The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size.

NCT03983070 | Completed

• 1 other identifier: 491
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Blood-flow restriction training (BFR) is a technique utilized to provide the benefits of high intensity exercise (strength, power, hypertrophy) when applied to exercise intensities that are insufficient to produce these benefits without BFR. The technique involves the application of an occlusive cuff (similar in design to a blood pressure cuff) over the limb of an individual that is set to occlude arterial blood flow at a given percentage during exercise. BFR has demonstrated increased strength and muscle hypertrophy compared to control interventions in various populations including: healthy subjects, athletes, post-surgery, clinical rehabilitation, and older adults. Most research on BFR has been conducted on single joint exercises and not exercises that exhibit more complex movements typically associated with daily activities. The early evidence of complex exercises combined with BFR suggests that strength and hypertrophy both improve, however more research needs to be conducted. The purpose of this project is to determine if four weeks of BFR training combined with approach rowing and deadlifts increases strength, power, aerobic capacity, and muscle size. These results will be compared to an isovolumetric control.

Conditions

Healthy

Keywords

Strength; Hypertrophy; Oxygen consumption

Outcome Measures

Primary Outcomes (1)

• Change in Muscle Size after 4 weeks

  Cross-sectional measurement of muscle girth

  after 4 weeks of intervention

Secondary Outcomes (2)

• Change in Maximal Oxygen Consumption after 4 weeks

  after 4 weeks of intervention

• Change in Maximal Deadlift Strength after 4 weeks

  after 4 weeks of intervention

Other Outcomes (5)

• Change in Numeric Pain Rating after 4 weeks

  after 4 weeks of intervention

• Change in International Physical Activity Questionnaire - Short Form after 4 weeks

  after 4 weeks of intervention

• Change in Resting Heart Rate after 4 weeks

  after 4 weeks of intervention

Study Arms (2)

Control Exercise Group

ACTIVE COMPARATOR

Participants allocated to the Control Exercise Group will participate in 8 total exercise sessions (2x per week for 4 weeks). Exercise sessions will include two exercise modalities 1)seated rowing ergometer and 2) dumbbell deadlifts. Exercise intensity will be individualized based upon preliminary testing with rowing at 80% maximal Watts, and deadlifts at 60% of one-repetition maximum.

Other: Seated Rowing Ergometer; Other: Deadlift

Blood Flow Restriction and Exercise Group

EXPERIMENTAL

Participants allocated to the Control Exercise Group will participate in 8 total exercise sessions (2x per week for 4 weeks). Exercise sessions will include the application of blood flow restriction during two exercise modalities 1)seated rowing ergometer and 2) dumbbell deadlifts. Exercise intensity will be individualized based upon preliminary testing with rowing at 40% maximal Watts, and deadlifts at 30% of one-repetition maximum. Blow flow restriction will be applied at 80% occlusion during both exercise modalities.

Other: Seated Rowing Ergometer; Other: Deadlift; Other: Blood flow restriction

Interventions

Seated Rowing Ergometer OTHER

Seated rowing exercise performed at a specific percentage of maximal Watts according to pre-intervention measures

Blood Flow Restriction and Exercise Group; Control Exercise Group

Deadlift OTHER

Deadlift exercise performed with a set of dumbbell weights at a sepcific percentage of pre-intervention one-repetition maximum.

Blood Flow Restriction and Exercise Group; Control Exercise Group

Blood flow restriction OTHER

An occlusive cuff will be placed around each proximal thigh and inflated to 80% arterial occlusion during exercise sessions.

Blood Flow Restriction and Exercise Group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Recreationally active adults (3 mo more days of moderate intensity physical activity per week, with at least some combination of aerobic and strength training).

You may not qualify if:

• Failure to achieve clearance for exercise participation via the Par-Q+ screening tool
• Currently pregnant or with 3 months post-partum
• Presence of chronic low back pain
• history of surgery to change the structure of joints within the lower extremity (joint replacement, osteotomy)
• Known blood clotting disorder or taking blood thinner medications
• Presence of peripheral vascular disease
• Presence of systemic or widespread pain disorder (fibromyalgia, chronic regional pain syndrome)
• Currently under activity limitations for any reason

Sponsors & Collaborators

• Campbell University, Incorporated: lead

Study Sites (1)

Campbell University

Buies Creek, North Carolina, 27546, United States

Location

MeSH Terms

Conditions

Hypertrophy

Interventions

Blood Flow Restriction Therapy

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities

Study Officials

• Bradley J Myers, DPT, DSc

  Campbell University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Blinded researcher will perform preliminary and outcomes measures.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Randomized clinical trial with parallel groups

Study Record Dates

• First Submitted: May 31, 2019
• First Posted: June 12, 2019
• Study Start: June 1, 2019
• Primary Completion: January 1, 2021
• Study Completion: January 1, 2021
• Last Updated: March 14, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)