Metabolic Thresholds and Fat Utilization Points Correlation

NCT03789045 | Completed

• 1 other identifier: 12345
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

To examine existence of connection between fat utilization points, both maximal and minimal with individual metabolic thresholds in different subjects. As a consequence, this innovative approach could offer a supplementary method for both aerobic and anaerobic thresholds detection as well as useful and practical exercise intensity selection marker.

Conditions

Exercise Physiology

Keywords

Exercise; Metabolic thresholds; Fat oxidation

Outcome Measures

Primary Outcomes (1)

• Relationship between metabolic threshold and fat oxidation points (FATmax) matching %HRmax

  Regular exercise at FATmax intensity has been proposed as a key factor to optimize the body's ability to oxidize lipids.Exercise intensity matching FATmax will be determined via indirect calorimetry and expressed by using %HRmax.In contrast to the %HRmax method, an individualized approach to exercise intensity prescription based on metabolic thresholds describes specific metabolic phases during exercise and intends to account for differences in the body's physiological and functional capacity.Metabolic thresholds will be determined via either gas analysis or/and lactate analysis and expressed in %HRmax.If connection between these two %HRmax exists,it would integrate the most relevant indices for planning and assessing an effective exercise program.Existence of connection between %HRmax matching both parameters will be evaluated by using correlation and levels of agreement by using MedCalc statistical software.

  Each primary outcome measure (metabolic thresholds and fat oxidation points, is sampled continuously through the test. Test duration is 12-16 minutes.Existence of correlation will be evaluated immediately after test

Secondary Outcomes (1)

• Relationship between metabolic threshold and fat oxidation points (FATmax) matching %VO2max

  Each primary outcome measure (metabolic thresholds and fat oxidation points, is sampled continuously through the test. Test duration is 12-16 minutes. Existence of correlation will be evaluated immediately after test

Study Arms (3)

Obese men and women

Metabolic thresholds and fat oxidation points relationship in Obese males and females, age 18-60y, body fat \> 30%

Diagnostic Test: Metabolic thresholds and fat oxidation points relationship

Male and female athletes

Metabolic thresholds and fat oxidation points relationship in Athletic males and females, age 18-60y.

Diagnostic Test: Metabolic thresholds and fat oxidation points relationship

Sedentary females and males

Metabolic thresholds and fat oxidation points relationship in Sedentary females and males, age 18-60y,

Diagnostic Test: Metabolic thresholds and fat oxidation points relationship

Interventions

Metabolic thresholds and fat oxidation points relationship DIAGNOSTIC_TEST

Investigators aim to determine exercise intensity at which metabolic thresholds and fat oxidation points occur by using non-invasive breath-by-breath gas analysis during either graded treadmill or cycle ergometry test (2min stages and 1km/h or 50 W load increase) till exhaustion to determine maximal oxygen uptake (VO2max), with gases being collected at the mouth level. The strength of the relationship between AeT and at FATmax will be assessed using the Pearson product moment (r) correlation coefficient with same being done for AnT and FATmin correlation. A coefficient of determination (R2) will be used to detect the proportion of existing variance. A paired t-test will be used to asses' differences between measured variables. Bland-altman will be used to determine levels of agreement.

Male and female athletes; Obese men and women; Sedentary females and males

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Athletic, moderately trained, sedentary and obese males and females

You may qualify if:

• Healthy
• Non smokers
• No evidence of any metabolic, pulmonary or cardiovascular diseases possibly affecting substrates utilization.
• No presence of musculoskeletal injuries (Must be able to perform graded exercise test on a treadmill or a cycle ergometer).
• Males and females, age 18-60, divided in following 4 groups: obese, sedentary, moderately trained, athletes.
• For obese group of individuals, body fat \> 30%
• For sedentary group of individuals, no physical activity in last 3 years
• For athletic group of individuals, \> 12 h training per week
• For moderately trained individuals. \< 3 h per week of physical activity
• Willing to allow data publication.

You may not qualify if:

• Evidence of any metabolic, pulmonary or cardiovascular diseases possibly affecting substrates utilization.
• Smokers.
• High blood pressure.
• Using supplements possibly affecting substrates utilization.
• Non willing to allow data publication.
• Not finishing grade exercise test protocol till exhaustion to determine VO2max.

