NCT00647452

Brief Summary

Purpose: To investigate VLDL-TG metabolism in exercise in healthy volunteers to determine the contribution of VLDL-TG in exercise and eventual gender differences

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
16

participants targeted

Target at below P25 for not_applicable healthy

Timeline
Completed

Started Apr 2008

Typical duration for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 26, 2008

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 31, 2008

Completed
1 day until next milestone

Study Start

First participant enrolled

April 1, 2008

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2009

Completed
Last Updated

November 8, 2011

Status Verified

November 1, 2011

Enrollment Period

1 year

First QC Date

March 26, 2008

Last Update Submit

November 7, 2011

Conditions

Healthy

Keywords

Lipid metabolismVLDLExerciseLipid metabolism in exercise

Outcome Measures

Primary Outcomes (1)

  • VLDL-TG turnover

    Hours

Study Arms (2)

1

EXPERIMENTAL

Healthy male volunteers

Behavioral: Exercise

2

EXPERIMENTAL

Healthy female volunteers

Behavioral: Exercise

Interventions

ExerciseBEHAVIORAL

Moderate Intensity Exercise (50 % af VO2max) for 90 minutes

12

Eligibility Criteria

Age20 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy
  • Age: 20-50 years
  • Premenopausal

You may not qualify if:

  • Smoking
  • Alcohol abuse
  • Use of medications

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Endocrinology M, Aarhus Hospital

Aarhus C, 8000, Denmark

Location

Related Publications (2)

  • Mittendorfer B, Horowitz JF, Klein S. Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E58-65. doi: 10.1152/ajpendo.00504.2001.

    PMID: 12067843BACKGROUND

  • Gormsen LC, Jensen MD, Nielsen S. Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer. J Lipid Res. 2006 Jan;47(1):99-106. doi: 10.1194/jlr.M500205-JLR200. Epub 2005 Oct 18.

    PMID: 16234572BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Esben Søndergaard, M.D.

    Medical Department M

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 26, 2008

First Posted

March 31, 2008

Study Start

April 1, 2008

Primary Completion

April 1, 2009

Study Completion

April 1, 2009

Last Updated

November 8, 2011

Record last verified: 2011-11

Locations

DK(1)