Taurine Supplementation and Exercise on Irisin Levels in Obesity

NCT04646512 | Completed DMC

• 1 other identifier: 51921115500005426
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Irisin is a myocin secreted by skeletal muscle in stimulus to physical exercise and has been described as a possible therapeutic tool in the fight against obesity by triggering a cascade of signaling that triggers the expression of genes responsible for the increase in energy expenditure and browning of adipose tissue white cells by activating thermogenesis promoter mitochondrial proteins. Although the science is engaged in the search for evidences about the actions of the irisin, the physical exercise involved and the improvement in the levels of obesity, many mechanisms are still unknown. Since taurine by means of irisin-like pathways also increases energy expenditure, it is believed that taurine supplementation associated with high intensity aerobic physical exercise can optimize the effects of irisin, increasing energy expenditure and improving body composition in obesity.

Conditions

Obesity

Keywords

Obesity; Exercise; Irisin; Taurine; Energy Expenditure

Outcome Measures

Primary Outcomes (9)

• Changes body weight

  The body weight was measured by digital balance before and after the intervention

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes body composition

  The body composition was evaluated through deuterium oxide

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes indirect calorimetry

  With a gas analyzer (indirect calorimeter), we evaluated the metabolic rate and rest (REE) and oxidation of substrates (lipids and carbohydrates)

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes in total cholesterol and lipid fractions

  Collected in EDTA tubes, were centrifuged.

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes in plasma taurine concentration

  Collected in EDTA tubes, were centrifuged and the plasma taurine concentration was evaluated using HPLC (high performance liquid chromatography).

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes in plasma irisin concentration

  Collected in EDTA tubes, were centrifuged and the plasma irisin concentration was evaluated using Multiplex - Kit Human Myokine Magnetic Bead Panel.

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes Food intake

  Food registry of 3 days. The quantification of the daily intake of nutrients will still be made using sofware.

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes in determination of lactate

  Blood samples were collected by manual puncture of the earlobe in previously calibrated and heparinized capillary tubes, stored in eppendorf with sodium fluoride. Analyzed by electrochemical lactate analyser.

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

• Changes Physical Performance

  Maximum effort test, according to Wilder, Brennan e Schotte (1993).

  Two times: (1) First day and (2) 10 weeks after assessments, adaptation and intervention

Study Arms (2)

Taurine group and exercise

ACTIVE COMPARATOR

Intervention with taurine supplementation and physical training.

Dietary Supplement: Taurine group and exercise and placebo group and exercise; Other: Physical training with Deep Water Running

Placebo group and exercise

PLACEBO COMPARATOR

Intervention with placebo supplementation and physical training.

Dietary Supplement: Taurine group and exercise and placebo group and exercise; Other: Physical training with Deep Water Running

Interventions

Taurine group and exercise and placebo group and exercise DIETARY_SUPPLEMENT

Both groups supplemented with taurine and / or placebo will perform physical training.

Placebo group and exercise; Taurine group and exercise

Physical training with Deep Water Running OTHER

There will be a physical training for eight weeks.

Placebo group and exercise; Taurine group and exercise

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• This study included women with obesity grade I (BMI ≥30 - ≤35Kg/m²), sedentary, with no associated comorbidity, convenience sample.

You may not qualify if:

• Women classified as overweight, obesity grade II and grade III (morbid), who present comorbidities associated with obesity (pre-diabetes, diabetes, hypertension, dyslipidemia, cardiovascular diseases and diseases of bone metabolism); smokers; who use hormones, sports supplements and / or weight loss medications. Perform some type of nutritional monitoring followed by diet or weight loss guidelines and that have medical impediment to the practice of physical exercise.

Sponsors & Collaborators

• University of Sao Paulo: lead

Study Sites (1)

Gabriela Batitucci

Ribeirão Preto, São Paulo, Brazil

Location

MeSH Terms

Conditions

Obesity; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Intervention with taurine and / or placebo supplementation and physical training
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: double blind trial

Study Record Dates

• First Submitted: November 20, 2020
• First Posted: November 30, 2020
• Study Start: February 1, 2016
• Primary Completion: May 1, 2016
• Study Completion: August 1, 2016
• Last Updated: November 30, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)