal voluntary contraction (MVC) of the Musculus quadriceps femoris

  MVC (kg) measures the greatest amount of tension a muscle can generate and hold. We will measure it before (baseline) and after the downhill running protocol. Changes from baseline will be calculated for each time point. A comparison of the changes in MVC over time will be made between the two study's arms .

  MVC will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

• Changes over time in vertical jump (VJ)

  VJ (cm) is the height achieved after a vertical jump.We will measure it before (baseline) and after the downhill running protocol. Changes from baseline will be calculated for each time point. A comparison of the changes in VJ over time will be made between the two study's arms .

  VJ will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

• Changes over time in stride length

  Stride length (cm) is the distance achieved while walking or running and is calculated as the distance from the toe of your right foot (starting position) to the toe of your right foot (ending position). Participants will run on a treadmill with pressure sensors for 2 minutes. We will measure stride length before (baseline) and after the downhill running protocol. Changes from baseline will be calculated for each time point. A comparison of the changes in stride length over time will be made between the two study's arms .

  Stride length will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

• Changes over time in stride frequency

  Stride frequency (strides per minutes) is the number of times a single foot hits the ground while walking or running. Participants will run on a treadmill with pressure sensors for 2 minutes. We will measure stride frequency before (baseline) and after the downhill running protocol. Changes from baseline will be calculated for each time point. A comparison of the changes in stride frequency over time will be made between the two study's arms .

  Stride frequency will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

Secondary Outcomes (13)

• Changes over time in the concentration of circulating interleukin -6 (IL-6)

  The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

• Changes over time in the concentration of circulating interleukin -10 (IL-10)

  The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

• Changes over time in the concentration of circulating interleukin -1 receptor antagonist (IL-1ra)

  The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

• Changes over time in the concentration of circulating tumor necrosis factor alpha (TNFa)

  The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

• Changes over time in the concentration of circulating c-reactive protein (CRP)

  The circulating parameters will be measured before and after 30, 60, 120 minutes (Day 0), 24 (Day 1) and 48 hours (Day 2) after the downhill running

Study Arms (2)

Young

ACTIVE COMPARATOR

men aged between 18 to 30 years old

Other: Downhill running

Middle-aged

ACTIVE COMPARATOR

men aged between 35 to 50 years old

Other: Downhill running

Interventions

Downhill running OTHER

60 minutes downhill running in 10% grade, in an effort of 65% of VO2max.

Middle-aged; Young

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Active man which perform a minimum of 150 minutes/week of exercise
• Able to complete 60 min run.

You may not qualify if:

• Injuries in lower body
• cardio-respiratory disease
• supplementing with performance enhancing supplements

Sponsors & Collaborators

• Gepner Yftach: lead

Study Sites (1)

Tel Aviv University

Tel Aviv, Israel

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Young (18-30 y) and middle aged (35-50 y) men will perform 60 min of downhill running

Study Record Dates

• First Submitted: July 9, 2019
• First Posted: July 19, 2019
• Study Start: February 20, 2020
• Primary Completion: January 16, 2021
• Study Completion: January 16, 2021
• Last Updated: March 25, 2021

Record last verified: 2021-03

Locations

IL (1)