NCT03656536

Brief Summary

The purpose of this study is to evaluate the efficacy and safety of pemigatinib versus gemcitabine plus cisplatin chemotherapy in first-line treatment of participants with unresectable or metastatic cholangiocarcinoma with FGFR2 rearrangement.

Trial Health

68
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
167

participants targeted

Target at P25-P50 for phase_3

Timeline
Completed

Started Jun 2019

Longer than P75 for phase_3

Geographic Reach
19 countries

215 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 29, 2018

Completed
6 days until next milestone

First Posted

Study publicly available on registry

September 4, 2018

Completed
9 months until next milestone

Study Start

First participant enrolled

June 3, 2019

Completed
6.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 7, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 7, 2025

Completed
Last Updated

August 24, 2025

Status Verified

August 1, 2025

Enrollment Period

6.1 years

First QC Date

August 29, 2018

Last Update Submit

August 19, 2025

Conditions

Keywords

Cholangiocarcinomafibroblast growth factor receptor inhibitorFGFRFGFR rearrangement

Outcome Measures

Primary Outcomes (1)

  • Progression-free survival

    Defined as the time from date of randomization until date of disease progression (according to Response Evaluation Criteria in Solid Tumors \[RECIST\] v1.1 and assessed by an independent central reviewer (ICR)) or death, whichever occurs first.

    Up to approximately 12 months

Secondary Outcomes (8)

  • Overall response rate

    Up to approximately 12 months

  • Overall survival

    Up to approximately 12 months

  • Duration of response

    Up to approximately 12 months

  • Disease control rate

    Up to approximately 12 months

  • Number of treatment-emergent adverse events

    Up to approximately 12 months

  • +3 more secondary outcomes

Study Arms (2)

Pemigatinib

EXPERIMENTAL
Drug: Pemigatinib

Gemcitabine + Cisplatin

ACTIVE COMPARATOR

Participants who experience disease progression while receiving gemcitabine + cisplatin or during the follow-up period and before starting a new anticancer therapy will be eligible to cross over and receive pemigatinib.

Drug: GemcitabineDrug: Cisplatin

Interventions

Pemigatinib at the protocol-defined dose administered orally once daily as continuous therapy schedule (a cycle is 3 weeks).

Also known as: INCB054828
Pemigatinib

Gemcitabine 1000 mg/m\^2 administered as an intravenous infusion on Days 1 and 8 of every 3-week cycle for up to 8 cycles.

Gemcitabine + Cisplatin

Cisplatin 25 mg/m\^2 administered as an intravenous infusion on Days 1 and 8 of every 3-week cycle for up to 8 cycles.

Gemcitabine + Cisplatin

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male and female participants at least 18 years of age at the time of signing the informed consent form (ICF).
  • Histologically or cytologically confirmed cholangiocarcinoma that is previously untreated and considered unresectable and/or metastatic (Stage IV per the American Joint Committee on Cancer (AJCC) Cancer Staging Manual).
  • Radiographically measurable or evaluable disease by CT or MRI per RECIST v1.1 criteria.
  • Eastern Cooperative Oncology Group performance status 0 to 1.
  • Documented FGFR2 rearrangement.
  • Willingness to avoid pregnancy or fathering children.

You may not qualify if:

