NCT03973060

Brief Summary

In the field of sports training and recovery, the work of muscular strength has become the star theme in terms of its influence on the performance of athletes. In fact, in relation to the training of the inferior members, the scientific evidence indicates that, to increase the other two physical qualities conditioned (speed and resistance), it is necessary to work and to increase the muscular strength. Randomized intervention trial with sample size of 80 subjects divided into 4 groups (n = 20) of muscular work: concentric, eccentric, concentric-eccentric and isometric. Ages between 21-23 years. For all the above, the investigators will study as a main objective analyze what type of muscular work is most effective in order to improve some variables of the performance of explosive muscular strength, and to try to determine if that improvement is due, exclusively to the developed training or to the genetics of the subjects and compare the results obtained in the variables of vertical jump, power of saint, horizontal jump and speed 60 meters, before and after the execution of each one of the muscular works dynamic among themselves, and compared to the muscular work isometric.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2015

Typical duration for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2015

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2017

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 12, 2017

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

May 28, 2019

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 4, 2019

Completed
Last Updated

June 4, 2019

Status Verified

June 1, 2019

Enrollment Period

1.3 years

First QC Date

May 28, 2019

Last Update Submit

June 1, 2019

Conditions

Keywords

Jump testGenetic polymorphismMuscle strengthPhysiotherapies techniques

Outcome Measures

Primary Outcomes (4)

  • Jump power

    Mechanical power in jump tests were measured by estimated (indirect way) from a subject's jump height and body mass, by means of Sayers equation.

    Changes from baseline and at the end of procedure (12 days)

  • Vertical jump

    The protocol followed for the measurement was; First time: When the patient was barefoot, he placed himself sideways to a smooth wall and raised his right arm with his hand flat on the wall; The distance from the ground to the third finger of the hand (H1) was then measured. Second time: The subject was impregnated the third finger of the right hand in blue chalk powder, separated 10 centimeters from the wall and made a jump back movement with freedom to flex the lower limbs to the 90 º and move the arms, to consecutively and without any pause make a maximum vertical jump. Subsequently, this new distance was measured. This jump was made three times with a break between jump and jump of 45 seconds, and the average of the three (H2) was obtained. Third time: The value of the vertical jump was H = h1-h2.

    Changes from baseline and at the end of procedure (12 days)

  • Horizontal jump

    On a smooth and horizontal surface, different marks were made distanced one meter each. In the first mark the subject was placed with the feet slightly separated at the height of the hips. Then a first test jump was made; To do so, the subject was told to swing with his arms and bending his knees, he had to jump forward with the greatest possible power. Once this first Test jump was made, the second measurement was carried out, the result of which was taken into account. This result was obtained in centimeters by means of measuring tape, with a precision of one millimeter (mm), and having as points of reference the first mark and the heel of the foot more retarded. The jump was not valid if the first mark was exceeded with the feet before taking off from the ground.

    Changes from baseline and at the end of procedure (12 days)

  • 60 meters sprint

    On an unobstructed sand surface, a distance of 60 meters was pointed out. The measurement in seconds of this variable was obtained by means of a stopwatch.

    Changes from baseline and at the end of procedure (12 days)

Secondary Outcomes (2)

  • ACTN3 polymorphism

    Baseline.

  • ACE polymorphism

    Baseline.

Other Outcomes (2)

  • Cardiac frequency

    Changes from baseline and at the end of procedure (12 days).

  • Systolic and Diastolic blood pressure

    Changes from baseline and at the end of procedure (12 days).

Study Arms (4)

Concentric muscular work

EXPERIMENTAL

4 series of 12 repetitions of concentric muscular work, with one minute rest between each repetitions, total working time of 24 minutes.

Device: Concentric-eccentric muscular workGenetic: Genetic polymorphism

Eccentric muscular work

EXPERIMENTAL

4 series of 12 repetitions of eccentric muscular work, with one minute rest between each repetitions, total working time of 24 minutes.

Device: Concentric-eccentric muscular workGenetic: Genetic polymorphism

Concentric-eccentric muscular work

EXPERIMENTAL

4 series of 12 repetitions of concentric-eccentric muscular work, with one minute rest between each repetitions, total working time of 24 minutes.

Device: Concentric-eccentric muscular workGenetic: Genetic polymorphism

Isometric muscular work

EXPERIMENTAL

6 seconds of contraction, with 20 seconds of rest with 24 repetitions, for a total working time of 12 minutes.

Device: Concentric-eccentric muscular workGenetic: Genetic polymorphism

Interventions

For muscular contraction, the physiotherapist carried out 12 repetitions with one minute rest between series and series, total working time of 12 minutes.

Also known as: Muscular work, Vertical jump, 60m sprint, Jump potence, Horizontal jump
Concentric muscular workConcentric-eccentric muscular workEccentric muscular workIsometric muscular work

Genetic polymorphism study by Polymerase Chain Reaction (PCR) to determine whether the genetic makeup of individuals for the improvement of muscular work in the results of the study.

Also known as: ACTN3 gene, ACE gene
Concentric muscular workConcentric-eccentric muscular workEccentric muscular workIsometric muscular work

Eligibility Criteria

Age21 Years - 23 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Subjects that did not present musculoskeletal lesions in the lower train at the time of the study.
  • Subjects that showed a serious commitment to perform the entire muscle training.
  • Subjects not subject to another type of training plan that could interfere with the results obtained from the measurement of the study variables.

You may not qualify if:

  • Subjects with high blood pressure.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Interventions

Polymorphism, GeneticDipeptidyl-Peptidases and Tripeptidyl-Peptidases

Intervention Hierarchy (Ancestors)

Genetic VariationGenetic PhenomenaExopeptidasesPeptide HydrolasesHydrolasesEnzymesEnzymes and Coenzymes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Masking Details
The participant was blinded not knowing the treatment to which he was submitted and outcome assessor responsible for collecting the results, without commenting on the group from which the patient came. Only the principal investigator knew the group to which the patient belonged.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research Unit Director

Study Record Dates

First Submitted

May 28, 2019

First Posted

June 4, 2019

Study Start

October 1, 2015

Primary Completion

February 1, 2017

Study Completion

July 12, 2017

Last Updated

June 4, 2019

Record last verified: 2019-06