Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome

NCT04179435 | Unknown

• 2 other identifiers: C19-112019-A00992-55
• Study Type: interventional
• Target: 132
• Locations: 0 countries
• Sites: N/A

Brief Summary

In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.

Conditions

Tourette Syndrome in Adolescence

Outcome Measures

Primary Outcomes (6)

• Behavioral test main outcome measures [1]

  reaction times

  from 16 to 20 months

• Behavioral test main outcome measures [2]

  discounting factor

  from 16 to 20 months

• Behavioral test main outcome measures [3]

  number of premature responses

  from 16 to 20 months

• Behavioral test main outcome measures [4]

  agency composite scores

  from 16 to 20 months

• Brain MRI scan measures

  whole brain structural connectivity, whole brain functional connectivity, brain cortical and subcortical structures volumes and morphology

  from 16 to 20 months

• Transcranial magnetic stimulation

  intracortical inhibition (SICI) scores

  from 16 to 20 months

Study Arms (2)

Tourette syndrome

OTHER

Patients with Tourette syndrome aged 13 - 18 y.o. Interventions : Brain scans, cognitive testing, TMS measures

Behavioral: Behavioral testing on cognitive computerized tasks; Other: brain MRI; Other: TMS

Controls

OTHER

Controls matched to Tourette syndrome group nterventions : Brain scans, cognitive testing, TMS measures

Behavioral: Behavioral testing on cognitive computerized tasks; Other: brain MRI; Other: TMS

Interventions

Behavioral testing on cognitive computerized tasks BEHAVIORAL

Testing on cognitive computerized tasks

Controls; Tourette syndrome

brain MRI OTHER

Brain MRI scans

Controls; Tourette syndrome

TMS OTHER

Measure of the cortical inhibitory capacity using TMS measures

Controls; Tourette syndrome

Eligibility Criteria

• Age: 13 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Tourette syndrome
• Ages 13 - 18
• Acceptance to perform the Brain MRI
• Acceptance to perform the cognitive testing
• Acceptance to perform the TMS measures

You may not qualify if:

• Learning disability
• Incompatibility with MRI procedure (metal body implants, pregnancy)

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Related Publications (1)

• Atkinson-Clement C, Duflot M, Lastennet E, Patsalides L, Wasserman E, Sartoris TM, Tarrano C, Rosso C, Burbaud P, Deniau E, Czernecki V, Roze E, Hartmann A, Worbe Y. How does Tourette syndrome impact adolescents' daily living? A text mining study. Eur Child Adolesc Psychiatry. 2023 Dec;32(12):2623-2635. doi: 10.1007/s00787-022-02116-1. Epub 2022 Dec 2.

  PMID: 36460852 DERIVED

Study Officials

• Worbe Yulia, MD, PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Worbe Yulia, MD, PhD

CONTACT

+ 33 1 57 43 55; Yulia.worbe@aphp.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Model Details: Between group comparison

Study Record Dates

• First Submitted: November 20, 2019
• First Posted: November 27, 2019
• Study Start: December 1, 2019
• Primary Completion: December 1, 2021
• Study Completion: December 1, 2023
• Last Updated: November 27, 2019

Record last verified: 2019-11

Data Sharing

• IPD Sharing: Will not share