Extinction Learning in Youth With Tourette Syndrome

NCT03765463 | Completed

• 1 other identifier: IRB00195059
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but have not been directly evaluated in youth with Tourette syndrome (TS). This study examines extinction learning and extinction recall in youth with TS using an experimental task. This study will also explore the relationship between extinction processes (i.e., extinction learning and extinction recall) and treatment outcomes with behavior therapy. Findings from this investigation will be used to update the behavioral treatment model, which serves as the basis for evidence-based behavioral interventions.

Conditions

Tourette Syndrome in Children; Tourette Syndrome in Adolescence; Habit Reversal Training; Tic

Keywords

Extinction learning; Behavior Therapy; Tourette's Disorder; Habit Reversal Training; Comprehensive Behavioral Intervention for Tics

Outcome Measures

Primary Outcomes (1)

• Tic severity as assessed by the Hopkins Motor and Vocal Tic Scale (HM/VTS)

  Patient will nominate up to five motor and five vocal tics they deem bothersome on the HM/VTS. Each bothersome tic is then rated by a clinician on the composite two (vocal and motor) 5-point HM/VTS scale ranging from none (0) to severe (4) for the motor as well as vocal tics. The individual tic scores are summed (minimum of 0 and maximum of 40) and averaged together to create an average tic severity score.

  Within 1 week after completion of HRT

Secondary Outcomes (1)

• Tic severity as assessed by the Yale Global Tic Severity Scale-Revised (YGTSS)

  Within 1 week after completion of HRT

Study Arms (1)

Habit Reversal Training

EXPERIMENTAL

Habit Reversal Training (HRT) is a multi-component evidence-based treatment for tics. It will be delivered over 4 two-hour sessions in an intensive format.

Behavioral: Habit Reversal Training

Interventions

Habit Reversal Training BEHAVIORAL

4 sessions of habit reversal training

Habit Reversal Training

Eligibility Criteria

• Age: 8 Years - 17 Years
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• age 8-17 years (inclusive)
• have moderate tic severity or greater as evidenced by a YGTSS Total Tic Score greater than 13 (\>9 for youth with motor or vocal tics only)
• have not received more than 4 previous sessions of HRT
• be fluent in English.
• Medication free or on a stable dose of psychiatric medication for 8 weeks prior to enrollment.

You may not qualify if:

• An inability to complete rating scales
• Attend study visits.

Sponsors & Collaborators

• Johns Hopkins University: lead

Study Sites (1)

Johns Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States

Location

MeSH Terms

Conditions

Tics; Tourette Syndrome

Condition Hierarchy (Ancestors)

Dyskinesias; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Tic Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Joseph F McGuire, PhD

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2018
• First Posted: December 5, 2018
• Study Start: February 28, 2019
• Primary Completion: February 1, 2023
• Study Completion: August 2, 2023
• Last Updated: August 8, 2023

Record last verified: 2023-08

Locations

US (1)