  • Received prior anticancer systemic therapy for unresectable and/or metastatic disease (not including adjuvant/neo-adjuvant treatment completed at least 6 months prior to enrollment, and participants that have received treatment for locally advanced disease with trans-arterial chemoembolization or selective internal radiation therapy, if clear evidence of radiological progression is observed before enrollment, or enrolled as of Amendment 6 (or Amendment 5-JP2) and the participant received 1 cycle of gemcitabine plus cisplatin \[the start of study drug {Cycle 1 Day 1} must be at least 14 days and ≤ 4 weeks {28 days} from the last dose of gemcitabine plus cisplatin\]).
  • Child-Pugh B and C.
  • Toxicities related to prior therapy(ies) must be Common Terminology Criteria for Adverse Events (CTCAE) v5.0 ≤ Grade 1 at the time of screening.
  • Concurrent anticancer therapy, other than the therapies being tested in this study.
  • Participant is a candidate for potentially curative surgery.
  • Current evidence of clinically significant corneal (including but not limited to bullous/band keratopathy, corneal abrasion, inflammation/ulceration, and keratoconjunctivitis) or retinal disorder (including but not limited to central serous retinopathy, macular/retinal degeneration, diabetic retinopathy, retinal detachment) as confirmed by ophthalmologic examination.
  • Radiation therapy administered within 4 weeks of enrollment/randomization/first dose of study treatment.
  • Known central nervous system (CNS) metastases or history of uncontrolled seizures.
  • Known additional malignancy that is progressing or requires active treatment (exceptions: basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or in situ cervical cancer that has undergone potentially curative therapy).
  • Laboratory values at screening outside the protocol-defined range.
  • History of calcium and phosphate hemostasis disorder or systemic mineral imbalance with ectopic calcification of soft tissues (exception: commonly observed calcifications in soft tissues, such as the skin, kidney, tendons or vessels due to injury, disease, and aging, in the absence of systemic mineral imbalance).
  • Significant gastrointestinal disorders that could interfere with absorption, metabolism, or excretion of pemigatinib.
  • Clinically significant or uncontrolled cardiac disease.
  • History or presence of an abnormal ECG, which, in the investigator's opinion, is clinically meaningful.
  • Chronic or current active infectious disease requiring systemic antibiotics or antifungal or antiviral treatment within 2 weeks prior to enrollment (participants with asymptomatic chronic infections on prophylactic treatment are allowed). Note: HIV-positive participants are allowed if all of the following criteria are met: CD4+ count ≥ 300/µL, undetectable viral load, receiving antiretroviral therapy that does not interact with study drug, and no HIV/AIDS-associated opportunistic infection in the last 12 months.
  • +3 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (215)

Mayo Clinic Arizona

Phoenix, Arizona, 85054, United States

Location

Marin Cancer Care

Greenbrae, California, 94904, United States

Location

UC Irvine Medical Center

Orange, California, 92868-3201, United States

Location

Georgetown University-Lombardi Comprehensive Cancer Center

Washington D.C., District of Columbia, 20007, United States

Location

Mayo Clinic-Florida

Jacksonville, Florida, 32224, United States

Location

Mount Sinai Medical Center Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States

Location

Winship Cancer Institute of Emory University

Atlanta, Georgia, 30322, United States

Location

University of Chicago Medical Center

Chicago, Illinois, 60637-1447, United States

Location

Parkview Research Center

Fort Wayne, Indiana, 46845, United States

Location

University of Iowa Hospital and Clinics

Iowa City, Iowa, 52242, United States

Location

The University of Kansas Cancer Center

Westwood, Kansas, 66205, United States

Location

Ochsner Clinic Foundation Ocf Ochsner Cancer Institute Oci

New Orleans, Louisiana, 70121, United States

Location

Johns Hopkins Oncology Center

Baltimore, Maryland, 21287, United States

Location

Boston Medical Center

Boston, Massachusetts, 02118, United States

Location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

Barbara Ann Karmanos Cancer Hospital

Detroit, Michigan, 48201, United States

Location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

Karmanos Cancer Institute

Farmington Hills, Michigan, 48334, United States

Location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

Comprehensive Cancer Centers of Nevada-Twain

Las Vegas, Nevada, 89169, United States

Location

Summit Medical Group

Florham Park, New Jersey, 07932, United States

Location

Icahn School of Medicine At Mount Sinai

New York, New York, 10029, United States

Location

White Plains Hospital

White Plains, New York, 10601, United States

Location

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States

Location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

Providence Portland Med. Ctr

Portland, Oregon, 97213, United States

Location

Oregon Health & Science University

Portland, Oregon, 97239, United States

Location

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

Location

Greenville Hospital System University Medical Center Institute For Translational Oncology Research

