The Glycaemic Response of Local Foods Using the Continuous Glucose Monitoring System

NCT03703544 | Completed

• 1 other identifier: 2017/00994
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

This study is carried out to determine the effect of high and low GI of local foods using Continuous Glucose Monitoring System (CGMS™) on 24 hour blood glucose profiles.

Conditions

Diabetes

Outcome Measures

Primary Outcomes (1)

• Daily blood glucose profile

  The daily total blood glucose response is measured for each low and high GI treatment as the area under the curve over 24 hours using CGMS for breakfast, lunch, snack and dinner.

  24 hours

Study Arms (2)

High glycemic index

EXPERIMENTAL

Subjects will consume locally consumed meals which are high glycemic index for breakfast, lunch snack and dinner will be provided.Participants' blood glucose will be monitored using the Continuous Glucose Monitor.

Other: High glycemic index

Low glycemic index

EXPERIMENTAL

Subjects will consume locally consumed meals which are low glycemic index for breakfast, lunch snack and dinner will be provided. Participants' blood glucose will be monitored using the Continuous Glucose Monitor.

Other: Low glycemic index

Interventions

High glycemic index OTHER

Wheat yellow noodle, glutinous rice, tea with sucrose, biscuits, jelly made with sucrose and teriyaki chicken rice.The foods provided have been tested as high glycemic index. Participants' blood glucose will be monitored using the Continuous Glucose Monitor.

High glycemic index

Low glycemic index OTHER

Beta-glucan yellow noodle, basmati rice, tea with isomaltulose, biscuits, jelly made with isomaltulose and mung bean noodles.The foods provided have been tested as low glycemic index.Participants' blood glucose will be monitored using the Continuous Glucose Monitor.

Low glycemic index

Eligibility Criteria

• Age: 21 Years - 50 Years
• Gender Eligibility Details: Healthy male participants
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Chinese, male
• Age between 21-50 years
• Body mass index between 18 to 25 kg/m2
• Normal blood pressure (\<140/90 Hgmm)
• Fasting blood glucose \< 6 mmol/L

You may not qualify if:

• Current Smoker
• Have any metabolic diseases (such as diabetes, hypertension etc)
• Have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• Have an ongoing infection or currently undergoing treatment at the time of screening
• Known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)• Have active Tuberculosis (TB) or currently receiving treatment for TB
• Have intolerances or allergies to any foods
• Partake in sports at the competitive and/or endurance levels

Sponsors & Collaborators

• Singapore Institute of Food and Biotechnology Innovation: lead
• Health Promotion Board, Singapore: collaborator

Study Sites (1)

Clinical Nutrition Research Centre

Singapore, 117599, Singapore

Location

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 9, 2018
• First Posted: October 12, 2018
• Study Start: December 15, 2017
• Primary Completion: May 22, 2020
• Study Completion: May 22, 2020
• Last Updated: July 17, 2020

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)