Effects of Low Intensity, High Intensity Eccentric Resistance Training Associated With Blood Flow Restriction

NCT03601104 | Completed DMC

• 1 other identifier: 680075683140
• Study Type: interventional
• Target: 61
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: studies on resistance training of low intensity associated with blood flow restriction in recent years, although there are still gaps that can be explored in relation to their physiological phenomena when associated with eccentric training. In this way, from there the exploration becomes relevant the investigation of eccentric training associated to an RFS. Objective: To analyze and compare the effects of a high intensity and low intensity intensive resistance training associated with an RFS (TREAI-RFS and TREBI-RFS) with a high intensity eccentric resistance training without RFS (TREAI) in knee extensors. Method: The study will consist of 45 male participants, allocated from a stratified randomization into three groups: TREAI (n = 15), TREAI-RFS (n = 15) and TREBI-RFS (n = 15). Participants underwent a training program with a minimum of 40% without RFS, 80% with RFS and 40% with CVS of CVIM, 3 times a week, and the outcomes of muscle strength, muscle structure, power test and Endothelial growth will be assessed one week before, the fourth week and one week after the end of the training program. In addition, clinical markers of perception and recovery effort are investigated before and after a session. The graph used is descriptive and descriptive, as it is used as a model of analysis of variance for the analysis of replications without a two-factor scheme, which provides detailed information on how the measures are repeated, neither. A whole statistical analysis can reach the level of significance of 5%.

Conditions

Exercise

Keywords

Eccentric Training; Resistance Training

Outcome Measures

Primary Outcomes (4)

• Change in muscle strength torque peaks at dinamometer isokinetic

  The isometric, eccentric and concentric torque peaks will be measured with an isokinetic dynamometer in order to evaluate the adaptations of knee extensor force to eccentric training.

  baseline, fourth week and one week after sixth week

• Change in muscular structure with ultrasonography

  Ultrasonographic imaging of the dominant lower limb will be captured to determine muscle thickness of the vastus lateralis (VL) and rectus femoris (RF) muscles.

  baseline, fourth week and one week after sixth week.

• Change in Vascular Endothelial Growth Factor (VEGF)

  For the analysis of the concentration of endothelial growth factor (VEGF) will be collected 10 ml of blood sample. The plasma of this sample will be stored at -80 ° C for further analysis.

  baseline, fourth week and one week after sixth week.

• Change in muscle power test

  The strength and muscle power tests will be performed on a vertical squat with a guided bar.

  baseline, fourth week and one week after sixth week.

Secondary Outcomes (4)

• Pain threshold

  Assessed at baseline, 4th week, and 6th week.

• Analog Visual Scale

  Assessed at baseline, 4th week, and 6th week.

• Perceived Effort Scale (Borg)

  Assessed at baseline, 4th week, and 6th week.

• Recovery Perception Scale

  Assessed at baseline, 4th week, and 6th week.

Study Arms (4)

HIET (n = 15)

ACTIVE COMPARATOR

High intensity eccentric training: A high intensity (80% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.

Other: High intensity eccentric training

HIET-BFR (n= 15)

EXPERIMENTAL

High intensity eccentric training with blood flow restriction (BFR): A high intensity eccentric (80% isometric peak) training of the knee extensors in isokinetic will be performed, associated with a pressure cuff placed in the proximal thigh (40% of absolute occlusion pressure) for 6 weeks, 3 times a week.

Other: High intensity eccentric training with BFR

LIET-BFR (n = 15)

EXPERIMENTAL

Low intensity eccentric training with blood flow restriction (BFR): A low intensity eccentric (40% isometric peak) training of the knee extensors in isokinetic will be performed associated with a pressure cuff placed in the proximal thigh (40% absolute occlusion pressure) for 6 weeks, 3 times a week.

Other: Low intensity eccentric training with BFR

LIET (n= 15)

ACTIVE COMPARATOR

Low intensity eccentric training: A low intensity (40% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.

Other: Low intensity eccentric training

Interventions

High intensity eccentric training OTHER

High intensity eccentric training group with 80% of isometric peak torque.

HIET (n = 15)

High intensity eccentric training with BFR OTHER

Eccentric high intensity training group with 80% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).

HIET-BFR (n= 15)

Low intensity eccentric training with BFR OTHER

Low intensity eccentric training group with 40% of isometric peak torque associated with blood flow restriction (40% of absolute occlusion pressure).

LIET-BFR (n = 15)

Low intensity eccentric training OTHER

Low intensity eccentric training group with 40% of isometric peak torque

LIET (n= 15)

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• male sex;
• healthy;
• aged between 18 and 35 years

You may not qualify if:

• smokers;
• alcoholics;
• use drugs that influenced cardiac autonomic activity;
• cardiovascular, metabolic or endocrine diseases.

Sponsors & Collaborators

• Paulista University: lead

Study Sites (1)

Franciele Marques Vanderlei

Presidente Prudente, São Paulo, 55, Brazil

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Franciele Marques Vanderlei, PhD

  Universidade Estadual Paulista - FCT / UNESP

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: June 21, 2018
• First Posted: July 26, 2018
• Study Start: March 12, 2019
• Primary Completion: May 12, 2019
• Study Completion: December 31, 2020
• Last Updated: March 9, 2021

Record last verified: 2021-03

Locations

BR (1)