Greenville, South Carolina, 29605, United States

Location

Baylor Scott and White Research Institute

Dallas, Texas, 75246, United States

Location

Houston Methodist Research Institute

Houston, Texas, 77030, United States

Location

Riverside Regional Medical Center

Newport News, Virginia, 23601, United States

Location

Virginia Commonwealth University

Richmond, Virginia, 23229, United States

Location

Virginia Mason Medical Center

Seattle, Washington, 98101, United States

Location

West Virginia University Cancer Institute

Morgantown, West Virginia, 26506, United States

Location

Aurora Research Institute

Wauwatosa, Wisconsin, 53226, United States

Location

Landeskrankenhaus Universitatsklinikum Graz

Graz, 08036, Austria

Location

Innsbruck University Hospital

Innsbruck, A-6020, Austria

Location

Ordensklinikum Krankenhaus Der Barmherzigen Schwestern Linz

Linz, 04010, Austria

Location

Salzburger Universitatsklinikum

Salzburg, 05020, Austria

Location

Landeskrankenhaus Steyr

Steyr, 04400, Austria

Location

Allgemeines Krankenhaus Der Stadt Wien

Vienna, 01090, Austria

Location

Ulb Hospital Erasme

Brussels, 01070, Belgium

Location

Universitair Ziekenhuis Brussel

Brussels, 01090, Belgium

Location

Universitair Ziekenhuis Gent

Ghent, 09000, Belgium

Location

Hospital de Jolimont

Haine-st-paul, 07100, Belgium

Location

Az Groeninge Campus Kennedylaan

Kortrijk, 08500, Belgium

Location

Universitaire Ziekenhuis Leuven - Gasthuisberg

Leuven, 03000, Belgium

Location

Chu Ucl Namur University Hospital Mont-Godinne

Yvoir, 05530, Belgium

Location

Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada

Location

Cancercare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada

Location

Nova Scotia Health Authority/Qeii Health Sciences Centre

Halifax, Nova Scotia, B3H 4K4, Canada

Location

Princess Margaret Cancer Center

Toronto, Ontario, MG5 2M9, Canada

Location

McGill University Health Centre Research Institute

Montreal, Quebec, H4A 3J1, Canada

Location

Peking Union Medical College Hospital

Beijing, 100032, China

Location

West China Hospital Sichuan University

Chengdu, 610041, China

Location

Fujian Cancer Hospital

Fuzhou, 350005, China

Location

Sun Yat-Sen Memorial Hospital Sun Yat-Sen University

Guangdong, 510000, China

Location

Sun Yat-Sen Memorial Hospital Sun Yat-Sen University

Guangzhou, 510000, China

Location

Shulan Hangzhou Hospital Co Ltd

Hangzhou, 310000, China

Location

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, 310009, China

Location

Heilongjiang Province Cancer Hospital

Harbin, 150081, China

Location

University of Science and Technology of China-First Affiliated Hospital (Anhui Provincial Hospital)

Hefei, 230001, China

Location

Kunming 1St People'S Hospital

Kunming, 650032, China

Location

Jiangsu Province Hospital

Nanjing, 210029, China

Location

The Affiliated Hospital of Qingdao University

Shandong, 266071, China

Location

Zhongshan Hospital Fudan University

Shanghai, 200032, China

Location

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, 200092, China

Location

Xinhua Hospital

Shanghai, 200092, China

Location

Sichuan Cancer Hospital

Sichuan, 610041, China

Location

Tianjin Medical University Cancer Institute Hospital

Tianjin, 300060, China

Location

Tongji Hospital Huazhong University of Science and Technology

Wuhan, 430030, China

Location

Hubei Cancer Hospital

Wuhan, 430079, China

Location

Northern Jiangsu Peoples Hospital

Yangzhou, 225001, China

Location

Herlev Og Gentofte Hospital

Herlev, 02730, Denmark

Location

Docrates Cancer Center

Helsinki, 00180, Finland

Location

Helsinki University Central Hospital

Helsinki, 00290, Finland

Location

Tampere University Hospital

Tampere, 33521, Finland

Location

Institut Sainte Catherine

Avignon, 84918, France

Location

Chu Besancon Hospital Jean Minjoz

Besançon, 25030, France

Location

Institut Bergonie

Bordeaux, 33076, France

Location

Hopital Beaujon

Clichy, 92110, France

Location

Chu de Limoges - Hospital Dupuytren

Limoges, 87042, France

Location

Hopital Prive Jean Mermoz

Lyon, 69373, France

Location

Chu Hopital de La Timone

Marseille, 13385, France

Location

Centre Hospitalier Universitaire de Nantes

Nantes, 44000, France

Location

Centre Antoine Laccassagne

Nice, 06189, France

Location

Hospital Universitaire Pitie-Salpetriere

Paris, 75013, France

Location

Hopital Europeen Georges Pompidou (Hegp)

