Extinction Learning in Adults With Tourette Syndrome

NCT04498364 | Completed

• 1 other identifier: IRB00256962
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but are still understudied for individuals with Tourette syndrome (TS). This study examines extinction learning and extinction recall in adults with TS using an experimental task. This study will also explore the relationship between extinction processes (i.e., extinction learning and extinction recall) and treatment outcomes with behavior therapy. Findings from this investigation will be used to update the behavioral treatment model, which serves as the basis for evidence-based behavioral interventions.

Conditions

Tourette Syndrome; Habit Reversal Training; Tic Disorders; Tics; Comprehensive Behavioral Intervention for Tics

Keywords

Extinction Learning; Comprehensive Behavioral Intervention for Tics; Behavior Therapy; Habit Reversal Training; Tourette's Disorder

Outcome Measures

Primary Outcomes (1)

• Tic severity as assessed by the Hopkins Motor and Vocal Tic Scale (HM/VTS)

  Patient will nominate up to five motor and five vocal tics they deem bothersome on the HM/VTS. Each bothersome tic is then rated by a clinician on the composite two (vocal and motor) 5-point HM/VTS scale ranging from none (0) to severe (4) for the motor as well as vocal tics. The individual tic scores are summed (minimum of 0 and maximum of 40) and averaged together to create an average tic severity score.

  Within 1 week after completion of HRT

Secondary Outcomes (1)

• Tic severity as assessed by the Yale Global Tic Severity Scale-Revised (YGTSS)

  Within 1 week after completion of HRT

Study Arms (1)

Habit Reversal Training

EXPERIMENTAL

Habit Reversal Training (HRT) is a multi-component evidence-based treatment for tics. It will be delivered over 8 hours of treatment.

Behavioral: Habit Reversal Training

Interventions

Habit Reversal Training BEHAVIORAL

Habit Reversal Training (HRT) is a multi-component evidence-based treatment for tics.

Habit Reversal Training

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 18 years old,
• Have moderate tic severity or greater as evidenced by a YGTSS Total Tic Score greater than 13 (\>9 for youth with motor or vocal tics only)
• Have not received more than 4 previous sessions of HRT
• Be fluent in English
• Medication free or on a stable dose of psychiatric medication for 8 weeks prior to enrollment.

You may not qualify if:

• An inability to complete rating scales
• An inability to attend study visits

Sponsors & Collaborators

• Johns Hopkins University: lead

Study Sites (1)

Johns Hopkins University School of Medicine

Baltimore, Maryland, 21205, United States

Location

MeSH Terms

Conditions

Tourette Syndrome; Tic Disorders; Tics

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders; Mental Disorders; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Joseph F McGuire, PhD

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 31, 2020
• First Posted: August 4, 2020
• Study Start: September 18, 2020
• Primary Completion: September 22, 2023
• Study Completion: October 17, 2023
• Last Updated: October 23, 2023

Record last verified: 2023-10

Locations

US (1)