Galactose Mediated Glycogen Resynthesis

NCT03903861 | Completed

• 1 other identifier: ERN_19-0308
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.

Conditions

Exercise

Outcome Measures

Primary Outcomes (1)

• Muscle glycogen synthesis rates (mmol/kg/dm/h)

  Muscle glycogen synthesis rates over the post-exercise recovery period

  4 hours

Secondary Outcomes (9)

• Carbohydrate oxidation rates (g/min)

  Up to 90 minutes

• Fat oxidation rates (g/min)

  Up to 90 minutes

• Plasma glucose (mmol/L)

  Up to 6 hours

• Serum insulin (mU/L)

  Up to 6 hours

• Plasma galactose (mmol/L)

  Up to 6 hours

Study Arms (3)

Glucose alone

EXPERIMENTAL

Participants will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.

Other: Glucose alone

Galactose alone

EXPERIMENTAL

Participants will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.

Other: Galactose alone

Glucose and galactose

EXPERIMENTAL

Participants will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.

Other: Glucose and galactose

Interventions

Glucose alone OTHER

Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.

Glucose alone

Galactose alone OTHER

Young men or women will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.

Galactose alone

Glucose and galactose OTHER

Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.

Glucose and galactose

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index in the range: 18.5 - 27.5 kg/m2
• Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week
• Aerobic fitness: VO2max \>45 ml/kg/min (men), \>40 ml/kg/min (women)

You may not qualify if:

• Lidocaine allergy
• Current participation in another scientific/clinical study
• Bleeding disorder/s
• Current or recent smoker to include vaping (last 60 days)
• Vegan
• Existence of food intolerances
• Poor recent health as indicated in the general health questionnaire
• Engage in uncommon eating practices (e.g. sustained periods of fasting)
• Diagnosed with galactosemia

Sponsors & Collaborators

• University of Birmingham: lead
• Dairy Management Inc.: collaborator

Study Sites (1)

School of Sport, Exercise and Rehabilitation Sciences

Birmingham, West Midlands, B15 2TT, United Kingdom

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Glucose; Galactose

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Gareth Wallis, PhD

  University of Birmingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 29, 2019
• First Posted: April 4, 2019
• Study Start: July 1, 2019
• Primary Completion: May 1, 2020
• Study Completion: May 1, 2020
• Last Updated: January 4, 2023

Record last verified: 2022-12

Locations

GB (1)