Paris, 75015, France

Location

Centre Hospitalier Universitaire de Bordeaux - Hospital Haut-Leveque

Pessac, 336600, France

Location

Hospital de La Miletrie

Poitiers, 86021, France

Location

Hopital Charles Nicolle Chu Rouen Hospital de Bois-Guillaume

Rouen, 76031, France

Location

University Hospital of Saint Etienne

Saint-Etienne, 42055, France

Location

Centre de Lutte Contre Le Cancer - Institut de Cancerologie de L'Ouest - Rene Gauducheau

Saint-Herblain, 44800, France

Location

Chu Toulouse Hopital Rangueil

Toulouse, 31059, France

Location

Chu Vandoeuvre-Les-Nancy Hopital Brabois

Vandœuvre-lès-Nancy, 54511, France

Location

Institut Gustave Roussy

Villejuif, 94805, France

Location

University Medical Center Rwth Aachen

Aachen, 52074, Germany

Location

Charite - Campus Virchow-Klinikum

Berlin, 13353, Germany

Location

Charite Universitaetsmedizin Berlin - Campus Charite Mitte

Berlin, 13353, Germany

Location

Universitatsklinikum Bonn Aoer

Bonn, 53127, Germany

Location

Klinikum Bremen-Nord

Bremen, 28755, Germany

Location

Universitatsklinikum Koln

Cologne, 50937, Germany

Location

University Clinic Carl Gustav Carus Technical University Dresden

Dresden, 01307, Germany

Location

Klinikum Der Johann Wolfgang Goethe University

Frankfurt am Main, 60590, Germany

Location

University Medical Center Freiburg

Freiburg im Breisgau, 79106, Germany

Location

Universitatsklinikum Hamburg Eppendorf

Hamburg, 20246, Germany

Location

Asklepios Klinik Altona

Hamburg, 22763, Germany

Location

Hannover Medical School

Hanover, 30625, Germany

Location

Universitaetsklinikum Des Saarlandes

Homburg / SAAR, 66421, Germany

Location

Universitatsklinikum Leipzig Aor

Leipzig, 04103, Germany

Location

Klinikum Ludwigsburg

Ludwigsburg, 71640, Germany

Location

Otto-Von-Guericke-Universitat Magdeburg

Magdeburg, 39120, Germany

Location

Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii

Mainz, 55131, Germany

Location

University Hospital Grosshadern Munich

Munich, 81377, Germany

Location

Klinikum Nuernberg

Nuremberg, 90419, Germany

Location

Universitaetsklinikum in Tubingen

Tübingen, 72076, Germany

Location

University Hospital Tuebingen

Tübingen, 72076, Germany

Location

Universitatkinikums Ulm

Ulm, 89081, Germany

Location

St. Vincent'S University Hospital

Dublin, D04 Y8V0, Ireland

Location

Soroka University Medical Center

Beersheba, 84001, Israel

Location

Rambam Health Care Campus

Haifa, 3109601, Israel

Location

Hadassah University Hospital

Jerusalem, 9112001, Israel

Location

Rabin Medical Center - Beilinson Hospital

Petah Tikva, 4941492, Israel

Location

Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel

Location

Azienda Ospedaliero Universitaria Delle Marche

Ancona, 60126, Italy

Location

Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari

Bari, 70124, Italy

Location

Ospedale Papa Giovanni Xxiii

Bergamo, 24127, Italy

Location

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi

Bologna, 40138, Italy

Location

Fondazione Del Piemonte Per L'Oncologia Ircc Candiolo

Candiolo, 10060, Italy

Location

Presidio Ospedaliero Garibaldi Nesima

Catania, 95100, Italy

Location

Ospedale Degli Infermi - Faenza

Faenza, 48018, Italy

Location

Irccs Azienda Ospedaliera Universitaria San Martino

Genova, 16132, Italy

Location

Istituto Di Ricovero E Cura A Carattere Scientifico (Irccs) Ospedale San Raffaele

