Alternate Day Fasting and Exercise in Overweight or Obese Adults
Effects of Alternate Day Fasting and Exercise on Body Weight, Visceral Fat, and Metabolic Parameters in Overweight or Obese Adults: A Randomized Controlled Trial
1 other identifier
interventional
100
0 countries
N/A
Brief Summary
Alternate day fasting is known to be helpful to control weight and have a positive effect on insulin resistance and cardiovascular risk factors. However, there have been no studies on weight reduction program combining alternate day fasting with exercise which preserves lean mass in Korea. The purpose of this randomized clinical trial is to examine the effects of alternate day fasting and exercise on weight reduction, visceral fat, and metabolic parameters in overweight or obese adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Apr 2014
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 10, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 8, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
March 8, 2016
CompletedFirst Submitted
Initial submission to the registry
August 28, 2018
CompletedFirst Posted
Study publicly available on registry
August 29, 2018
CompletedAugust 29, 2018
August 1, 2018
1.9 years
August 28, 2018
August 28, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
Change in body weight
body weight (kg)
baseline, 8 weeks
Secondary Outcomes (6)
Change in visceral fat
baseline, 8 weeks
Change in fasting glucose
baseline, 8 weeks
Change in insulin
baseline, 8 weeks
Change in triglyceride
baseline, 8 weeks
Change in high-density lipoprotein cholesterol (HDL-cholesterol)
baseline, 8 weeks
- +1 more secondary outcomes
Study Arms (4)
Alternate Day Fasting and Exercise
EXPERIMENTALAlternate Day Fasting
EXPERIMENTALExercise
EXPERIMENTALControl
NO INTERVENTIONregular eating and exercise habits for 8 weeks
Interventions
During the 8-week intervention, participants consumed 25% of their daily recommended energy intake (approximately 500 kcal) on each "fast day" (24 h), and consumed food ad libitum on each "feed day" (24 h). The "fast day" and "feed day" were repeated every other day, and the "fast day" occurred 3 days per week.
During the 8-week intervention, participants visited the research center gym at least three times per week and received exercise logs. Each exercise session began with 5 minutes of warm-up and ended with 5 minutes of cool-down. Resistance training was performed using weight training machines, barbells, and dumbbells for 40 minutes. Aerobic exercise was performed on motorized treadmills for 20 minutes.
Eligibility Criteria
You may qualify if:
- Age 20-65 years
- Body mass index (BMI) more than 23.0 kg/m² (overweight or obese for Asian populations, according to the World Health Organization)
You may not qualify if:
- Participants with weight gain more than 5kg in the last 3 months
- Participants with history of bariatric surgery
- Participants with secondary obesity, such as hypothyroidism
- Participants with uncontrolled hypertension or type 1 diabetes
- Participants who are taking anti-diabetic medications due to type 2 diabetes
- Participants with hepatic disease (AST or ALT ≥200 mg/dL)
- Participants with renal disease (serum creatinine ≥2.0 mg/dL)
- Participants with pancreatitis or related disorders
- Participants with acute infectious diseases (i.e., pneumonia, acute enteritis, or urinary infection)
- Participants with chronic inflammatory diseases (i.e., rheumatoid arthritis, or lupus)
- Participants with overeating behavior
- Participants with history of cardiovascular diseases
- Participants with history of cancer
- Participants who are taking anti-obesity, anti-diabetic, diuretic, central-nervous system, antidepressant, antipsychotic, or steroid medications
- Pregnant or lactating women
- +4 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Allaf M, Elghazaly H, Mohamed OG, Fareen MFK, Zaman S, Salmasi AM, Tsilidis K, Dehghan A. Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2021 Jan 29;1(1):CD013496. doi: 10.1002/14651858.CD013496.pub2.
PMID: 33512717DERIVEDOh M, Kim S, An KY, Min J, Yang HI, Lee J, Lee MK, Kim DI, Lee HS, Lee JW, Jeon JY. Effects of alternate day calorie restriction and exercise on cardio-metabolic risk factors in overweight and obese adults: an exploratory randomized controlled study. BMC Public Health. 2018 Sep 15;18(1):1124. doi: 10.1186/s12889-018-6009-1.
PMID: 30219052DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
August 28, 2018
First Posted
August 29, 2018
Study Start
April 10, 2014
Primary Completion
March 8, 2016
Study Completion
March 8, 2016
Last Updated
August 29, 2018
Record last verified: 2018-08