Autonomical and Hemodynamic Repercussions on Excentric Resistance in Different Intensities With Blood Flow Restriction

NCT03942510 | Completed

• 1 other identifier: U1111-1232-0808
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Studies on resistance training (RT) associated with blood flow restriction (BFR) have emerged as an alternative method of gaining strength and hypertrophy; however, the cardiovascular and autonomic repercussion of BFR at different intensities is unknown. Thus, it becomes relevant to investigate this type of training in post-exercise. Objective: investigate and compare autonomic and hemodynamic responses of acute eccentric RT with different intensities associated or not to BFR in healthy youngsters. Method: This is a randomized clinical trial including 60 healthy men aged 18-35 years, divided into four groups according to exercise intensity and BFR: 80% without BFR, 40% without BFR, 80% with BFR and 40% with BFR. Exercise intensity will be determined by the peak of excentric torque on the dinamometer isokinetic method and by the BFR, as being 40% of the intensity required for the complete examination of the blood flow evaluated by Doppler. Participants will do an eccentric femoral quadriceps muscle exercise session on the isokinetic dynamometer according to the previously randomized group. For recovery analyzes, the recovery heart rate (HRR) in the 1st (HRR1) and 2nd (HRR2) minute, rMSSD of 30 seconds, the hemodynamic parameters (heart rate, systolic and diastolic blood pressure, respiratory rate, peripheral oxygen saturation and rate pressure product) and heart rate variability (HRV) indices analyzed in the time domain (mean HR, rMSSD and SDNN), frequency domain (LF and HF \[nu and ms2\]) and Poincaré plot (SD1 and SD2). The analysis will be occur on baseline, immediately e after the excentric exercise and in the post exercise period for 60 minutes. Descriptive statistics method and comparison of HRV indices and hemodynamic parameters between moments and groups will be performed with the aid of the analysis of variance technique for the repetitive measures model without the schema of two sets of tests to follow . The level of significance will be p \<0.05.

Conditions

Exercise

Keywords

resistance training; vascular occlusion; hemodynamics, cardiovascular system; autonomic nervous system; heart rate; recovery of physiological function

Outcome Measures

Primary Outcomes (5)

• heart rate variability indices in the time domain

  mean HR, rMSSD and SDNN in ms

  Change from baseline at 3rd week and 6rd week

• heart rate variability indices analyzed in the Poincaré plot

  SD1 and SD2 in ms

  Change from baseline at 3rd week and 6rd week

• heart rate variability indices in the frequency domain

  LF and HF in nu and ms2

  Change from baseline at 3rd week and 6rd week

• vagal reentry

  rMSSD of 30 seconds in ms

  Change from 1 day at 10 day and 18 day

• heart rate recovery

  the recovery heart rate (HRR) in the 1st (HRR1) and 2st (HRR2) minute \[bpm\]

  Change from 1 day at 10 day and 18 day

Secondary Outcomes (4)

• hemodynamic parameter

  through study completion, an average of 6 weeks

• hemodynamic parameter

  through study completion, an average of 6 weeks

• hemodynamic parameter

  through study completion, an average of 6 weeks

• hemodynamic parameter

  through study completion, an average of 6 weeks

Study Arms (4)

High intensity eccentric training

EXPERIMENTAL

high intensity (80% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.

Other: eccentric exercise with blood flow restriction

High intensity eccentric training with blood flow restriction

EXPERIMENTAL

high intensity (80% isometric peak) eccentric training of the knee extensors in the isokinetic associated with a pressure cuff placed in the proximal thigh (40% of absolute occlusion pressure) will be performed during 6 weeks, 3 times a week.

Other: eccentric exercise with blood flow restriction

Low intensity eccentric training

EXPERIMENTAL

A low intensity (40% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.

Other: eccentric exercise with blood flow restriction

Low intensity eccentric training with blood flow restriction

EXPERIMENTAL

A low intensity (40% isometric peak) eccentric training of the knee extensors in the isokinetic associated with a pressure cuff placed in the proximal thigh (40% of absolute occlusion pressure)will be performed during 6 weeks, 3 times a week.

Other: eccentric exercise with blood flow restriction

Interventions

eccentric exercise with blood flow restriction OTHER

High/low intensity eccentric training group (80% and 40% of isometric peak torque) with or not blood flow restriction.

High intensity eccentric training; High intensity eccentric training with blood flow restriction; Low intensity eccentric training; Low intensity eccentric training with blood flow restriction

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• male sex;
• healthy;
• aged between 18 and 35 years

You may not qualify if:

• smokers;
• alcoholics;
• use drugs that influenced cardiac autonomic activity;
• cardiovascular, metabolic or endocrine diseases.

Sponsors & Collaborators

• Paulista University: lead

Study Sites (1)

Leonardo Kesrouani Lemos

Presidente Prudente, São Paulo, 19050-050, Brazil

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Franciele M Vanderlei, PhD

  Paulista State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 30, 2019
• First Posted: May 8, 2019
• Study Start: March 11, 2019
• Primary Completion: October 17, 2019
• Study Completion: December 22, 2020
• Last Updated: March 9, 2021

Record last verified: 2021-03

Locations

BR (1)