Milan, 20132, Italy

Location

European Institute of Oncology

Milan, 20141, Italy

Location

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy

Location

Comitato Etico Fondazione Irccs Istituto Nazionale Dei Tumori Milano

Milan, 20133, Italy

Location

A.O.U. Di Modena - Policlinico

Modena, 41124, Italy

Location

Istituto Nazionale Tumori Irccs Fondazione Pascale

Napoli, 80131, Italy

Location

Universita Degli Studi Della Campania Luigi Vanvitelli U.O.C. Oncologia Medica

Napoli, 80138, Italy

Location

Azienda Ospedaliera Universitaria San Luigi Gonzaga Orbassano

Orbassano, 10043, Italy

Location

Iov - Istituto Oncologico Veneto Irccs

Padua, 35128, Italy

Location

Presidio Ospedaliero Pescara

Pescara, 65124, Italy

Location

Azienda Ospedaliera Universitaria Pisana

Pisa, 56126, Italy

Location

Fondazione Policlinico Universitario Agostino Gemelli Irccs

Roma, 00137, Italy

Location

Istituto Nazionale Tumori Regina Elena Irccs

Roma, 00144, Italy

Location

Universita Campus Bio Medico Di Roma

Rome, 00128, Italy

Location

Azienda Ospedaliera San Camillo Forlanini

Rome, 00152, Italy

Location

Irccs Istituto Clinico Humanitas

Rozzano, 20089, Italy

Location

Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria Alle Scotte

Siena, 53100, Italy

Location

Centro Ricerche Cliniche Di Verona (Crc)

