Investigation of Fat Oxidation During Moderate Versus Vigorous Intensity Exercise

NCT03864679 | Completed

• 1 other identifier: Exercise 2018-1
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Exercise is widely suggested as an important lifestyle change for weight loss, however, the optimal level of intensity moderate versus vigorous remains unclear. It is known that in athletes, during very high-intensity exercise, fat oxidation is decreased and energy is gained mainly from carbohydrate utilization. The aim of this study is to find an optimal workload based on fat oxidation rate during exercise in volunteers with a sedentary lifestyle.

Conditions

Healthy; Sedentary Lifestyle

Keywords

exercise; fed; fasted; fat; carbohydrate

Outcome Measures

Primary Outcomes (2)

• Optimal workload

  The exercise workload (W) for optimal fat burning during exercise

  30 min accelerated load cycling exercise

• Heart rate change

  Change in heart rate (BPM) from rest to the optimal workload

  30 min accelerated load cycling exercise and 60 min optimal intensity cycling exercise

Secondary Outcomes (1)

• Influence of fed and fasted state

  30 min accelerated load cycling exercise

Study Arms (1)

Exercise

EXPERIMENTAL

Subjects will perform a cycling tests

Other: Exercise

Interventions

Exercise OTHER

Subjects will perform a cycling test with 5 min incremental intensity exercise and 1 h cycling test exercising at a moderate-intensity (load will be selected in incremental intensity exercise).

Exercise

Eligibility Criteria

• Age: 20 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Sedentary lifestyle
• BMI 20 - 30 kg/m2
• Be able to attend the laboratory and willing to participate in necessary protocols
• Be willing to undertake the duration of the exercise protocol (3 x 1 hour)
• Have the capacity and willingness to provide informed consent (oral and written)

You may not qualify if:

• athletes
• Individuals with chronic cardiovascular disease such as hypertension, valve disease, coronary artery disease, cardiac conduction abnormalities, etc.
• History of pneumothorax or chronic lung disease such as asthma, COPD, bronchiectasis
• Active Smokers
• Pregnant women

Sponsors & Collaborators

• Latvian Institute of Organic Synthesis: lead
• Riga East University Hospital: collaborator
• University of Latvia: collaborator
• Riga Stradins University: collaborator

Study Sites (1)

Latvian University

Riga, LV-1004, Latvia

Location

MeSH Terms

Conditions

Sedentary Behavior; Motor Activity; Lecithin Cholesterol Acyltransferase Deficiency; Platelet Glycoprotein IV Deficiency

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior; Hypoalphalipoproteinemias; Hypolipoproteinemias; Lipid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ilze Konrade

  Riga East University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 22, 2018
• First Posted: March 6, 2019
• Study Start: June 18, 2018
• Primary Completion: August 15, 2018
• Study Completion: August 30, 2018
• Last Updated: March 6, 2019

Record last verified: 2019-03

Data Sharing

• IPD Sharing: Will not share

Locations

LA (1)