Olfactory Decision-making and Deprived Sleep

NCT05093413 | Completed

• 1 other identifier: STU00215342
• Study Type: interventional
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.

Conditions

Sleep Deprivation

Outcome Measures

Primary Outcomes (1)

• Behavior an olfactory perceptual decision-making task

  Food-like perceptual responses to binary food-nonfood odor mixtures

  Up to 24 hours after the intervention

Secondary Outcomes (1)

• Resting-state functional magnetic resonance imaging

  Up to 24 hours after the intervention

Study Arms (2)

Fully slept first; Sleep deprived second

EXPERIMENTAL

Participants will be fully slept during the first experimental visit and sleep deprived during the second experimental visit

Behavioral: Sleep deprivation

Sleep deprived first; Fully slept second

EXPERIMENTAL

Participants will be sleep deprived during the first experimental visit and fully slept during the second experimental visit

Behavioral: Sleep deprivation

Interventions

Sleep deprivation BEHAVIORAL

Fully slept: Sleep habitual amount (i.e., go to sleep at habitual bedtime and wake up at habitual wake time) Sleep deprived: Reduce sleep by 50% (i.e., go to sleep at habitual bedtime and wake up early)

Fully slept first; Sleep deprived second; Sleep deprived first; Fully slept second

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 18 years old
• Fluent English speakers

You may not qualify if:

• History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
• History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)
• Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
• Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
• Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
• Smell or taste dysfunction
• History of severe allergies requiring hospitalization for treatment
• History of severe asthma requiring hospitalization for treatment
• Habitual smoking
• History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
• Dieting or fasting
• History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
• Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
• History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
• Left-handedness

Sponsors & Collaborators

• Northwestern University: lead

Study Sites (1)

Northwestern University

Chicago, Illinois, 60611, United States

Location

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Thorsten Kahnt, PhD

  Associate Professor

  PRINCIPAL INVESTIGATOR

• Christina Zelano, PhD

  Assistant Professor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 29, 2021
• First Posted: October 26, 2021
• Study Start: January 14, 2021
• Primary Completion: May 19, 2022
• Study Completion: May 19, 2022
• Last Updated: July 13, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will share
• Time Frame: Data may be shared upon publication
• Access Criteria: Data can be obtained from the PI for non-profit purposes upon reasonable request

Locations

US (1)