The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

NCT01346995 | Completed

• 1 other identifier: 072.07
• Study Type: interventional
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Conditions

Muscle Strength

Outcome Measures

Primary Outcomes (1)

• Isokinetic knee muscle strength

  At baseline and after 8 weeks of exercise

Secondary Outcomes (1)

• One-leg chair rise

  At baseline and after 8 weeks of exercise

Study Arms (2)

Experimental Knee Pain

EXPERIMENTAL

Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad

Other: Experimental knee pain

Control

ACTIVE COMPARATOR

non-painful injections of isotonic saline into the infrapatellar fatpad.

Other: Non-painful control injections

Interventions

Experimental knee pain OTHER

Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad

Experimental Knee Pain

Non-painful control injections OTHER

Injection of isotonic saline into the infrapatellar fat pad

Control

Eligibility Criteria

• Age: 20 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• aged between 20 to 35 years
• healthy
• untrained (non-regular exercise participation \[i.e. \< 1 day/week\])

You may not qualify if:

• symptomatic musculoskeletal diseases
• history of traumatic injuries to muscles, tendons or joints of the lower extremity
• knee joint pain within a month prior to enrollment

Sponsors & Collaborators

• Frederiksberg University Hospital: lead

Related Publications (1)

• Sorensen TJ, Langberg H, Hodges PW, Bliddal H, Henriksen M. Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: a randomized controlled trial. Arthritis Care Res (Hoboken). 2012 Jan;64(1):108-16. doi: 10.1002/acr.20618.

  PMID: 21905254 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 2, 2011
• First Posted: May 4, 2011
• Study Start: February 1, 2010
• Primary Completion: August 1, 2010
• Study Completion: August 1, 2010
• Last Updated: May 4, 2011

Record last verified: 2010-02