Verona, 37134, Italy

Location

San Bartolo Hospital

Vicenza, 36100, Italy

Location

University of Tokyo Hospital

Bunkyō City, 113-8655, Japan

Location

Chiba University Hospital

Chiba, 260-8677, Japan

Location

Chiba Cancer Center

Chiba, 260-8717, Japan

Location

National Hospital Organization Kyushu Cancer Center

Fukuoka, 811-1395, Japan

Location

Kyushu University Hospital

Fukuoka, 812-8582, Japan

Location

Hiroshima University Hospital

Hiroshima, 734-8551, Japan

Location

Hyogo College of Medicine Hospital

Hyōgo, 663-8501, Japan

Location

Kanazawa University Hospital

Ishikawa, 920-8641, Japan

Location

Teikyo University Hospital

Itabashi-ku, 173-8606, Japan

Location

Kobe University Hospital

Kobe, 650-0017, Japan

Location

Cancer Institute Hospital of Jfcr

Kōtoku, 135-8550, Japan

Location

Kyoto University Hospital

Kyoto, 606-8507, Japan

Location

Nho Shikoku Cancer Center

Matsuyama, 791-0280, Japan

Location

Kyorin University Hospital

Mitaka-shi, 181-8611, Japan

Location

Aichi Cancer Center Hospital

Nagoya, 464-8681, Japan

Location

Niigata Cancer Center Hospital

Niigata, 951-8566, Japan

Location

Osaka International Cancer Institute

Osaka, 541-8567, Japan

Location

Saitama Cancer Center

Saitama, 362-0806, Japan

Location

Hokkaido University Hospital

Sapporo, 060-8648, Japan

Location

Kindai University Hospital

Sayama, 589-8511, Japan

Location

Tohoku University Hospital

Sendai, 980-8574, Japan

Location

Jichi Medical University Hospital

Shimotsuke-shi, 329-0498, Japan

Location

Keio University Hospital

Shinjuku-ku, 160-8582, Japan

Location

Shizuoka Cancer Center

Shizuoka, 411-8777, Japan

Location

Osaka University Hospital

Suita-shi, 565-0871, Japan

Location

Toyama University Hospital

Toyama, 930-0194, Japan

Location

Yamaguchi University Hospital

Ube, 755-8505, Japan

Location

Wakayama Medical University Hospital

Wakayama, 641-8509, Japan

Location

Yokohama City University Medical Center

Yokohama, 232-0024, Japan

Location

Kanagawa Cancer Center

Yokohama, 241-8515, Japan

Location

Oita University Hospital

Yufu-shi, 879-5593, Japan

Location

Amsterdam University Medical Centre

Amsterdam, 1100 DD, Netherlands

Location

Maastricht Umc+

Maastricht, 6202 AZ, Netherlands

Location

Erasmus Medical Center

Rotterdam, 3015 CE, Netherlands

Location

Umc Utrecht

Utrecht, 3584 CX, Netherlands

Location

Oslo University Hospital

Oslo, 00450, Norway

Location

Hospital Materno Teresa Herrera

A Coruña, 15006, Spain

Location

Hospital de La Santa Creu I Sant Pau

Barcelona, 08026, Spain

Location

Hospital General Universitario Vall D Hebron

Barcelona, 08035, Spain

Location

Hospital Clinic Barcelona Main

Barcelona, 08036, Spain

Location

Hospital Universitario Reina Sofia

Córdoba, 14004, Spain

Location

HOSPITAL UNiVERSITARIO DONOSTIA

Donostia / San Sebastian, 20014, Spain

Location

Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain

Location

Hospital Universitario Ramon Y Cajal

Madrid, 28034, Spain

Location

Hospital Universitario Hm Sanchinarro

Madrid, 28050, Spain

Location

Hospital Regional Universitario de Malaga

Málaga, 29010, Spain

Location

Clinica Universidad de Navarra (Cun)

Pamplona, 31008, Spain

Location

Hospital Universitari Parc Tauli

Sabadell, 08208, Spain

Location

Hospital Universitario Marques de Valdecilla

Santander, 39008, Spain

Location

Hospital General Universitario de Valencia

Valencia, 46014, Spain

Location

Karolinska Institute Universitetssjukhuset Solna

Solna, 171 64, Sweden

Location

Inselspital - Universitaetsspital Bern

Bern, 03010, Switzerland

Location

Universitatsspital Zurich

Zurich, 08091, Switzerland

Location

Aberdeen Royal Infirmary

Aberdeen, AB25 2ZN, United Kingdom

Location

Addenbrookes Hospital

Cambridge, CB2 0QQ, United Kingdom

Location

Velindre Cancer Centre

Cardiff, CF14 2TL, United Kingdom

Location

University Hospital Coventry and Warwickshire

Coventry, CV2 2DX, United Kingdom

Location

The Royal Marsden Nhs Foundation Trust - Chelsea

London, SW3 6JJ, United Kingdom

Location

Imperial College Healthcare Nhs Trust - Hammersmith Hospital

London, W12 0HS, United Kingdom

Location

University College London Hospitals (Uclh)

London, WC1E 6BT, United Kingdom

Location

Kent Oncology Centre - Maidstone Hospital

Maidstone, ME16 9QQ, United Kingdom

Location

The Christie Nhs Foundation Trust

Manchester, M20 4BV, United Kingdom

Location

The Royal Marsden Nhs Foundation Trust - Sutton

Sutton, SM2 5PT, United Kingdom

Location

Related Publications (1)

  • Bekaii-Saab TS, Valle JW, Van Cutsem E, Rimassa L, Furuse J, Ioka T, Melisi D, Macarulla T, Bridgewater J, Wasan H, Borad MJ, Abou-Alfa GK, Jiang P, Lihou CF, Zhen H, Asatiani E, Feliz L, Vogel A. FIGHT-302: first-line pemigatinib vs gemcitabine plus cisplatin for advanced cholangiocarcinoma with FGFR2 rearrangements. Future Oncol. 2020 Oct;16(30):2385-2399. doi: 10.2217/fon-2020-0429. Epub 2020 Jul 17.

MeSH Terms

Conditions

Cholangiocarcinoma

Interventions

pemigatinibGemcitabineCisplatin

Condition Hierarchy (Ancestors)

AdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasms

Intervention Hierarchy (Ancestors)

Heterocyclic CompoundsDeoxycytidineCytidinePyrimidine NucleosidesPyrimidinesHeterocyclic Compounds, 1-RingChlorine CompoundsInorganic ChemicalsNitrogen CompoundsPlatinum Compounds

Study Officials

  • Peter Langmuir, MD

    Incyte Corporation

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR
Expanded Access
Yes

Study Record Dates

First Submitted

August 29, 2018

First Posted

September 4, 2018

Study Start

June 3, 2019

Primary Completion

July 7, 2025

Study Completion

July 7, 2025

Last Updated

August 24, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

Incyte shares data with qualified external researchers after a research proposal is submitted. These requests are reviewed and approved by a review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations. The trial data availability is according to the criteria and process described on https://www.incyte.com/our-company/compliance-and-transparency

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Data will be shared after the primary publication or 2 years after the study has ended for market authorized products and indications.
Access Criteria
Data from eligible studies will be shared with qualified researchers according to the criteria and process described in the Data Sharing section of the www.incyteclinicaltrials.com website. For approved requests, the researchers will be granted access to anonymized data under the terms of a data sharing agreement.
More information

Locations