Carbohydrate Feeding Frequency, Muscle Glycogen and Exercise Capacity in Runners

NCT03749785 | Completed

• 1 other identifier: 18/SW/0177
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the effects of regular sucrose feeds compared to a single large bolus given late in exercise, on muscle glycogen utilisation, exercise capacity and other markers of metabolism during running

Conditions

Exercise

Outcome Measures

Primary Outcomes (2)

• Muscle glycogen concentrations

  Muscle glycogen concentration at rest, after 75 minutes of treadmill running and at volitional exhaustion. Measured using the bergstrom needle technique for obtaining muscle biopsy samples

  Estimated to be between 90 and 145 minutes

• Exercise capacity

  Time to exhaustion at the pre-determined speed to elicit exhaustion after \~90 minutes when ingesting water only

  Estimated to be between 90 and 145 minutes

Secondary Outcomes (9)

• Ratings of perceived exertion

  Estimated to be between 90 and 145 minutes

• Ratings of stomach discomfort

  Estimated to be between 90 and 145 minutes

• Carbohydrate oxidation

  Estimated to be between 90 and 145 minutes

• Fat oxidation

  Estimated to be between 90 and 145 minutes

• Plasma glucose concentrations

  Estimated to be between 90 and 145 minutes

Study Arms (2)

Regular carbohydrate feeding

ACTIVE COMPARATOR

Ingestion of 75 g sucrose, given in regular doses for the first 75 minutes of exercise during a time to exhaustion run

Other: Regular carbohydrate feeding

Single carbohydrate bolus

ACTIVE COMPARATOR

Ingestion of 75 g sucrose, given in a single bolus after 75 minutes of exercise, during a time to exhaustion run

Other: Single carbohydrate bolus

Interventions

Regular carbohydrate feeding OTHER

60 ml of water with 5 g sucrose given every 5 minutes 14 times up until 70 minutes followed by 5 g sucrose after 75 minutes in a 250 ml solution

Regular carbohydrate feeding

Single carbohydrate bolus OTHER

60 ml of water given every 5 minutes 14 times up until 70 minutes followed by 75 g sucrose after 75 minutes in a 250 ml solution

Single carbohydrate bolus

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Self-identify as a trained runner
• Regularly participate in running activity (\>2 times a week)
• Participated in running based training for a minimum of 2 years
• Be willing to undertake exercise sessions until volitional exhaustion
• Be willing to have the necessary samples taken during the testing protocols
• Not a habitual smoker
• Have the capacity and willingness to provide informed consent (oral and written)
• Successful completion of the physical activity readiness questionnaire (PAR-Q)

You may not qualify if:

• Female
• \<18 or \>50 years old
• Not regularly participating in running activity (\<3 times a week)
• Experience contraindications to the administration of the proposed anaesthetic (Lidocaine Hydrochloride)
• Habitual/previously habitual smoker

Sponsors & Collaborators

• University of Bath: lead

Study Sites (1)

Department for Health, University of Bath

Bath, BA2 7AY, United Kingdom

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Department for Health

Study Record Dates

• First Submitted: November 19, 2018
• First Posted: November 21, 2018
• Study Start: October 14, 2018
• Primary Completion: March 20, 2019
• Study Completion: April 16, 2019
• Last Updated: November 1, 2019

Record last verified: 2019-03

Locations

GB (1)