Effect of Exercise on Genes That Control Muscle Function

NCT03414385 | Completed DMC

• 2 other identifiers: H-403661R01DK111436-01A1
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed project will examine how exercise counteracts metabolic disorders and type 2 diabetes through regulating gene expression. The project is highly relevant to public health because of the global pandemic of diabetes, obesity, and associated metabolic syndromes as well as the well-known metabolic benefit of physical exercise in correcting these disorders.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Change in JunD/AP-1 signaling in human skeletal muscle

  JunD/AP-target genes

  Immediately after about 2 hours exercise

Study Arms (1)

Exercise group

EXPERIMENTAL

Research volunteers will be asked to undergo an acute bout of aerobic exercise at moderate intensity for \~120 minutes. Before and after the exercise the volunteer will undergo leg biopsy.

Other: Exercise

Interventions

Exercise OTHER

Acute bout of aerobic exercise at moderate intensity for 2 hours

Exercise group

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 20 - 40 years
• BMI 18.5 - 29.9
• Stable body weight (not more than 2 kg change) during the past 6 months
• Moderate sedentary (regular exercise less than 1 hour per week for the last 6 months)
• Willing to provide informed consent

You may not qualify if:

• Failure to provide informed consent
• Any major chronic disease or any condition that would interfere with exercise, in which exercise is contraindicated, or that would interfere with interpretation of results
• Severe orthopedic and or neuromuscular disease that would contraindicate participation in exercise
• Other significant co-morbid disease that would impair ability to exercise
• Uncontrolled hypertension (BP greater than 160/90)
• History of malignancy during the past 5 years
• Diabetes mellitus as determined by self-report with verification (medical records, current treatment, confirmation from health care provider), or HbA1c of exceeding 6.5%

Sponsors & Collaborators

• Baylor College of Medicine: lead
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): collaborator
• US Department of Veterans Affairs: collaborator

Study Sites (1)

Baylor College of Medicine/Michael E DeBakey VA Medical Center

Houston, Texas, 77030, United States

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Dennis T Villareal, MD

  Baylor College of Medicine

  PRINCIPAL INVESTIGATOR

• Zheng Sun, PhD

  Baylor College of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 17, 2018
• First Posted: January 29, 2018
• Study Start: February 1, 2018
• Primary Completion: December 31, 2019
• Study Completion: May 31, 2022
• Last Updated: March 23, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)