Sponsors & Collaborators

• Sport Studio Banja Luka: lead
• Aspire Medical: collaborator
• Appalachian State University: collaborator
• University of South Australia: collaborator
• University Ghent: collaborator
• University of Birmingham: collaborator
• Stanford University: collaborator
• Cosmed USA, Inc.: collaborator
• University Hospital of Split: collaborator
• University of Urbino "Carlo Bo": collaborator
• Universidad de Granada: collaborator
• Autonomous University of Ciudad Juarez: collaborator

Study Sites (1)

Sport Studio Banja Luka

Banja Luka, 78000, Bosnia and Herzegovina

Location

Related Publications (9)

• Peric R, DI Pietro A, Myers J, Nikolovski Z. A systematic comparison of commonly used stoichiometric equations to estimate fat oxidation during exercise in athletes. J Sports Med Phys Fitness. 2021 Oct;61(10):1354-1361. doi: 10.23736/S0022-4707.20.11747-X. Epub 2020 Dec 14.

  PMID: 33314884 BACKGROUND

• Peric R, Meucci M, Nikolovski Z. Fat Utilization During High-Intensity Exercise: When Does It End? Sports Med Open. 2016 Dec;2(1):35. doi: 10.1186/s40798-016-0060-1. Epub 2016 Aug 31.

  PMID: 27747790 RESULT

• Peric R, Meucci M, Bourdon PC, Nikolovski Z. Does the aerobic threshold correlate with the maximal fat oxidation rate in short stage treadmill tests? J Sports Med Phys Fitness. 2018 Oct;58(10):1412-1417. doi: 10.23736/S0022-4707.17.07555-7. Epub 2017 Jul 25.

  PMID: 28745473 RESULT

• Meucci M, Peric R. Correlation Between Aerobic Threshold And Point Of Maximal Fat Utilization In Male Runners: 1678 Board #331 June 2, 8: 00 AM - 9: 30 AM. Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):466-7. doi: 10.1249/01.mss.0000486403.83644.7e.

  RESULT

• Peric R, Nikolovski Z. Can metabolic thresholds be used as exercise intensity markers in adult men with obesity - fat burn points used as an exercise marker. Comparative Exercise Physiology: 16 (2)- Pages: 113 - 119. https://doi.org/10.3920/CEP190035

  RESULT

• Nikolovski Z, Barbaresi S, Cable T, Peric R. Evaluating the influence of differences in methodological approach on metabolic thresholds and fat oxidation points relationship. Eur J Sport Sci. 2021 Jan;21(1):61-68. doi: 10.1080/17461391.2020.1717640. Epub 2020 Jan 31.

  PMID: 31944160 RESULT

• Meucci M, Nandagiri V, Kavirayuni VS, Whang A, Collier SR. Correlation Between Heart Rate at Maximal Fat Oxidation and Aerobic Threshold in Healthy Adolescent Boys and Girls. Pediatr Exerc Sci. 2021 May 6;33(3):139-143. doi: 10.1123/pes.2020-0210.

  PMID: 33958504 RESULT

• Peric R, Nikolovski Z, Meucci M, Tadger P, Ferri Marini C, Amaro-Gahete FJ. A Systematic Review and Meta-Analysis on the Association and Differences between Aerobic Threshold and Point of Optimal Fat Oxidation. Int J Environ Res Public Health. 2022 May 26;19(11):6479. doi: 10.3390/ijerph19116479.

  PMID: 35682065 RESULT

• Ferri Marini C, Tadger P, Chavez-Guevara IA, Tipton E, Meucci M, Nikolovski Z, Amaro-Gahete FJ, Peric R. Factors Determining the Agreement between Aerobic Threshold and Point of Maximal Fat Oxidation: Follow-Up on a Systematic Review and Meta-Analysis on Association. Int J Environ Res Public Health. 2022 Dec 27;20(1):453. doi: 10.3390/ijerph20010453.

  PMID: 36612784 RESULT

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Ratko Peric, Doctorate

  Sport Studio Banja Luka

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Exercise Physiologist PhD

Study Record Dates

• First Submitted: December 21, 2018
• First Posted: December 28, 2018
• Study Start: May 1, 2016
• Primary Completion: December 30, 2022
• Study Completion: December 30, 2022
• Last Updated: January 20, 2023

Record last verified: 2023-01

Locations

BO (1)