NCT02884193

Brief Summary

Cryotherapy has a wide range of clinical applications in rehabilitation, used for activities such as controlling inflammation, pain control or management of edema after an injury or surgery. In the field of cryotherapy they studied cold neuromuscular responses, where it has shown a decrease in nerve conduction velocity, which leads to a decrease in muscle strength. However it has been described in some work applications brief cold ("Quick Icing") may be opposite to those described effects, increasing the strength, the time of intervention the most important and decisive in these possible improvements or decreases factor. This effect is observed in response to a few seconds of application of cold, and would be given by an increased activity of motor neurons. Assess the influence of rapid cooling application ("Technique Quick Icing") and prolonged cooling in handgrip strength when performing a manual dynamometer test in college students.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
114

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2019

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 10, 2016

Completed
20 days until next milestone

First Posted

Study publicly available on registry

August 30, 2016

Completed
2.7 years until next milestone

Study Start

First participant enrolled

April 30, 2019

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 12, 2019

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 20, 2020

Completed
Last Updated

April 3, 2020

Status Verified

February 1, 2020

Enrollment Period

7 months

First QC Date

August 10, 2016

Last Update Submit

April 2, 2020

Conditions

Muscle Strength

Keywords

CoolingCryotherapyisometric StrengthPalmar GripDynamometry

Outcome Measures

Primary Outcomes (1)

  • Comparing maximum grip strength pre and post application of cold.

    Force in kilograms evaluated through manual dynamometry test the time for a grip.

    Baseline and 2 hours later (1 session of treatment)

Study Arms (3)

Brief Cooling (Quick Icing)

EXPERIMENTAL

Group receiving the application of cold on the ventral side of the dominant forearm for 30 seconds, using the technique of ice beakers dynamically.

Procedure: Brief Cooling

Prolonged Cold

ACTIVE COMPARATOR

Group receiving the intervention of "ice bag" for a period of 5 and a half minutes from 1 minute, on the ventral side of the dominant forearm

Procedure: Prolonged Cold

Control

SHAM COMPARATOR

Group receives a placebo application through an "ice bag" empty. The bag will be applied from 1 minute to 6 and a half minutes, as the group of prolonged cold

Procedure: Sham Ice Bag

Interventions

Brief CoolingPROCEDURE

Brief Application of cold, for a period of up to 30 seconds on a body surface which seeks to promote the activation of the nervous system to produce increased excitability.

Also known as: Quick Icing
Brief Cooling (Quick Icing)
Prolonged ColdPROCEDURE

Prolonged application of cold, for at least 5 minutes or more, on a body surface that aims to reduce nervous system activation by reducing the NCV.

Prolonged Cold
Sham Ice BagPROCEDURE

Placebo application through an "ice bag" empty.

Control

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Students of the Faculty of Rehabilitation Sciences University Andres Bello.
  • Over 18 years.
  • No skeletal muscle pathologies of the dominant upper extremity in the last 6 months.

You may not qualify if:

  • Presence of pain or discomfort in the grip.
  • Cold intolerance.
  • Pathologies as cryoglobulinemia, Raynaud's disease or paroxysmal cold hemoglobinuria.
  • Rheumatoid diseases such as systemic lupus erythematosus, multiple myeloma or arthritis Reumtoide.
  • Adverse ice cube test (test positive) reactions.
  • Osteosynthesis materials or stent in the dominant upper limb.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universidad Andrés Bello

Santiago, Comuna Las Condes, 7550000, Chile

Location

Related Publications (13)

  • Lewis M, Clayfield J. Temperature changes following quick icing: a brief investigation. Aust J Physiother. 1981 Dec;27(6):175-8. doi: 10.1016/S0004-9514(14)60756-X.

    PMID: 25025468BACKGROUND

  • Watanabe T, Owashi K, Kanauchi Y, Mura N, Takahara M, Ogino T. The short-term reliability of grip strength measurement and the effects of posture and grip span. J Hand Surg Am. 2005 May;30(3):603-9. doi: 10.1016/j.jhsa.2004.12.007.

    PMID: 15925174BACKGROUND

  • O'Driscoll SW, Horii E, Ness R, Cahalan TD, Richards RR, An KN. The relationship between wrist position, grasp size, and grip strength. J Hand Surg Am. 1992 Jan;17(1):169-77. doi: 10.1016/0363-5023(92)90136-d.

    PMID: 1538102BACKGROUND

  • Boyer J, Fraser J, Doyle A. The hemodynamic effect of cold inmersion, Clin Sci 19:539-543, 1980.

    BACKGROUND

  • Goff B. The application of recent advances in neurophysiology to Miss M. Rood's concept of neuromuscular facilitation. Physiotherapy. 1972 Dec 10;58(12):409-15. No abstract available.

    PMID: 4668364BACKGROUND

  • Krumhansl BR. Ice lollies for ice massage. Phys Ther. 1969 Oct;49(10):1098. doi: 10.1093/ptj/49.10.1098. No abstract available.

    PMID: 5343549BACKGROUND

  • Knutsson E. Topical cryotherapy in spasticity. Scand J Rehabil Med. 1970;2(4):159-63. No abstract available.

    PMID: 5523762BACKGROUND

  • Oliver RA, Johnson DJ, Wheelhouse WW, Griffin PP. Isometric muscle contraction response during recovery from reduced intramuscular temperature. Arch Phys Med Rehabil. 1979 Mar;60(3):126-9.

    PMID: 485802BACKGROUND

  • Lee JM, Warren MP, Mason SM. Effects of ice on nerve conduction velocity. Physiotherapy. 1978 Jan;64(1):2-6. No abstract available.

    PMID: 628689BACKGROUND

  • CLARKE RS, HELLON RF, LIND AR. Vascular reactions of the human forearm to cold. Clin Sci. 1958 Feb;17(1):165-79. No abstract available.

    PMID: 13511729BACKGROUND

  • McGown HL. Effects of cold application on maximal isometric contraction. Phys Ther. 1967 Mar;47(3):185-92. doi: 10.1093/ptj/47.3.185. No abstract available.

    PMID: 6042350BACKGROUND

  • Belitsky RB, Odam SJ, Hubley-Kozey C. Evaluation of the effectiveness of wet ice, dry ice, and cryogenic packs in reducing skin temperature. Phys Ther. 1987 Jul;67(7):1080-4. doi: 10.1093/ptj/67.7.1080.

    PMID: 3602101BACKGROUND

  • Chesterton LS, Foster NE, Ross L. Skin temperature response to cryotherapy. Arch Phys Med Rehabil. 2002 Apr;83(4):543-9. doi: 10.1053/apmr.2002.30926.

    PMID: 11932859BACKGROUND

Study Officials

  • Hernán Andrés de la Barra Ortiz, Mg

    Universidad Andrés Bello

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator and Clinical Professor

Study Record Dates

First Submitted

August 10, 2016

First Posted

August 30, 2016

Study Start

April 30, 2019

Primary Completion

November 12, 2019

Study Completion

March 20, 2020

Last Updated

April 3, 2020

Record last verified: 2020-02

Locations

CL(1)