Translation and Clinical Implementation of a Test of Language and Short-term Memory in Aphasia

NCT03635554 | Enrolling By Invitation

• 1 other identifier: TempleU2
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This project aims to develop a clinically feasible version of a laboratory-developed assessment battery for language and verbal short-term memory difficulties in aphasia.

Conditions

Aphasia

Keywords

Aphasia

Outcome Measures

Primary Outcomes (1)

• Proportions correct on subtests of the Test of Language and Short-term Memory in Aphasia (TALSA)

  Participants will be administered 15-20 subtests of the TALSA that assess aspects of language (phoneme discrimination, sentence comprehension) and short-term memory (e.g., repetition span) abilities. Their responses on these measures will be evaluated in a item response analysis to determine which items are ideal to use in a smaller version of this test that is feasible to use in clinical practice. Another group of people with aphasia will be administered the clinical version (when it is complete) to develop normative data for that assessment battery.

  two to three years December 1, 2017 through December 15, 2017 through November 30, 2022.

Eligibility Criteria

• Age: 21 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants with aphasia will have single or multiple left hemisphere lesions, but no right hemisphere lesions. They can be between the ages of 21 and 80. Their aphasia can range in severity from mild to severe and can be of any type except global aphasia. Their language output can be fluent or nonfluent and their comprehension can be mild moderately impaired.

You may qualify if:

• single or multiple left hemisphere lesions
• at least one year post-stroke.
• high-school educated
• negative histories for mental illness and alcohol/substance abuse.
• passed an audiometric pure-tone, air conduction screening at 25 dB HL at 1K, 2K and 4K Hz for at least one ear.

You may not qualify if:

• English as a second language Right hemisphere stroke Less than 6 months post-onset of stroke.

Sponsors & Collaborators

• Temple University: lead
• University of Washington: collaborator

Study Sites (1)

Temple University

Philadelphia, Pennsylvania, 19122, United States

Location

MeSH Terms

Conditions

Aphasia

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Nadine Martin, Ph.D.

  Temple University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Communication Sciences and Disorders

Study Record Dates

• First Submitted: August 15, 2018
• First Posted: August 17, 2018
• Study Start: December 15, 2017
• Primary Completion: November 30, 2025
• Study Completion: November 30, 2025
• Last Updated: April 10, 2024

Record last verified: 2024-04

Locations

US (1)